scholarly journals Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease

Brain ◽  
2004 ◽  
Vol 127 (6) ◽  
pp. 1219-1228 ◽  
Author(s):  
M. Peschanski
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Strategy ◽  
Neural Transplants

scholarly journals Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

2009 ◽  
Vol 106 (30) ◽  
pp. 12483-12488 ◽  
Author(s):  
F. Cicchetti ◽  
S. Saporta ◽  
R. A. Hauser ◽  
M. Parent ◽  
M. Saint-Pierre ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuronal Degeneration ◽  
Neural Transplants

scholarly journals A patient with Huntington’s disease and long-surviving fetal neural transplants that developed mass lesions

2008 ◽  
Vol 117 (3) ◽  
pp. 329-338 ◽  
Author(s):  
C. Dirk Keene ◽  
Rubens C. Chang ◽  
James B. Leverenz ◽  
Oleg Kopyov ◽  
Susan Perlman ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neural Transplants ◽  
Mass Lesions

P1.016 Neural transplants in patients with Huntington's disease undergo disease-speciflc neuronal degeneration

2009 ◽  
Vol 15 ◽  
pp. S33
Author(s):  
F. Cicchetti ◽  
S. Saporta ◽  
R. Hauser ◽  
M. Parent ◽  
M. Saint-Pierre ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuronal Degeneration ◽  
Neural Transplants

Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease

2012 ◽  
Vol 63 (4) ◽  
pp. 719-732 ◽  
Author(s):  
Li-Wen Chen ◽  
Lin-Yea Horng ◽  
Chia-Ling Wu ◽  
Hui-Ching Sung ◽  
Rong-Tsun Wu
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Strategy

scholarly journals Olfactory Dysfunction in Huntington’s Disease

2021 ◽  
pp. 1-10
Author(s):  
Jorge Patino ◽  
Nicholas E. Karagas ◽  
Shivika Chandra ◽  
Nivedita Thakur ◽  
Erin Furr Stimming
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Strategy ◽  
Specific Treatment ◽  
Olfactory Dysfunction ◽  
Cross Cultural ◽  
Common Symptom ◽  
Progressive Decline ◽  
Advanced Stages ◽  
Olfactory Impairment

Olfactory dysfunction is a common symptom in patients with neurodegenerative disorders, including Huntington’s disease (HD). Understanding its pathophysiology is important in establishing a preventive and therapeutic plan. In this literature review, we cover the physiology of olfaction, its role in neurodegeneration, and its characteristics in patients with HD. In the general population, olfactory dysfunction is present in 3.8–5.8%and the prevalence increases significantly in those older than 80 years. For HD, data regarding prevalence rates are lacking and the scales used have been inconsistent or have been restructured due to concerns about cross-cultural understanding. Pathogenic huntingtin deposits have been found in the olfactory bulb of individuals with HD, although no studies have correlated this with the grade of olfactory impairment. Olfactory dysfunction is present in both premanifest and manifest patients with HD, showing a progressive decline over time with more severe deficits at advanced stages. No specific treatment for olfactory impairment in HD has been proposed; identifying and avoiding potential medications that cause olfactory dysfunction, as well as general safety recommendations remain the basis of the therapeutic strategy.

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