scholarly journals Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

2014 ◽  
Vol 124 (10) ◽  
pp. 4411-4428 ◽  
Author(s):  
Verónica Brito ◽  
Albert Giralt ◽  
Lilian Enriquez-Barreto ◽  
Mar Puigdellívol ◽  
Nuria Suelves ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophin Receptor ◽  
Memory Dysfunction

scholarly journals Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Peng Liu ◽  
Yinjie Li ◽  
Wei Yang ◽  
Danyang Liu ◽  
Xuefei Ji ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Coordination ◽  
Memory Function ◽  
Transgenic Animal ◽  
Tolfenamic Acid ◽  
Mutant Huntingtin ◽  
Memory Dysfunction ◽  
Object Recognition Test ◽  
Model Of Alzheimer’S Disease

Tolfenamic acid is a nonsteroidal anti-inflammatory drug with neuroprotective properties, and it alleviates learning and memory deficits in the APP transgenic mouse model of Alzheimer’s disease. However, whether tolfenamic acid can prevent motor and memory dysfunction in transgenic animal models of Huntington’s disease (HD) remains unclear. To this end, tolfenamic acid was orally administered to transgenic R6/1 mice from 10 to 20 weeks of age, followed by several behavioral tests to evaluate motor and memory function. Tolfenamic acid improved motor coordination in R6/1 mice as tested by rotarod, grip strength, and locomotor behavior tests and attenuated memory dysfunction as analyzed using the novel object recognition test and passive avoidance test. Tolfenamic acid decreased the expression of mutant huntingtin in the striatum of 20-week-old R6/1 mice by inhibiting specificity protein 1 expression and enhancing autophagic function. Furthermore, tolfenamic acid exhibited antioxidant effects in both R6/1 mice and PC12 cell models. Collectively, these results suggest that tolfenamic acid has a good therapeutic effect on R6/1 mice, and may be a potentially useful agent in the treatment of HD.

Voxel-based morphometry at the single subject level: a pilot study in early Huntington's disease

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
M Mühlau ◽  
A Wohlschläger ◽  
C Gaser ◽  
M Valet ◽  
S Nunnemann ◽  
...  
Keyword(s):  
Pilot Study ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Single Subject ◽  
Voxel Based Morphometry
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