scholarly journals Iron oxide/PLGA nanoparticles for magnetically controlled drug release

2017 ◽  
Vol 53 ◽  
pp. S53-S60 ◽  
Author(s):  
M. Rosaria Ruggiero ◽  
Simonetta Geninatti Crich ◽  
Elisabetta Sieni ◽  
Paolo Sgarbossa ◽  
E. Cavallari ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Plga Nanoparticles

scholarly journals Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin

2017 ◽  
Vol 38 (6) ◽  
pp. 943-953 ◽  
Author(s):  
Yan-na Cui ◽  
Qing-xing Xu ◽  
Pooya Davoodi ◽  
De-ping Wang ◽  
Chi-Hwa Wang
Keyword(s):  
Drug Release ◽  
Intracellular Delivery ◽  
Controlled Drug Release ◽  
Plga Nanoparticles

scholarly journals Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity

2018 ◽  
Author(s):  
S. Pieper ◽  
H. Onafuye ◽  
D. Mulac ◽  
Jindrich Cinatl ◽  
Mark N. Wass ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Neuroblastoma Cells ◽  
Controlled Drug Release ◽  
Plga Nanoparticles ◽  
Cellular Level ◽  
Drug Load ◽  
Anti Cancer ◽  
Solvent Displacement ◽  
Cancer Activity

AbstractNanoparticles are under investigation as carrier systems for anti-cancer drugs. They have been shown to accumulate in cancer tissues through the enhanced permeability and retention (EPR) effect, to reduce toxicity to non-target tissues, and to protect drugs from preliminary inactivation. However, nanoparticle preparations are not commonly compared for their anti-cancer effects at the cellular level. Here, we prepared doxorubicin-loaded nanoparticles based on poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) by solvent displacement and emulsion diffusion approaches. The resulting nanoparticles covered a size range between 73 and 246 nm. PLGA-PEG nanoparticle preparation by solvent displacement resulted in the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH7 reaching 53 µg doxorubicin/mg nanoparticle. In addition, these PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst-like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH7 (presumably due to their high drug load and superior drug release kinetics) exerted the strongest anti-cancer effects. In conclusion, doxorubicin-loaded nanoparticles made by different methods from different materials displayed substantial discrepancies in their anti-cancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anti-cancer efficacy. The design of drug-loaded nanoparticles with optimised anti-cancer activity at the cellular level is an important step in the development of improved nanoparticle preparations for anti-cancer therapy.

Iron oxide-loaded hollow mesoporous silica nanocapsules for controlled drug release and hyperthermia

2013 ◽  
Vol 49 (97) ◽  
pp. 11436 ◽  
Author(s):  
Feng Lu ◽  
Adriana Popa ◽  
Shiwei Zhou ◽  
Jun-Jie Zhu ◽  
Anna Cristina S. Samia
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Controlled Drug Release ◽  
Hollow Mesoporous Silica ◽  
Silica Nanocapsules
Sign in / Sign up

Export Citation Format

Share Document