scholarly journals Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin

2017 ◽  
Vol 38 (6) ◽  
pp. 943-953 ◽  
Author(s):  
Yan-na Cui ◽  
Qing-xing Xu ◽  
Pooya Davoodi ◽  
De-ping Wang ◽  
Chi-Hwa Wang
Keyword(s):  
Drug Release ◽  
Intracellular Delivery ◽  
Controlled Drug Release ◽  
Plga Nanoparticles

scholarly journals Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity

2018 ◽  
Author(s):  
S. Pieper ◽  
H. Onafuye ◽  
D. Mulac ◽  
Jindrich Cinatl ◽  
Mark N. Wass ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Neuroblastoma Cells ◽  
Controlled Drug Release ◽  
Plga Nanoparticles ◽  
Cellular Level ◽  
Drug Load ◽  
Anti Cancer ◽  
Solvent Displacement ◽  
Cancer Activity

AbstractNanoparticles are under investigation as carrier systems for anti-cancer drugs. They have been shown to accumulate in cancer tissues through the enhanced permeability and retention (EPR) effect, to reduce toxicity to non-target tissues, and to protect drugs from preliminary inactivation. However, nanoparticle preparations are not commonly compared for their anti-cancer effects at the cellular level. Here, we prepared doxorubicin-loaded nanoparticles based on poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) by solvent displacement and emulsion diffusion approaches. The resulting nanoparticles covered a size range between 73 and 246 nm. PLGA-PEG nanoparticle preparation by solvent displacement resulted in the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH7 reaching 53 µg doxorubicin/mg nanoparticle. In addition, these PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst-like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH7 (presumably due to their high drug load and superior drug release kinetics) exerted the strongest anti-cancer effects. In conclusion, doxorubicin-loaded nanoparticles made by different methods from different materials displayed substantial discrepancies in their anti-cancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anti-cancer efficacy. The design of drug-loaded nanoparticles with optimised anti-cancer activity at the cellular level is an important step in the development of improved nanoparticle preparations for anti-cancer therapy.

scholarly journals Iron oxide/PLGA nanoparticles for magnetically controlled drug release

2017 ◽  
Vol 53 ◽  
pp. S53-S60 ◽  
Author(s):  
M. Rosaria Ruggiero ◽  
Simonetta Geninatti Crich ◽  
Elisabetta Sieni ◽  
Paolo Sgarbossa ◽  
E. Cavallari ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Plga Nanoparticles

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

scholarly journals Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Joseph C. Bear ◽  
P. Stephen Patrick ◽  
Alfred Casson ◽  
Paul Southern ◽  
Fang-Yu Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Gi Tract

Improvement of Medication Adherence and Controlled Drug Release by Optimized Acetaminophen Formulation

2021 ◽  
Author(s):  
Suyoung Been ◽  
Jeongmin Choi ◽  
Young Hun Lee ◽  
Pil Yun Kim ◽  
Won Kyung Kim ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Drug Release ◽  
Controlled Drug Release
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