Synthesis and characterisation of super-paramagnetic iron oxide nanoparticles (SPIONs) for minimising Aeromonas hydrophila load from freshwater

Background: The current study was conducted to prepare an efficient super-paramagnetic iron oxide nanoparticle (SPIONs) to remove Aeromonas hydrophila from water. Methods: The nanoparticles were synthesized by the co-precipitation method and characterized by DLS, UV-Vis spectrophotometer, FT-IR, XRD, FEG-TEM, and VSM analysis. Results and Discussion: The results showed that the synthesized SPIONs were having a size range of 8-12nm with magnetic property. Bacteria removal efficiency and antibacterial activity of SPIONs were assessed in sterile distilled water by adding different concentrations of SPIONs viz. 0, 6.25, 12.5, 25, 50, 100, 200, 500, and 1000µM with different initial bacterial loads viz. 1×103, 1×104, 1×105, 1×106, and 1×107 CFU mL−1 at different time intervals 15, 30, 45, and 60 min. At low bacterial load (1×103 to 1×105 CFU mL−1), 95 to 99.99% of bacteria were removed by low SPIONs concentration (6.25-100µM) by 15min which was increased up to 100% by 30min. However, at high bacterial load (1×106 to 1×107 CFU mL−1), more than 87 to 95% of bacteria were removed by the highest SPIONs concentration (1000µM) by 15min, which was increased above 93 to 99.99% by increasing the exposure time to 60min. At low bacterial load (1×103 to1×105 CFU mL−1), the effective concentration was 3.21 to 6.42µM at 15-60 min intervals. Meanwhile, the effective concentration at high bacterial load was 267.81 µM at 15min, which was decreased to 104.09 µM with increasing exposure time to 60min. Conclusion: Based on the results, it is concluded that the antibacterial effect against A. hydrophila depends on the concentration as well as the exposure time of SPIONs. A low concentration of SPIONs is sufficient to remove 100% of bacterial load in lower exposure time and increasing concentration of SPIONs increases the antibacterial effect. However, further research requires to find the safe concentration of SPIONs for using it as a novel antibacterial agent for the treatment of aeromonads disease in aquaculture.

Long-term in vivo performances of polylactide / iron oxide nanoparticles core-shell fibrous nanocomposites as MRI-visible magneto-scaffolds

There is a growing interest in magnetic nanocomposites in biomaterials science. In particular, nanocomposites that combine poly(lactide) (PLA) nanofibers and super paramagnetic iron oxide nanoparticles (SPIONs), which can be obtained...

Withdrawal Notice: The Recent Advancement in the Field of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) for Aiming Breast Cancer

The article has been withdrawn at the request of the authors and editor of the journal Current Drug Metabolism. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

A Novel Approach for Non-Invasive Lung Imaging and Targeting Lung Immune Cells

Despite developments in pulmonary radiotherapy, radiation-induced lung toxicity remains a problem. More sensitive lung imaging able to increase the accuracy of diagnosis and radiotherapy may help reduce this problem. Super-paramagnetic iron oxide nanoparticles are used in imaging, but without further modification can cause unwanted toxicity and inflammation. Complex carbohydrate and polymer-based coatings have been used, but simpler compounds may provide additional benefits. Herein, we designed and generated super-paramagnetic iron oxide nanoparticles coated with the neutral natural dietary amino acid glycine (GSPIONs), to support non-invasive lung imaging and determined particle biodistribution, as well as understanding the impact of the interaction of these nanoparticles with lung immune cells. These GSPIONs were characterized to be crystalline, colloidally stable, with a size of 12 ± 5 nm and a hydrodynamic diameter of 84.19 ± 18 nm. Carbon, Hydrogen, Nitrogen (CHN) elemental analysis estimated approximately 20.2 × 103 glycine molecules present per nanoparticle. We demonstrated that it is possible to determine the biodistribution of the GSPIONs in the lung using three-dimensional (3D) ultra-short echo time magnetic resonance imaging. The GSPIONs were found to be taken up selectively by alveolar macrophages and neutrophils in the lung. In addition, the GSPIONs did not cause changes to airway resistance or induce inflammatory cytokines. Alveolar macrophages and neutrophils are critical regulators of pulmonary inflammatory diseases, including allergies, infections, asthma and chronic obstructive pulmonary disease (COPD). Therefore, pulmonary Magnetic Resonance (MR) imaging and preferential targeting of these lung resident cells by our nanoparticles offer precise imaging tools, which can be utilized to develop precision targeted radiotherapy as well as diagnostic tools for lung cancer, thereby having the potential to reduce the pulmonary complications of radiation.