Effects of Photobiomodulation on Changes in Cognitive Function and Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment: A Pilot Uncontrolled Trial

2021 ◽  
pp. 1-7
Author(s):  
Ji Soo Baik ◽  
Tae Young Lee ◽  
Nam Gyun Kim ◽  
Kyoungjune Pak ◽  
Sung-Hwa Ko ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Cognitive Function ◽  
Regional Cerebral Blood Flow ◽  
Photon Emission ◽  
Anterior Cingulate ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood ◽  
The Brain

Background: Photobiomodulation (PBM) affects local blood flow regulation through nitric oxide generation, and various studies have reported on its effect on improving cognitive function in neurodegenerative diseases. However, the effect of PBM in the areas of the vertebral arteries (VA) and internal carotid arteries (ICA), which are the major blood-supplying arteries to the brain, has not been previously investigated. Objective: We aimed to determine whether irradiating PBM in the areas of the VA and ICA, which are the major blood-supplying arteries to the brain, improved regional cerebral blood flow (rCBF) and cognitive function. Methods: Fourteen patients with mild cognitive impairments were treated with PBM. Cognitive assessment and single-photon emission computed tomography were implemented at the baseline and at the end of PBM. Results: Regarding rCBF, statistically significant trends were found in the medial prefrontal cortex, lateral prefrontal cortex, anterior cingulate cortex, and occipital lateral cortex. Based on the cognitive assessments, statistically significant trends were found in overall cognitive function, memory, and frontal/executive function. Conclusion: We confirmed the possibility that PBM treatment in the VA and ICA areas could positively affect cognitive function by increasing rCBF. A study with a larger sample size is needed to validate the potential of PBM.

scholarly journals Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Teruyuki Matsuoka ◽  
Jin Narumoto ◽  
Keisuke Shibata ◽  
Aiko Okamura ◽  
Shogo Taniguchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Regional Cerebral Blood Flow ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood

The aim of this study was to examine the effect of toki-shakuyaku-san (TSS) on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single-photon emission computed tomography (SPECT). All subjects were administered TSS (7.5 g/day) for eight weeks. SPECT and evaluations using the Mini Mental State Examination (MMSE), Neuropsychiatric Inventory, and Physical Self-Maintenance Scale were performed before and after treatment with TSS. Three patients with MCI and five patients with AD completed the study. No adverse events occurred during the study period. After treatment with TSS, regional cerebral blood flow (rCBF) in the posterior cingulate was significantly higher than that before treatment. No brain region showed a significant decrease in rCBF. TSS treatment also tended to improve the score for orientation to place on the MMSE. These results suggest that TSS could be useful for treatment of MCI and AD.

scholarly journals Brain Correlates of Memory Processes in Patients with Dementia of Alzheimer's Type: A Spect Activation Study

1998 ◽  
Vol 18 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Dominique Cardebat ◽  
Jean-François Démonet ◽  
Michèle Puel ◽  
Alain Agniel ◽  
Gerard Viallard ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Memory Task ◽  
Frontal Region ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood ◽  
Actual Performance

Task-induced changes in regional cerebral blood flow (rCBF) during verbal episodic memory activation were compared in 17 right-handed patients with dementia of the Alzheimer's type (DAT) and 20 healthy volunteers. Regional cerebral blood flow was assessed using single photon emission computed tomography (SPECT) and an injection of 133Xe (xenon, isotope of mass 133) in 21 regions of interest (ROI) during rest, passive listening to 36 words, and memorizing of a 12-word list repeated three times. In healthy subjects, memory—listening comparison showed activation of a distributed system involving several left-sided ROI, especially the posterior inferior frontal region. In patients with DAT, the same pattern of activation was found for listening—rest comparison, and no significant changes were found in memory—listening comparison. During listening compared with rest, significant activation was observed in left-sided hypoperfused regions. A significant correlation between memory performance and rCBF recorded in patients with DAT during the memory task was found only in the right lateral frontal region, a region that was not hypoperfused significantly in patients. The involvement of this region might relate to either retrieval effort or actual performance of patients with DAT on the memory task.

Evaluation of Regional Cerebral Blood Flow in Alzheimer's Disease Patients with Subclinical Hypothyroidism

2015 ◽  
Vol 39 (5-6) ◽  
pp. 360-367 ◽  
Author(s):  
Megumi Haji ◽  
Noriyuki Kimura ◽  
Takuya Hanaoka ◽  
Yasuhiro Aso ◽  
Makoto Takemaru ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subclinical Hypothyroidism ◽  
Regional Cerebral Blood Flow ◽  
Photon Emission ◽  
Statistical Parametric Mapping ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood

Background: This study examined regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients with and without subclinical hypothyroidism (SCH). Methods: Eleven AD patients with SCH and 141 AD patients without SCH underwent brain perfusion single photon emission computed tomography (SPECT). The SPECT data were analyzed by statistical parametric mapping (SPM8) and FineSRT. Results: AD patients with SCH showed a significantly decreased rCBF mainly in the temporal lobe and thalamus, whereas those without SCH showed a significantly decreased rCBF in the parietotemporal lobe and cingulate gyrus as well as the frontal lobe. Conclusion: Our findings suggest that SCH may affect cerebral perfusion in regions associated with the memory function.

scholarly journals Changes in regional cerebral blood flow due to cognitive activation among patients with schizophrenia

2000 ◽  
Vol 177 (3) ◽  
pp. 222-228 ◽  
Author(s):  
B. K. Toone ◽  
C. I. Okocha ◽  
K. Sivakumar ◽  
G. M. Syed
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Anterior Cingulate ◽  
Control Group ◽  
Wisconsin Card Sort Test ◽  
Card Sorting ◽  
Regional Cerebral Blood

BackgroundThe regional cerebral blood flow (rCBF) response to the Wisconsin Card Sort Test (WCST) has been used to assess the functional integrity of the prefrontal cortex in patients with schizophrenia.AimsIn this study, patients were divided into two groups according to whether they had made few or many perseverative errors on a modified version of the WCST. A control group consisted of normal volunteers. The groups were then compared with respect to rCBF response to WCST activation.MethodrCBF was measured during administration of a modified version of the WCST and during a card sorting control task, using single photon emission computerised tomography (SPECT).ResultsPerformance of the modified WCST was associated with a widespread and substantial increase in rCBF, particularly in the frontal region. The poorly performing group of patients with schizophrenia showed only a modest increase in rCBF in the left anterior cingulate region.ConclusionSubjects with schizophrenia are able to respond to specific neuropsychological challenge with activation of the frontal regions.

Improvement in Regional Cerebral Blood Flow and Cerebral Vasoreactivity after Extracranial-Intracranial Arterial Bypass

Neurosurgery ◽  
1988 ◽  
Vol 22 (5) ◽  
pp. 913-919 ◽  
Author(s):  
Hunt H. Batjer ◽  
Michael D. Devous ◽  
Phillip D. Purdy ◽  
Bruce Mickey ◽  
Frederick J. Bonte ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood ◽  
Flow Measurements ◽  
Cerebrovascular Reserve ◽  
Neurological Improvement

Abstract Regional cerebral blood flow was measured with xenon-133 inhalation single photon emission computed tomography in a patient who developed a neurological deficit after carotid ligation. Hemispheric hypoperfusion was noted in resting studies and impaired vasoreactivity was suggested by lack of symmetrical flow augmentation after acetazolamide administration. Because of progressive neurological deterioration, an extracranial-intracranial bypass was performed. After prompt neurological improvement, repeat cerebral blood flow measurements at 1 and 9 weeks postoperatively confirmed improvement in resting flow and vasoreactivity. It is possible that decreased cerebrovascular reserve implied by measurements of vasoreactivity can identify patients who will benefit from surgical revascularization.

scholarly journals Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jooyeon J. Im ◽  
Hyeonseok Jeong ◽  
Young Do Kim ◽  
Kyung-Sool Jang ◽  
In-Uk Song ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Photon Emission ◽  
Case Series ◽  
Emission Computed Tomography ◽  
Healthy Controls ◽  
Regional Cerebral Blood ◽  
Clinical Dementia Rating ◽  
Posterior Cingulate

Objective: Clinical and radiological findings on neurosyphilis are fairly non-specific and there is a paucity of functional neuroimaging studies on neurosyphilis other than case reports and case series. The purpose of this study was to investigate brain perfusion abnormalities in patients with neurosyphilis.Methods: Four HIV-negative neurosyphilis patients and 4 healthy controls underwent clinical evaluation, brain technetium-99m ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed tomography (SPECT) imaging, and neuropsychological assessments which included the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating—Sum of Boxes (CDR-SOB), and Global Deterioration Scale (GDS). Voxel-wise differences in regional cerebral blood flow were compared between the two groups.Results: Neuropsychological test results indicated cognitive impairment in all patients. SPECT analysis revealed multifocal hypoperfusion predominantly in the frontal, insular, and posterior cingulate regions in neurosyphilis patients compared with healthy controls (family-wise error corrected p < 0.05).Conclusions: Together with previous findings, our results suggest that the hypoperfusion in the frontal, insular, and posterior cingulate regions may reflect cognitive impairments observed in neurosyphilis patients. Further studies with larger samples are needed to confirm our findings.

scholarly journals EVALUATION OF REGIONAL CEREBRAL BLOOD FLOW BY SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN THE EARLY POSTOPERATIVE PERIOD OF SIMULTANEOUS REVASCULARIZATION OPERATIONS IN PATIENTS WITH COMBINED ATHEROSCLEROTIC LESIONS OF THE CAROTID AND CORONARY ARTERIES

2019 ◽  
Vol 34 (1) ◽  
pp. 85-91
Author(s):  
A. A. Korotkevich ◽  
S. E. Semenov ◽  
Yu. M. Portnov ◽  
N. I. Milinevskiy
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood ◽  
Atherosclerotic Lesions ◽  
Preoperative Stage ◽  
Photon Emission Computed Tomography

Aim. To evaluate the effect of simultaneous surgical intervention on regional cerebral blood flow (CBF) based on single photon emission computed tomography (SPECT).Material and Methods. The study included 14 patients with hemodynamically significant stenoses of the coronary and carotid arteries that underwent coronary artery bypass grafting concomitant with carotid endarterectomy. Brain SPECT with 99mTcHMPAO was performed twice: before surgery and in the postoperative period at days 5–7.Results. Overall, the group showed a statistically significant increase in regional cerebral blood flow in comparison with preoperative indicators in the area of the right caudate nucleus from 54.14±6.84 mL/100 g/min in the preoperative stage to 61.43±13.35 mL/100 g/min after surgery, p=0.037634, and in the left temporal lobe from 41.64±2.73 mL/100 g/min in the preoperative stage to 44.57±4.91 mL/100 g/min after surgery, p=0.019224. There were deviations of CBF less than 5 mL/100 g/min in 11 cases (79%) in most of the analyzed regions; the changes in cerebral blood flow were more pronounced in 3 cases: there was a diffuse increase in cerebral blood flow in 2 cases (14%) and а diffuse reduction of cerebral blood flow in 1 case (7%).Conclusion. Data obtained in a small sample of patients with combined atherosclerotic lesions of the carotid and coronary arteries preliminary suggest the absence of a statistically significant negative effect of simultaneous surgical intervention on the regional cerebral blood flow in all major basins of the cerebral arteries of the brain. Observed increase in the perfusion indices in the isolated analyzed zones, not exceeding 34%, may correspond to reactive benign postischemic hyperperfusion within the concept of reperfusion syndrome.

scholarly journals EVALUATION OF REGIONAL CEREBRAL BLOOD FLOW BY SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN THE EARLY POSTOPERATIVE PERIOD OF SIMULTANEOUS REVASCULARIZATION OPERATIONS IN PATIENTS WITH COMBINED ATHEROSCLEROTIC LESIONS OF THE CAROTID AND CORONARY ARTERIES

2019 ◽  
Vol 34 (1) ◽  
pp. 85-91
Author(s):  
A. A. Korotkevich ◽  
S. E. Semenov ◽  
Yu. M. Portnov ◽  
N. I. Milinevskiy
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood ◽  
Atherosclerotic Lesions ◽  
Preoperative Stage ◽  
Photon Emission Computed Tomography

Aim. To evaluate the effect of simultaneous surgical intervention on regional cerebral blood flow (CBF) based on single photon emission computed tomography (SPECT).Material and Methods. The study included 14 patients with hemodynamically significant stenoses of the coronary and carotid arteries that underwent coronary artery bypass grafting concomitant with carotid endarterectomy. Brain SPECT with 99mTcHMPAO was performed twice: before surgery and in the postoperative period at days 5–7.Results. Overall, the group showed a statistically significant increase in regional cerebral blood flow in comparison with preoperative indicators in the area of the right caudate nucleus from 54.14±6.84 mL/100 g/min in the preoperative stage to 61.43±13.35 mL/100 g/min after surgery, p=0.037634, and in the left temporal lobe from 41.64±2.73 mL/100 g/min in the preoperative stage to 44.57±4.91 mL/100 g/min after surgery, p=0.019224. There were deviations of CBF less than 5 mL/100 g/min in 11 cases (79%) in most of the analyzed regions; the changes in cerebral blood flow were more pronounced in 3 cases: there was a diffuse increase in cerebral blood flow in 2 cases (14%) and а diffuse reduction of cerebral blood flow in 1 case (7%).Conclusion. Data obtained in a small sample of patients with combined atherosclerotic lesions of the carotid and coronary arteries preliminary suggest the absence of a statistically significant negative effect of simultaneous surgical intervention on the regional cerebral blood flow in all major basins of the cerebral arteries of the brain. Observed increase in the perfusion indices in the isolated analyzed zones, not exceeding 34%, may correspond to reactive benign postischemic hyperperfusion within the concept of reperfusion syndrome.

Changes in regional cerebral blood flow distribution during postexercise hypotension in humans

2004 ◽  
Vol 96 (2) ◽  
pp. 719-724 ◽  
Author(s):  
J. W. Williamson ◽  
R. McColl ◽  
D. Mathews
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Perceived Exertion ◽  
Anterior Insula ◽  
Anterior Cingulate ◽  
Emission Computed Tomography ◽  
Exercise Recovery ◽  
Regional Cerebral Blood ◽  
Postexercise Hypotension

This investigation compared patterns of regional cerebral blood flow (rCBF) during exercise recovery both with and without postexercise hypotension (PEH). Eight subjects were studied on 3 days with randomly assigned conditions: 1) after 30 min of rest; 2) after 30 min of moderate exercise (M-Ex) at 60-70% heart rate (HR) reserve during PEH; and 3) after 30 min of light exercise (L-Ex) at 20% HR reserve with no PEH. Data were collected for HR, mean blood pressure (MBP), and ratings of perceived exertion and relaxation, and rCBF was assessed by use of single-photon-emission computed tomography. With the use of ANOVA across conditions, there were differences ( P < 0.05; mean ± SD) from rest during exercise recovery from M-Ex (HR = +12 ± 3 beats/min; MBP = -9 ± 2 mmHg), but not from L-Ex (HR = +2 ± 2 beats/min; MBP = -2 ± 2 mmHg). After M-Ex, there were decreases ( P < 0.05) for the anterior cingulate (-6.7 ± 2%), right and left inferior thalamus (-10 ± 3%), right inferior insula (-13 ± 3%), and left inferior anterior insula (-8 ± 3%), not observed after L-Ex. There were rCBF decreases for leg sensorimotor regions after both M-Ex (-15 ± 4%) and L-Ex (-12 ± 3%) and for the left superior anterior insula (-7 ± 3% and -6 ± 3%), respectively. Data show that there are rCBF reductions within specific regions of the insular cortex and anterior cingulate cortex coupled with a postexercise hypotensive response after M-Ex. Findings suggest that these cerebral cortical regions, previously implicated in cardiovascular regulation during exercise, may also be involved in PEH.

scholarly journals Noninvasive Quantitative Measurements of Regional Cerebral Blood Flow Using Technetium-99m-L,L-ECD SPECT Activated with Acetazolamide: Quantification Analysis by Equal-Volume-Split 99mTc-ECD Consecutive SPECT Method

1997 ◽  
Vol 17 (10) ◽  
pp. 1020-1032 ◽  
Author(s):  
Ryo Takeuchi ◽  
Hiroshi Matsuda ◽  
Yoshiharu Yonekura ◽  
Harumi Sakahara ◽  
Junji Konishi
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Statistical Significance ◽  
Photon Emission ◽  
Radionuclide Angiography ◽  
Vascular Lesions ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood ◽  
Technetium 99M

Resting- and acetazolamide (Acz)-activated-regional cerebral blood flow (rCBF) measurements were performed by consecutive single-photon emission computed tomography (SPECT) studies before and after Acz administration using equal-volume-split technetium-99m-L,L-ethyl cysteinate dimer. Quantitative rCBF images were converted from qualitative axial SPECT images by the application of Patlak plot graphical analysis with radionuclide angiography and Lassen's linearization correction. Total time span required for this study was 53 minutes. The unaffected side of 37 studies with unilateral vascular lesions and 45 studies without apparent vascular lesions showed 132 ± 17% and 140 ± 15% increase of mean CBF (mCBF), respectively, under Acz administration. Comparing these values, the Acz-activated rCBF increases of less-affected and affected hemispheres of 23 studies with bilateral vascular lesions (116 ± 13% and 113 ± 12%, respectively) was lower with high statistical significance ( P < 0.001). For the other 20 cases, physiologic saline was administered instead of Acz. This group showed no changes in mCBF under placebo administration (after placebo/baseline; 100 ± 6%). Acetazolamide-activated rCBF increase was recognized clearly and easily using quantitative images. This noninvasive method is easy to perform and may be helpful to detect regional abnormalities of hemodynamic reserve in cerebrovascular diseases.

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