Evaluation of Regional Cerebral Blood Flow in Alzheimer's Disease Patients with Subclinical Hypothyroidism

2015 ◽  
Vol 39 (5-6) ◽  
pp. 360-367 ◽  
Author(s):  
Megumi Haji ◽  
Noriyuki Kimura ◽  
Takuya Hanaoka ◽  
Yasuhiro Aso ◽  
Makoto Takemaru ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subclinical Hypothyroidism ◽  
Regional Cerebral Blood Flow ◽  
Photon Emission ◽  
Statistical Parametric Mapping ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood

Background: This study examined regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients with and without subclinical hypothyroidism (SCH). Methods: Eleven AD patients with SCH and 141 AD patients without SCH underwent brain perfusion single photon emission computed tomography (SPECT). The SPECT data were analyzed by statistical parametric mapping (SPM8) and FineSRT. Results: AD patients with SCH showed a significantly decreased rCBF mainly in the temporal lobe and thalamus, whereas those without SCH showed a significantly decreased rCBF in the parietotemporal lobe and cingulate gyrus as well as the frontal lobe. Conclusion: Our findings suggest that SCH may affect cerebral perfusion in regions associated with the memory function.

scholarly journals Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Teruyuki Matsuoka ◽  
Jin Narumoto ◽  
Keisuke Shibata ◽  
Aiko Okamura ◽  
Shogo Taniguchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Regional Cerebral Blood Flow ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Regional Cerebral Blood

The aim of this study was to examine the effect of toki-shakuyaku-san (TSS) on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single-photon emission computed tomography (SPECT). All subjects were administered TSS (7.5 g/day) for eight weeks. SPECT and evaluations using the Mini Mental State Examination (MMSE), Neuropsychiatric Inventory, and Physical Self-Maintenance Scale were performed before and after treatment with TSS. Three patients with MCI and five patients with AD completed the study. No adverse events occurred during the study period. After treatment with TSS, regional cerebral blood flow (rCBF) in the posterior cingulate was significantly higher than that before treatment. No brain region showed a significant decrease in rCBF. TSS treatment also tended to improve the score for orientation to place on the MMSE. These results suggest that TSS could be useful for treatment of MCI and AD.

Evaluation of the Image Feature Analysis Techniques by Image Strength Fluctuation for Alzheimer’s Disease

2021 ◽  
Vol 11 (6) ◽  
pp. 1541-1550
Author(s):  
Chang-Ching Yu ◽  
Hung-Pin Chan ◽  
Chien-Yi Ting
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Temporal Lobe ◽  
Single Photon ◽  
Photon Emission ◽  
Statistical Parametric Mapping ◽  
Image Feature ◽  
Emission Computed Tomography

This article compares the effectiveness of both image strength fluctuation (ISF) and statistical parametric mapping (SPM), which is used for analyzing cerebral blood flow traced by single photon emission computed tomography (SPECT) in patients with Alzheimer’s disease (AD). This is a retrospective study that uses the built-in SPECT template of the SPM software to analyze the differences in cerebral blood flow (CBF) between two groups after using the ISF and SPM software to normalize and smooth the data. Using Z score analysis, the ISF method revealed unusual fluctuations in the range of image strength. The hot and cold areas were considered to be the difference between normal and abnormal images and the analysis of the gray intensities of cold and hot areas was used to show that cold and hot were in characteristic locations that correlate with brain functional areas. The results of the SPM analysis revealed significantly reduced blood flow in the bilateral inferior parietal lobule, the middle or superior gyrus of the left temporal lobe, the superior gyrus and the sub-lobar insula of the right temporal lobe. The results from SPM were similar to those obtained with the ISF and indicated the same regions (83.3%).

Regional Cerebral Blood Flow and Prognostic Evaluation in Alzheimer’s Disease

2001 ◽  
Vol 12 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Flavio Nobili ◽  
Francesco Copello ◽  
Ferdinando Buffoni ◽  
Paolo Vitali ◽  
Nicola Girtler ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Prognostic Evaluation

scholarly journals Voxel-based investigations of regional cerebral blood flow abnormalities in Alzheimer's disease using a single-detector SPECT system

Clinics ◽  
2007 ◽  
Vol 62 (4) ◽  
pp. 377-384 ◽  
Author(s):  
Fabio L. S. Duran ◽  
Fernando G. Zampieri ◽  
Cassio C.M. Bottino ◽  
Carlos A. Buchpiguel ◽  
Geraldo F. Busatto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Single Detector ◽  
Spect System

Effects of nicergoline treatment on regional cerebral blood flow in early Alzheimer's disease

2019 ◽  
Vol 29 (3) ◽  
pp. 323-328
Author(s):  
Jooyeon J. Im ◽  
Hyeonseok Jeong ◽  
Jin Kyoung Oh ◽  
Yong‐An Chung ◽  
In‐Uk Song ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Early Alzheimer’S Disease
Sign in / Sign up

Export Citation Format

Share Document