Social Cognition in Patients with Amnestic Mild Cognitive Impairment and Mild Dementia of the Alzheimer Type

2021 ◽  
pp. 1-14
Author(s):  
Ann-Katrin Schild ◽  
Jenny Volk ◽  
Daniel Scharfenberg ◽  
Katrin Schuermann ◽  
Dix Meiberth ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Social Cognition ◽  
Mild Cognitive Impairment ◽  
Cognitive Theory ◽  
Amnestic Mild Cognitive Impairment ◽  
Analysis Of Covariance ◽  
Group Differences ◽  
Alzheimer Type ◽  
Cognitive Domains ◽  
Significant Impairment

Background: Social cognition (SC) is a core criterion for neurocognitive disorders. However, findings in patients with amnestic mild cognitive impairment (aMCI) and dementia of the Alzheimer type (DAT) are inconsistent. Objective: We report assessments of emotion recognition (ER), affective and cognitive theory of mind (ToM) in young (YC) and older controls (OC) compared to aMCI and DAT. Methods: 28 aMCI, 30 DAT, 30 YC, and 29 OC received tests of SC and a comprehensive neuropsychological assessment. Analysis of covariance was used to determine group differences. Multiple regression models were applied to identify predictors for each SC task. Results: In controls, OC performed worse in ER and both ToM tasks compared to YC except for one subtest. No significant differences were found between OC and patients concerning ER and affective ToM. In cognitive ToM, differences between OC and patients depended on content and cognitive load with significant impairment in DAT compared to OC. A cognitive composite score predicted SC in OC, but not in patients. Associations of SC with single cognitive domains were found in all groups with language and complex attention as best predictors. Not all variance of SC performance was explained by variance in cognitive domains. Conclusion: Lower performance on SC tasks in OC versus YC was confirmed, although not all tasks were equally affected. With progressive cognitive impairment, cognitive ToM is more impaired than ER or affective ToM. SC seems to be at least partly independent of other cognitive domains, justifying its inclusion in batteries for dementia diagnostic.

scholarly journals Dysexecutive mild cognitive impairment associated to frontal atrophy: Case report

2008 ◽  
Vol 2 (1) ◽  
pp. 76-79
Author(s):  
Marcio Luiz Figueredo Balthazar ◽  
Benito Pereira Damasceno
Keyword(s):  
Cognitive Impairment ◽  
Case Report ◽  
Mild Cognitive Impairment ◽  
Neurodegenerative Diseases ◽  
Daily Life ◽  
Amnestic Mild Cognitive Impairment ◽  
High Likelihood ◽  
Cognitive Domains ◽  
Daily Life Activities ◽  
Significant Impairment

Abstract Non-amnestic mild cognitive impairment (MCI) evolving to neurodegenerative diseases other than Alzheimer's disease (AD) is rarely well documented. We report a case of a 49 year-old woman who presented a slowly progressive attentional/dysexecutive syndrome sparing other cognitive domains and without significant impairment of daily life activities. Her mother had Parkinsonism and her brother, a psychotic syndrome. Brain CT/MRI showed frontal atrophy while brain SPECT showed moderate cortical hypoperfusion, mainly in the frontal lobes. Our case is an example of non-memory MCI whose neuropsychological data and brain imaging indicating high likelihood of progression to a non-AD dementia.

scholarly journals Prospective memory function in mild cognitive impairment and early dementia

2010 ◽  
Vol 16 (2) ◽  
pp. 318-325 ◽  
Author(s):  
CLAIRE THOMPSON ◽  
JULIE D. HENRY ◽  
PETER G. RENDELL ◽  
ADRIENNE WITHALL ◽  
HENRY BRODATY
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Memory Function ◽  
Absolute Magnitude ◽  
Task Demands ◽  
Group Differences ◽  
Significant Impairment ◽  
Prospective Remembering ◽  
And Control

AbstractWhen compared with controls, both mild cognitive impairment (MCI) and dementia are each associated with impaired memory for future intentions, or prospective memory (PM). However, prior studies have failed to agree on whether there are group differences in PM function between those with MCI and dementia. Furthermore, the degree and nature of the impairment remains to be clarified, as does the degree to which this impairment is secondary to deficits in other aspects of cognition. In the present study, MCI (n = 48), dementia (n = 39), and control participants (n = 53) were compared on Virtual Week, a measure that closely represents the types of PM tasks that occur in everyday life. Both clinical groups exhibited impairment irrespective of the specific task demands, but the magnitude of this deficit was greater for those with dementia. After covarying for other key cognitive parameters, although the absolute magnitude of the deficit was reduced, significant impairment remained. These results indicate that individuals with MCI, and to a greater extent dementia, experience generalized difficulties with PM. It is suggested that, while other cognitive deficits contribute to these difficulties, there is something unique to prospective remembering that may be additionally disrupted in these groups. (JINS, 2010, 16, 318–325.)

Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration

2007 ◽  
Vol 22 (12) ◽  
pp. 1217-1222 ◽  
Author(s):  
Luca Rozzini ◽  
Barbara Vicini Chilovi ◽  
Marta Conti ◽  
Erik Bertoletti ◽  
Ilenia Delrio ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type ◽  
Memory Deterioration
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