Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration

2007 ◽  
Vol 22 (12) ◽  
pp. 1217-1222 ◽  
Author(s):  
Luca Rozzini ◽  
Barbara Vicini Chilovi ◽  
Marta Conti ◽  
Erik Bertoletti ◽  
Ilenia Delrio ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type ◽  
Memory Deterioration

scholarly journals Platelet Amyloid Precursor Protein Abnormalities in Mild Cognitive Impairment Predict Conversion to Dementia of Alzheimer Type

2003 ◽  
Vol 60 (12) ◽  
pp. 1740 ◽  
Author(s):  
Barbara Borroni ◽  
Francesca Colciaghi ◽  
Carlo Caltagirone ◽  
Luca Rozzini ◽  
Laura Broglio ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

Social Cognition in Patients with Amnestic Mild Cognitive Impairment and Mild Dementia of the Alzheimer Type

2021 ◽  
pp. 1-14
Author(s):  
Ann-Katrin Schild ◽  
Jenny Volk ◽  
Daniel Scharfenberg ◽  
Katrin Schuermann ◽  
Dix Meiberth ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Social Cognition ◽  
Mild Cognitive Impairment ◽  
Cognitive Theory ◽  
Amnestic Mild Cognitive Impairment ◽  
Analysis Of Covariance ◽  
Group Differences ◽  
Alzheimer Type ◽  
Cognitive Domains ◽  
Significant Impairment

Background: Social cognition (SC) is a core criterion for neurocognitive disorders. However, findings in patients with amnestic mild cognitive impairment (aMCI) and dementia of the Alzheimer type (DAT) are inconsistent. Objective: We report assessments of emotion recognition (ER), affective and cognitive theory of mind (ToM) in young (YC) and older controls (OC) compared to aMCI and DAT. Methods: 28 aMCI, 30 DAT, 30 YC, and 29 OC received tests of SC and a comprehensive neuropsychological assessment. Analysis of covariance was used to determine group differences. Multiple regression models were applied to identify predictors for each SC task. Results: In controls, OC performed worse in ER and both ToM tasks compared to YC except for one subtest. No significant differences were found between OC and patients concerning ER and affective ToM. In cognitive ToM, differences between OC and patients depended on content and cognitive load with significant impairment in DAT compared to OC. A cognitive composite score predicted SC in OC, but not in patients. Associations of SC with single cognitive domains were found in all groups with language and complex attention as best predictors. Not all variance of SC performance was explained by variance in cognitive domains. Conclusion: Lower performance on SC tasks in OC versus YC was confirmed, although not all tasks were equally affected. With progressive cognitive impairment, cognitive ToM is more impaired than ER or affective ToM. SC seems to be at least partly independent of other cognitive domains, justifying its inclusion in batteries for dementia diagnostic.

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