The Effects of LW-AFC on Intestinal Microbiome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer’s Disease

2016 ◽  
Vol 53 (3) ◽  
pp. 907-919 ◽  
Author(s):  
Jianhui Wang ◽  
Fuqiang Ye ◽  
Xiaorui Cheng ◽  
Xiaorui Zhang ◽  
Feng Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Intestinal Microbiome ◽  
Model Of Alzheimer’S Disease ◽  
Senescence Accelerated Mouse

scholarly journals LW-AFC Effects on N-glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer’s Disease

2017 ◽  
Vol 8 (1) ◽  
pp. 101 ◽  
Author(s):  
Jianhui Wang ◽  
Xiaorui Cheng ◽  
Ju Zeng ◽  
Jiangbei Yuan ◽  
Zhongfu Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Glycan Profile ◽  
Model Of Alzheimer’S Disease ◽  
Senescence Accelerated Mouse

scholarly journals Sex-Dependent Effects of Intestinal Microbiome Manipulation in a Mouse Model of Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2370
Author(s):  
Harpreet Kaur ◽  
Suba Nookala ◽  
Surjeet Singh ◽  
Santhosh Mukundan ◽  
Kumi Nagamoto-Combs ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Performance ◽  
Intestinal Bacteria ◽  
Intestinal Microbiome ◽  
Fecal Microbiome ◽  
Model Of Alzheimer’S Disease ◽  
Probiotic Treatment ◽  
Plaque Load

Mechanisms linking intestinal bacteria and neurodegenerative diseases such as Alzheimer’s disease (AD) are still unclear. We hypothesized that intestinal dysbiosis might potentiate AD, and manipulating the microbiome to promote intestinal eubiosis and immune homeostasis may improve AD-related brain changes. This study assessed sex differences in the effects of oral probiotic, antibiotics, and synbiotic treatments in the AppNL-G-F mouse model of AD. The fecal microbiome demonstrated significant correlations between bacterial genera in AppNL-G-F mice and Aβ plaque load, gliosis, and memory performance. Female and not male AppNL-G-F mice fed probiotic but not synbiotic exhibited a decrease in Aβ plaques, microgliosis, brain TNF-α, and memory improvement compared to no treatment controls. Although antibiotics treatment did not produce these multiple changes in brain cytokines, memory, or gliosis, it did decrease Aβ plaque load and colon cytokines in AppNL-G-F males. The intestinal cytokine milieu and splenocyte phenotype of female but not male AppNL-G-F mice indicated a modest proinflammatory innate response following probiotic treatment compared to controls, with an adaptive response following antibiotics treatment in male AppNL-G-F mice. Overall, these results demonstrate the beneficial effects of probiotic only in AppNL-G-F females, with minimal benefits of antibiotics or synbiotic feeding in male or female mice.

Characterization of a 3xTg-AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background

Synapse ◽  
2018 ◽  
Vol 72 (4) ◽  
pp. e22025 ◽  
Author(s):  
Jessica Virgili ◽  
Meryem Lebbadi ◽  
Cyntia Tremblay ◽  
Isabelle St-Amour ◽  
Caroline Pierrisnard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model ◽  
Senescence Accelerated Mouse
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