scholarly journals The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease

2015 ◽  
Vol 46 (4) ◽  
pp. 877-888 ◽  
Author(s):  
Henrik H. Hansen ◽  
Katrine Fabricius ◽  
Pernille Barkholt ◽  
Michael L. Niehoff ◽  
John E. Morley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Receptor Agonist ◽  
Memory Function ◽  
Model Of Alzheimer’S Disease ◽  
Hippocampal Ca1 ◽  
Senescence Accelerated Mouse

Metformin Treatment Alters Memory Function in a Mouse Model of Alzheimer's Disease

2015 ◽  
Vol 44 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Kacee A. DiTacchio ◽  
Stephen F. Heinemann ◽  
Gustavo Dziewczapolski
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Function ◽  
Metformin Treatment ◽  
Model Of Alzheimer’S Disease

scholarly journals LW-AFC Effects on N-glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer’s Disease

2017 ◽  
Vol 8 (1) ◽  
pp. 101 ◽  
Author(s):  
Jianhui Wang ◽  
Xiaorui Cheng ◽  
Ju Zeng ◽  
Jiangbei Yuan ◽  
Zhongfu Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Glycan Profile ◽  
Model Of Alzheimer’S Disease ◽  
Senescence Accelerated Mouse

Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer’s disease

2019 ◽  
Vol 29 (2) ◽  
pp. 228-237 ◽  
Author(s):  
Juyong Kim ◽  
Siyoung Lee ◽  
Jaekyoon Kim ◽  
Sangwoo Ham ◽  
Jung Han Yoon Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nervous System ◽  
Mouse Model ◽  
Transient Receptor Potential ◽  
Memory Function ◽  
Amyloid Β ◽  
Neuronal Cultures ◽  
Transient Receptor Potential Vanilloid ◽  
Model Of Alzheimer’S Disease

Abstract The transient receptor potential vanilloid 1 (TRPV1) protein is a pain receptor that elicits a hot sensation when an organism eats the capsaicin of red chili peppers. This calcium (Ca2+)-permeable cation channel is mostly expressed in the peripheral nervous system sensory neurons but also in the central nervous system (e.g. hippocampus and cortex). Preclinical studies found that TRPV1 mediates behaviors associated with anxiety and depression. Loss of TRPV1 functionality increases expression of genes related to synaptic plasticity and neurogenesis. Thus, we hypothesized that TRPV1 deficiency may modulate Alzheimer’s disease (AD). We generated a triple-transgenic AD mouse model (3xTg-AD+/+) with wild-type (TRPV1+/+), hetero (TRPV1+/−) and knockout (TRPV1−/−) TRPV1 to investigate the role of TRPV1 in AD pathogenesis. We analyzed the animals’ memory function, hippocampal Ca2+ levels and amyloid-β (Aβ) and tau pathologies when they were 12 months old. We found that compared with 3xTg-AD−/−/TRPV1+/+ mice, 3xTg-AD+/+/TRPV1+/+ mice had memory impairment and increased levels of hippocampal Ca2+, Aβ and total and phosphorylated tau. However, 3xTg-AD+/+/TRPV1−/− mice had better memory function and lower levels of hippocampal Ca2+, Aβ, tau and p-tau, compared with 3xTg-AD+/+/TRPV1+/+ mice. Examination of 3xTg-AD-derived primary neuronal cultures revealed that the intracellular Ca2+ chelator BAPTA/AM and the TRPV1 antagonist capsazepine decreased the production of Aβ, tau and p-tau. Taken together, these results suggested that TRPV1 deficiency had anti-AD effects and promoted resilience to memory loss. These findings suggest that drugs or food components that modulate TRPV1 could be exploited as therapeutics to prevent or treat AD.

scholarly journals The dual GLP‐1/GIP receptor agonist DA4‐JC shows superior protective properties in the APP/PS1 mouse model of Alzheimer’s disease

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Mark Maskery ◽  
Simon Gengler ◽  
Elizabeth Mary Goulding ◽  
Josefine Ulrikke Melchiorsen ◽  
Mette M. Rosenkilde ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Receptor Agonist ◽  
Protective Properties ◽  
Model Of Alzheimer’S Disease ◽  
Gip Receptor
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