Usefulness of protein-based salivary markers in the diagnosis of oral potentially malignant disorders: A systematic review and meta-analysis

2021 ◽  
pp. 1-13
Author(s):  
Esteban Alexis Arroyo ◽  
Sergio Piñeiro Donís ◽  
Cintia M. Chamorro Petronacci ◽  
Monica G. Oliveira Alves ◽  
Xabier Marichalar Mendía ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Control Group ◽  
Cytokeratin 19 ◽  
Histopathological Diagnosis ◽  
Oral Potentially Malignant Disorders ◽  
Quantitative Expression ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Diagnostic Capacity ◽  
Meta Analyses

By using a meta-analytical approach, this study aimed to analyse the diagnostic capacity of protein-based biomarkers in saliva for the differential diagnosis of oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) from healthy individuals as control group (HCG). Articles on protein-based biomarkers in saliva, which provided quantitative expression in individuals with clinical and histopathological diagnosis of OPMD or oral leukoplakia (OL) were considered eligible. Searches were conducted in eight electronic databases. The methodological quality was assessed using the Quality Assessment of Diagnostic Studies tool (QUADAS-2). Functional analysis was also performed. Meta-analyses were performed using the OpenMeta tool (Analyst). Meta-analysis was possible for 4 of the 11 biomarkers studied. Only the carcinoembryonic antigen (CEA) and the soluble fragment of cytokeratin 19 (CYFRA21) were significant for the OSCC/OPMD subgroup, both with a very low heterogeneity. CEA had an OE = 25.854 (CI95%: 13.215–38.492, p< 0.001, I2 = 0) and CYFRA21 had an OE = 9.317 (CI95%: 9.014–9.619, p< 0.001, I2 = 0). For the OPMD/HCG subgroup, only CYFRA21 was significant, with an OE = 3.679 (CI95%: 0.663–6.696, p= 0.017) although with high heterogeneity (I2 = 91.24). The CEA and CYFRA21 markers proved very useful when differentiating OSCC from OPMD. The CYFRA21 was the only protein that was capable of distinguishing between OPMD and healthy controls.

scholarly journals ORAL POTENTIALLY MALIGNANT DISORDERS ASSOCIATED WITH BETEL QUID CHEWING HABIT IN SAMOSIR ISLAND, NORTH SUMATRA INDONESIA

2017 ◽  
Vol 20 (2) ◽  
pp. 72-79
Author(s):  
Indri Lubis ◽  
Ameta Primasari ◽  
Sayuti Hasibuan
Keyword(s):  
Health Centre ◽  
Betel Quid ◽  
Control Group ◽  
Oral Potentially Malignant Disorders ◽  
Public Health Centre ◽  
Increased Risk ◽  
Betel Quid Chewing ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
North Sumatra

Oral potentially malignant disorders have been associated with a betel quid chewing habit. To date, betel quid chewing has a major social and cultural role in the society of Samosir Island, North Sumatra, Indonesia. The purpose of the present study was to evaluate the occurrence of oral potentially malignant disorders associated with the habit of betel quid chewing in the society of Samosir Island, North Sumatra, Indonesia. This case-control study was conducted on all betel quid chewers in the working area of the Ambarita Public Health Centre in Samosir Regency, North Sumatra, Indonesia. All subjects were examined clinically for the presence of any oral lesions and interviewed for their betel quid chewing habit. Chi-square and Fisher’s exact tests were used to analyze the relationship between variables. Among the 51 subjects recruited in the study, 28 subjects suffered from oral potentially malignant disorders who had oral potentially malignant disorders such as submucous fibrosis and/or leukoplakia (the case group) whereas 23 subjects showed no clinically detectable oral potentially malignant disorders (the control group). An increased risk of oral potentially malignant disorders was associated with the habit of chewing areca nut and tobacco (OR=1.600; p=0.542), the duration of betel quid chewing more than 25 years (OR=4.379; p=0.023), and the frequency of betel quid chewing more than 6 times/day (OR=4.800; p=0.021). In conclusion, oral potentially malignant disorders were associated with chewing betel quid habit in the society of Samosir Island, North Sumatra, Indonesia.

scholarly journals In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (22) ◽  
pp. 11775
Author(s):  
Marta Mazur ◽  
Artnora Ndokaj ◽  
Divyambika Catakapatri Venugopal ◽  
Michela Roberto ◽  
Cristina Albu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Early Diagnosis ◽  
Search Strategy ◽  
Meta Analysis ◽  
Screening Method ◽  
Cochrane Library ◽  
Free Text ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

ASSESSMENT OF VIRULENCE FACTORS OF CANDIDIAL SPECIES AND ITS BIOTYPING IN ORAL POTENTIALLY MALIGNANT DISORDERS

2021 ◽  
pp. 51-54
Author(s):  
Afreen Jan ◽  
Anshi Jain ◽  
Rajvir Singh ◽  
Devi Charan Shetty ◽  
Saurabh Juneja
Keyword(s):  
Virulence Factors ◽  
Germ Tube ◽  
Lipolytic Activity ◽  
Study Groups ◽  
Control Group ◽  
Study Group ◽  
Oral Potentially Malignant Disorders ◽  
Tube Test ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

The aim of the study was to evaluate the virulence factors of candidal species and its biotypes associated with Oral Potentially Malignant Disorders. Materials and methods included that the present study comprised of red and white lesions (40) and normal healthy control group (5) individuals. Oral swabs were taken from representative area of the lesion to be used for both cytological, microbiological and biochemical tests. Samples were inoculated for fungal growth in Sabouraud Dextrose Agar and culture-positive samples had undergone for the germ tube test, chlymadospore formation and chrome agar test. The virulence factors were conrmed by Lipolytic, proteolytic, protinease and phospholipase tests. Anova test, Kruskall Wallis test and Post Hoc test were the statistical analysis used. The result showed that in this study group no candidial growth was found in control group, study group showed positive germ tube test formation, chlymadospore formation and chrom agar test. All positive isolates produced the four virulence factors with higher levels in candida albican isolates. The hemolytic activity in leukoplakia was found to be more virulent followed by Protienase activity amongst the group and within the study groups. Phospholipase activity amongst the study groups was found more virulent in Oral squamous cell carcinoma. Lipolytic activity was found more aggressive in Denture induced stomatitis amongst all the study group. It can be concluded that in this study there is a close association of Candida species with Oral potentially malignant disorders. The correlation of virulence properties of Candida with potentially malignant disorders has led to its role in its invasive potential.

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