scholarly journals Meta-analysis of the predictive value of DNA aneuploidy in malignant transformation of oral potentially malignant disorders

2017 ◽  
Vol 47 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Nader A. Alaizari ◽  
Marcelo Sperandio ◽  
Edward W. Odell ◽  
Daiane Peruzzo ◽  
Sadeq A. Al-Maweri
Keyword(s):  
Malignant Transformation ◽  
Predictive Value ◽  
Meta Analysis ◽  
Oral Potentially Malignant Disorders ◽  
Dna Aneuploidy ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Predictive Value of Dysplasia Grading and DNA Ploidy in Malignant Transformation of Oral Potentially Malignant Disorders

2013 ◽  
Vol 6 (8) ◽  
pp. 822-831 ◽  
Author(s):  
Marcelo Sperandio ◽  
Amy L. Brown ◽  
Claire Lock ◽  
Peter R. Morgan ◽  
Victoria H. Coupland ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Predictive Value ◽  
Dna Ploidy ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals DNA Methylation Patterns in Saliva of Tobacco users with High-Risk Oral Potentially Malignant Disorders

2021 ◽  
pp. 129-137
Author(s):  
Mimansha Patel ◽  
Madhuri Nitin Gawande ◽  
Minal Shashikant Chaudhary ◽  
Alka Harish Hande
Keyword(s):  
Dna Methylation ◽  
High Risk ◽  
Malignant Transformation ◽  
Promoter Methylation ◽  
Genomic Dna ◽  
Premalignant Lesions ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Methylation Patterns

Background: “Oral Potentially Malignant Disorder (OPMD)” is a well-known symptom that, if untreated, can be carcinogenic. It includes leukoplakia, erythroplakia or erythroleukoplakia. One of the typical premalignant lesions of the oral cavity is “oral leukoplakias (OLs),” which frequently precedes “OSCCs.”OLs with dysplastic characteristics are considered to be at a higher risk of “malignant transformation.” So, early diagnosis of "oral squamous cell carcinomas (OSCCs)" is desperately required to enhance patient prognosis and quality of life (QOL).As a result, we examined the distinctive promoter methylation presence in high-risk OLs. Objectives: To detect, compare & correlate “DNA methylation” patterns in normal individuals, tobacco users without disease and tobacco users with the disease. Methodology: With the participants' full consent, 48 saliva samples were obtained and prepared. DNA isolation, restriction digestion of genomic DNA, extraction of restriction enzyme digested genomic DNA, Polymerase Chain Reaction (PCR), and Agarose Gel Electrophoresis (AGE) were all carried out. Expected results: This study will help us to assess the use of Saliva as an aid to identifying both high and low risk “Oral Potentially Malignant Disorders.” Conclusion: Peculiar promoter methylation of various genes was related to a high possibility of malignant transformation in OLs.

scholarly journals The role of interventional surgery in oral potentially malignant disorders

2014 ◽  
Vol 5 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Peter Thomson
Keyword(s):  
Malignant Transformation ◽  
Scientific Literature ◽  
Squamous Carcinoma ◽  
Oral Potentially Malignant Disorders ◽  
Management Guidelines ◽  
Increased Risk ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Rising Incidence

Oral potentially malignant disorders are mucosal diseases with a significantly increased risk of squamous carcinoma development – a lethal and deforming disease with rising incidence, especially in young people. Despite the ability to recognise pre-cancer disorders in patients, clinicians remain unable to predict individual mucosal lesion behaviour or quantify the risk of malignant transformation. No clear management guidelines exist and the available scientific literature is unable to answer the fundamental question: does early diagnosis and interventional management treat pre-cancer effectively and prevent malignant transformation?

Predictive value of CCND1 /cyclin D1 alterations in the malignant transformation of potentially malignant head and neck disorders: Systematic review and meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3395-3407 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Ángela Ayén ◽  
Lucía González‐Ruiz ◽  
José Antonio Gil‐Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cyclin D1 ◽  
Head And Neck ◽  
Malignant Transformation ◽  
Predictive Value ◽  
Meta Analysis ◽  
Potentially Malignant ◽  
Neck Disorders

scholarly journals In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (22) ◽  
pp. 11775
Author(s):  
Marta Mazur ◽  
Artnora Ndokaj ◽  
Divyambika Catakapatri Venugopal ◽  
Michela Roberto ◽  
Cristina Albu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Early Diagnosis ◽  
Search Strategy ◽  
Meta Analysis ◽  
Screening Method ◽  
Cochrane Library ◽  
Free Text ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

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