scholarly journals Financial Capacity and Illiteracy: Does Education Matter in Amnestic Mild Cognitive Impairment?

2021 ◽  
pp. 1-5
Author(s):  
Vaitsa Giannouli ◽  
Magda Tsolaki
Keyword(s):  
Cognitive Impairment ◽  
High Education ◽  
Mild Cognitive Impairment ◽  
Formal Education ◽  
Amnestic Mild Cognitive Impairment ◽  
Potential Influence ◽  
Financial Capacity ◽  
Low Education ◽  
Amci Group ◽  
Multiple Domain

Neuropsychological assessment in amnestic mild cognitive impairment (aMCI) becomes complicated when education-literacy is taken into consideration. This study sought to explore the potential influence of literacy/illiteracy and education on financial capacity in patients with multiple-domain aMCI. Six groups consisting of aMCI (illiterate-no formal education, literate with low education, and literate with high education) and non-demented controls were examined. Literacy has an effect on financial capacity, as the illiterate aMCI group alone had the lowest scores in a financial capacity test resembling the performance of patients with mild Alzheimer’s disease. In controls there was a similar pattern, but all three healthy groups regardless of education scored above the cut-off score for incapacity.

Cortical thickness in single- versus multiple-domain amnestic mild cognitive impairment

NeuroImage ◽  
2007 ◽  
Vol 36 (2) ◽  
pp. 289-297 ◽  
Author(s):  
Sang Won Seo ◽  
Kiho Im ◽  
Jong-Min Lee ◽  
Yun-Hee Kim ◽  
Sung Tae Kim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cortical Thickness ◽  
Amnestic Mild Cognitive Impairment ◽  
Single Versus ◽  
Multiple Domain

scholarly journals Financial Capacity of Older African Americans With Amnestic Mild Cognitive Impairment

2010 ◽  
Vol 24 (4) ◽  
pp. 365-371 ◽  
Author(s):  
Kristen L. Triebel ◽  
Ozioma C. Okonkwo ◽  
Roy Martin ◽  
Henry Randall Griffith ◽  
Martha Crowther ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
African Americans ◽  
Amnestic Mild Cognitive Impairment ◽  
Financial Capacity ◽  
Older African Americans

scholarly journals Single- and Multiple-Domain Amnestic Mild Cognitive Impairment: Two Sides of the Same Coin?

2009 ◽  
Vol 28 (6) ◽  
pp. 541-549 ◽  
Author(s):  
Simona Maria Brambati ◽  
Sylvie Belleville ◽  
Marie-Jeanne Kergoat ◽  
Céline Chayer ◽  
Serge Gauthier ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Two Sides ◽  
Multiple Domain

scholarly journals Sex differences in cortisol and memory following acute social stress in amnestic mild cognitive impairment

2019 ◽  
Author(s):  
Kelly J. Murphy ◽  
Travis E. Hodges ◽  
Paul A.S. Sheppard ◽  
Angela K. Troyer ◽  
Elizabeth Hampson ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Social Stress ◽  
Spatial Working Memory ◽  
Memory Function ◽  
Amnestic Mild Cognitive Impairment ◽  
Amci Group ◽  
The Relationship

AbstractObjectiveOlder adults with amnestic mild cognitive impairment (aMCI) develop Alzheimer’s type dementia approximately ten times faster annually than the normal population. Adrenal hormones are associated with aging and cognition. We investigated the relationship between acute stress, cortisol, and memory function in aMCI with an exploratory analysis of sex.MethodSalivary cortisol was sampled diurnally and during two test sessions, one session with the Trier Social Stress Test (TSST), to explore differences in the relationship between cortisol and memory function in age-normal cognition (NA) and aMCI. Participants with aMCI (n=6 women, 9 men; mean age=75) or similarly aged NA (n=9 women, 7 men, mean age=75) were given tests of episodic, associative, and spatial working memory with a psychosocial stressor (TSST) in the second session.ResultsThe aMCI group performed worse on the memory tests than NA as expected, and males with aMCI had elevated cortisol levels on test days. Immediate episodic memory was enhanced by social stress in NA but not in the aMCI group, indicating that stress-induced alterations in memory are different in individuals with aMCI. High cortisol was associated with impaired performance on episodic memory in aMCI males only. Cortisol in Session 1 moderated the relationship with spatial working memory, whereby higher cortisol was associated with worse performance in NA, but better spatial working memory in aMCI. In addition, effects of aMCI on perceived anxiety in response to stress exposure were moderated by stress-induced cortisol in a sex-specific manner.ConclusionsWe show effects of aMCI on Test Session cortisol levels and effects on perceived anxiety, and stress-induced impairments in memory in males with aMCI in our exploratory sample. Future studies should explore sex as a biological variable as our findings suggests that effects at the confluence of aMCI and stress can be obfuscated without sex as a consideration.

The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Lijuan Gao ◽  
Lihua Gu ◽  
Hao Shu ◽  
Jiu Chen ◽  
Jianli Zhu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Parahippocampal Gyrus ◽  
Structural Basis ◽  
P300 Latency ◽  
Information Processing Speed ◽  
Amci Group ◽  
The Relationship

Abstract Background Amnestic mild cognitive impairment (aMCI) is characterized by delayed P300 latency and reduced grey matter (GM) volume, respectively. The relationship between the features in aMCI is unclear. This study was to investigate the relationship between the altered P300 latency and the GM volume in aMCI. Methods Thirty-four aMCI and 34 well-matched normal controls (NC) were studied using electroencephalogram during a visual oddball task and scanned with MRI. Both tests were finished in the same day. Results As compared with the NC group, the aMCI group exhibited delayed P300 latency in parietal cortex and reduced GM volumes in bilateral temporal pole and left hippocampus/parahippocampal gyrus. A remarkable negative correlation was found between delayed P300 latency and reduced left hippocampal volume only in the aMCI group. Interestingly, the mediating analysis found P300 latency significantly mediated the association between right supramarginal gyrus volume and information processing speed indicated by Stroop Color and Word Test A scores. Conclusions The association between delayed P300 latency and reduced left hippocampal volume in aMCI subjects suggests that reduced left hippocampal volume may be the potential structural basis of delayed P300 latency.

Hippocampal Subfield Atrophy in Multi-Domain but Not Amnestic Mild Cognitive Impairment

2015 ◽  
Vol 40 (1-2) ◽  
pp. 44-53 ◽  
Author(s):  
Carl Fredrik Eliassen ◽  
Per Selnes ◽  
Ina Selseth Almdahl ◽  
Ivar Reinvang ◽  
Tormod Fladby ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Dentate Gyrus ◽  
Amnestic Mild Cognitive Impairment ◽  
Clinical Progression ◽  
Amnestic Mci ◽  
Cornu Ammonis ◽  
Amci Group

Background/Aims: To investigate differences in hippocampal (HP) subfields and the adjoining perirhinal and entorhinal cortices (PRC and ERC) between amnestic mild cognitive impairment (aMCI) and multi-domain amnestic MCI (mdMCI) patients, and controls. Methods: Nineteen patients characterized as aMCI were compared with 24 mdMCI patients and 31 controls by means of an automatic HP segmentation procedure. Results: We found significant atrophy of the PRC and ERC in aMCI relative to controls, whereas a more pronounced pattern of atrophy in most subfields, including total HP volume, was found in the mdMCI group. The mdMCI group also had a significant cornu ammonis sector 4 region with dentate gyrus, subiculum and total HP atrophy relative to aMCI. Conclusion: The aMCI group showed atrophy in the PRC and ERC, whereas significantly more affection of the HP subfields was evident in mdMCI. The mdMCI group may thus represent clinical progression relative to aMCI coupled with HP subfield affection.

Reaction time intra-individual variability reveals inhibitory deficits in single- and multiple-domain amnestic mild cognitive impairment

2021 ◽  
Author(s):  
Ricky Chow ◽  
Rahel Rabi ◽  
Shahier Paracha ◽  
Brandon P Vasquez ◽  
Lynn Hasher ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Response Inhibition ◽  
Individual Variability ◽  
Amnestic Mild Cognitive Impairment ◽  
Healthy Controls ◽  
Interference Control ◽  
Inhibitory Deficits ◽  
Report Data ◽  
Multiple Domain

Abstract Objectives Amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer’s disease and other dementias, is characterized by episodic memory impairment. Recent evidence has shown inhibitory control deficits in aMCI, but the extent of these deficits across inhibitory domains (i.e., response inhibition and interference control) and aMCI subtypes (i.e., single- versus multiple-domain) remains unclear. Few studies have included response time intra-individual variability (RT IIV) in these efforts. The aim of this study was to compare response inhibition and interference control between aMCI subtypes using measures of accuracy, mean RT, and RT IIV. Method We report data from 34 individuals with single-domain aMCI (sdaMCI, 66–86 years), 20 individuals with multiple-domain aMCI (mdaMCI, 68–88 years), and 52 healthy controls (64–88 years) who completed tasks of response inhibition (Go-NoGo) and interference control (Flanker). Group differences in accuracy, mean RT, and RT IIV were examined for both tasks. Results Individuals with mdaMCI had higher RT IIV than the other groups on both tasks. In RT IIV, we observed an interference control deficit in mdaMCI and sdaMCI relative to healthy controls, a finding not observed through accuracy or mean RT. Discussion RT IIV may detect subtle differences in inhibition deficits between aMCI subtypes that may not be evident with conventional behavioral measures. Findings support the supplementary use of RT IIV when assessing early executive function deficits.

scholarly journals Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Chih-Sung Liang ◽  
Chia-Lin Tsai ◽  
Guan-Yu Lin ◽  
Jiunn-Tay Lee ◽  
Yu-Kai Lin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Interleukin 2 ◽  
Amnestic Mild Cognitive Impairment ◽  
Protein Biomarkers ◽  
Roc Curve Analysis ◽  
Amci Group ◽  
Baseline Levels ◽  
Discriminatory Capacity

The rate of cognitive decline among patients with amnestic mild cognitive impairment (aMCI) varies, and it is thus crucial to accurately predict the probability of cognitive deterioration in patients with MCI. We compared the potential of cytokines with amyloid beta (Aβ) and tau biomarkers for predicting cognitive decline in patients with aMCI or Alzheimer’s disease (AD). All participants (controls, aMCI, and AD patients) underwent plasma biomarker examinations for Aβ1–40, Aβ1–42, total tau (t-tau), tau phosphorylated at threonine 181 [p-Tau181]), and 29 cytokines and baseline cognitive tests, including Mini-Mental State Examination (MMSE). The correlation between biomarker levels and annual MMSE change during the follow-up was examined. Receiver operating characteristic (ROC) curve analysis was performed to determine whether the statistically significant plasma biomarkers could identify cognitive decline. Higher baseline levels of IL-2, sCD40L, IL-8, and VEGF were associated with a lower annual cognitive decline in the aMCI group, and higher baseline levels of Aβ1–40, IFNγ, IL-5, IL-17A, IL-25, and FGF were associated with a rapid annual cognitive decline in the AD group. IL-2 had a high discriminatory capacity for identifying cognitive decline, with an area under curve (AUC) of 85.7% in the aMCI group, and the AUC was slightly increased when combining IL-2 with Aβ or tau biomarkers. However, none of the biomarkers had a satisfactory discriminatory capacity in the AD group. IL-2 may have a better discriminatory capacity for identifying cognitive decline than Aβ and tau biomarkers in patients with aMCI.

scholarly journals Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

2020 ◽  
Author(s):  
Hao Shu ◽  
Lihua Gu ◽  
Ping Yang ◽  
Molly V. Lucas ◽  
Lijuan Gao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Activity Pattern ◽  
Temporal Dynamics ◽  
Amnestic Mild Cognitive Impairment ◽  
Episodic Retrieval ◽  
Amci Group ◽  
Familiarity And Recollection ◽  
Spatial Activity Pattern ◽  
Fmri Analysis

Abstract Background Episodic memory (EM) deficit is the core cognitive dysfunction of amnestic mild cognitive impairment (aMCI). However, the episodic retrieval circuit detected by functional MRI (fMRI) appears preserved in aMCI subjects. To address this discrepancy, this study employed simultaneous electroencephalography (EEG)-fMRI recording to determine whether temporal dynamics of brain episodic retrieval activity were disturbed in patients with aMCI. Methods Twenty-six aMCI and 29 healthy control (HC) subjects completed a word-list memory retrieval task during simultaneous EEG-fMRI. The retrieval success activation pattern was detected with fMRI analysis, and the familiarity- and recollection-related components of episodic retrieval activity were identified using event-related potential (ERP) analysis. The fMRI-constrained ERP analysis explored the temporal dynamics of brain activity in the retrieval success pattern, and the ERP-informed fMRI analysis detected fMRI correlates of the ERP components related to familiarity and recollection processes. Results The two groups exhibited similar retrieval success patterns in the bilateral posteromedial parietal cortex, the left inferior parietal lobule (IPL), and the left lateral prefrontal cortex (LPFC). The fMRI-constrained ERP analysis showed that the aMCI group did not exhibit old/new effects in the IPL and LPFC that were observed in the HC group. In addition, the aMCI group showed decreased fMRI activity in the precuneus and left hippocampus related to ERP familiarity and recollection components, respectively. Conclusions This study identified disturbed temporal dynamics in episodic retrieval activity with a preserved spatial activity pattern in aMCI. Taken together, the simultaneous EEG-fMRI technique demonstrated the potential to identify individuals with a high risk of cognitive deterioration.

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