scholarly journals Ferulic Acid: Therapeutic Potential Through Its Antioxidant Property

2007 ◽  
Vol 40 (2) ◽  
pp. 92-100 ◽  
Author(s):  
Marimuthu Srinivasan ◽  
Adluri R. Sudheer ◽  
Venugopal P. Menon
Keyword(s):  
Ferulic Acid ◽  
Therapeutic Potential ◽  
Antioxidant Property

Ferulic Acid: A Promising Therapeutic Phytochemical and Recent Patents Advances

2019 ◽  
Vol 13 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Ashun Chaudhary ◽  
Vivek S. Jaswal ◽  
Sonika Choudhary ◽  
Sonika ◽  
Ajay Sharma ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Sweet Corn ◽  
Therapeutic Potential ◽  
Antioxidant Property ◽  
Present Review ◽  
Rice Grain ◽  
Oxidative Damages ◽  
Antioxidant Agent ◽  
Ferulic Acids

Background: Among the various phenolics metabolites, ferulic acid is considered as the promising mitigating, restorative and antioxidant agent. Ferulic acid is one of the most commonly found natural products in vegetables, for example, tomatoes, sweet corn, and in rice grain. Phytochemicals are utilized in the treatment of human ailments and these are derived from the dietary compounds. Objective: The present review widely argued the calming restorative capability of ferulic acid alongside the scientific evidences and its proposed mechanism for activity. Furthermore, we provided the main practical points for the use of ferulic acid in oxidative damages during various diseases. Additionally, the relevant patents on ferulic acid with various therapeutic potential has been discussed. Methods: One hundred and twenty references have been cited in the present review article. The cited references were found to be suitable and described the therapeutic application of ferulic acid thoroughly. Conclusion: Ferulic acids are known to contrarily down-manage an assortment of extracellular and intrcelullular molecular targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like malignant growth, diabetes, cardiovascular and neurodegenerative diseases. The current review deals with the antioxidant property of ferulic acid and the recent patent describes the role of ferulic acid against human diseases.

scholarly journals Effective Utilization of Pineapple Waste, Evaluation of Ferulic Acid, Micro Nutrients and Antioxidant Property

2020 ◽  
Vol 2 (1) ◽  
pp. 30
Keyword(s):  
Antioxidant Activity ◽  
Ferulic Acid ◽  
High Performance ◽  
Soxhlet Extraction ◽  
Antioxidant Property ◽  
Extraction Process ◽  
Fruit Peel ◽  
Manganese Zinc ◽  
Pineapple Peel ◽  
Phosphorus Iron

India is the second-largest producer of fruit and vegetable producers. Usually, after fruit intake, fruit peel is left as waste. The main bioactive components of pineapple are phenolic compounds, β-carotene, ascorbic acid, and flavonoids. Ferulic acid is a phenolic acid widely used in the nutritional and cosmetic fields. In this study, pineapple peel was dried, powdered, and vitamin content (A, B, B1, B2, B6, B12 & C), calcium, potassium, phosphorus, iron, manganese, zinc and food fiber were analyzed. Moreover, in the present study, traditional and non-conventional processes such as Soxhlet extraction, supreme fluid extraction, and normal solvent extraction was used for the extraction of ferulic acid, which is a precursor for vanillin synthesis. The quantification of ferulic acid was done by High performance fluid chromatographic (HPL C) method. After the above-mentioned extraction process overall phenolic and antioxidant activity were also evaluated and compared. The highest concentrations of ferulic acid (0.7696g/100 g), phenolic compound (2.365mg / GAE), antioxidant activity (45 percent), and yield (90.5 %) were obtained for Soxhlet extraction using methanol.

scholarly journals Antioxidant Effects of Protocatechuic Acid and Protocatechuic Aldehyde: Old Wine in a New Bottle

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Shijun Zhang ◽  
Zhibo Gai ◽  
Ting Gui ◽  
Juanli Chen ◽  
Qingfa Chen ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Protocatechuic Acid ◽  
Therapeutic Potential ◽  
Antioxidant Property ◽  
Biological Properties ◽  
Structural Variations ◽  
Beneficial Effects ◽  
Protocatechuic Aldehyde

Phenolic compounds are naturally present as secondary metabolites in plant-based sources such as fruits, vegetables, and spices. They have received considerable attention for their antioxidant, anti-inflammatory, and anti-carcinogenic properties for protection against many chronic disorders such as neurodegenerative diseases, diabetes, cardiovascular diseases, and cancer. They are categorized into various groups based on their chemical structure and include phenolic acids, flavonoids, curcumins, tannins, and quinolones. Their structural variations contribute to their specific beneficial effects on human health. The antioxidant property of phenolic compounds protects against oxidative stress by up-regulation of endogenous antioxidants, scavenging free radicals, and anti-apoptotic activity. Protocatechuic acid (PCA; 3,4-dihydroxy benzoic acid) and protocatechuic aldehyde (PAL; 3,4-dihydroxybenzaldehyde) are naturally occurring polyphenols found in vegetables, fruits, and herbs. PCA and PAL are the primary metabolites of anthocyanins and proanthocyanidins, which have been shown to possess pharmacological actions including antioxidant activity in vitro and in vivo. This review aims to explore the therapeutic potential of PCA and PAL by comprehensively summarizing their pharmacological properties reported to date, with an emphasis on their mechanisms of action and biological properties.

Therapeutic Potential of Ferulic Acid in Alzheimer's Disease

2021 ◽  
Vol 19 ◽  
Author(s):  
Hasan Turkez ◽  
Mehmet Enes Arslan ◽  
Joice Nascimento Barboza ◽  
Cigdem Yuce Kahraman ◽  
Damiao Pergentino de Sousa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Free Radical ◽  
Ferulic Acid ◽  
Therapeutic Potential ◽  
High Capacity ◽  
Biological Properties ◽  
Tau Proteins ◽  
Phosphorylated Tau ◽  
Anti Inflammatory

Abstract: Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases and it covers 60% of whole dementia cases. AD is a constantly progressing neurodegenerative disease as a result of the production of β-amyloid (Aβ) protein and the accumulation of hyper-phosphorylated Tau protein; it causes breakages in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment or slowdown. Over the last decade, multiple target applications have been developed for AD treatments. These targets include Aβ accumulations, hyper-phosphorylated Tau proteins, mitochondrial dysfunction, and oxidative stress resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from Aβ induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity antioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerted neuroprotection via preventing Aβ-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in Aβ-induced neurotoxicity, protection against free radical attacks, and enzyme inhibitions and describe them as possible therapeutic agents for the treatment of AD.

scholarly journals In-Vitro Wound Healing, Antioxidants, Antibacterial and Cytotoxic Activity of Probiotic Bacteria Isolated from Spoiled Curd

2020 ◽  
Vol 2 (1) ◽  
pp. 76
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
Antioxidant Property ◽  
Diffusion Method ◽  
Dilution Method ◽  
Safe Alternative ◽  
Cutaneous Wounds ◽  
Healing Property ◽  
New Perspective

Lactic acid bacteria (LAB) isolated from curd has emerged as a welcome source of antimicrobials and therapeutics and is accepted as probiotics. Probiotics have been associated with improved healing of intestinal ulcers and healing of infected cutaneous wounds. Therefore this current study was undertaken to assess the antibacterial, antioxidant, minimum inhibitory concentration and cytotoxicity efficacy of Lactobacilli isolated from spoiled curd sample. The bacteria was isolated using serial dilution method and the antagonistic properties of these isolates against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined using agar well diffusion method. Amongst the 8 isolates, C3 exhibited the highest antibacterial activity against all the pathogens. It was then tested for antioxidant property using DPPH assay and also found wound healing property using 3T3 cell line. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by cutaneous wounds.

In Vitro Antioxidant, Anti-Inflammatory And Anti-Microbial Activity of Carica Papaya Seeds

2020 ◽  
pp. 19-38 ◽  
Author(s):  
Pooja G. Singh ◽  
Madhu S. B ◽  
Shailasreesekhar Shailasreesekhar ◽  
Gopenath TS ◽  
Kanthesh M. Basalingappa ◽  
...  
Keyword(s):  
Carica Papaya ◽  
Therapeutic Potential ◽  
Reducing Power ◽  
In Vitro Study ◽  
Antioxidant Property ◽  
Total Phenolic ◽  
Dpph Method ◽  
Papaya Seeds ◽  
Anti Inflammatory

Papaya seeds are reported to have higher therapeutic potential in comparison to the fruits in which they reside. Thus, the present in-vitro study aimed to evaluate and compare the anti-oxidant, anti-inflammatory and anti-microbial effect of seed extracts on Carica papaya L. (Caricaceae). The bioactive form the seeds were sequentially fractionated with hexane, chloroform, diethyl ether, and methanol in the increasing order of polarity. Total phenolic and flavonoid contents were estimated. These extracts were assessed for an antioxidant property by 1, 1-diphenyl-2-picryl-hydroxyl (DPPH) method and reducing power assay was carried out using the FeCl3 method. Inhibition of 15-lipoxygenase (LOX) by these extracts at 5 -25μg to asses anti-inflammatory capacity was studied.

scholarly journals Biotransformation of Indigo Pigment by Indigenously Isolated Pseudomonas sp. HAV-1 and Assessment of Its Antioxidant Property

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Aditi Dua ◽  
Kishor Chauhan ◽  
Hilor Pathak
Keyword(s):  
Ascorbic Acid ◽  
Therapeutic Potential ◽  
Growth Parameters ◽  
Analytical Techniques ◽  
Antioxidant Property ◽  
Pseudomonas Sp ◽  
Environment Friendly ◽  
Green Production ◽  
Indigo Production ◽  
Human Health Effects

Chemical synthesis of indigo poses harsh environmental hazards and adverse human health effects. This necessitates an environment-friendly and producer-friendly approach for indigo production. The present study was thus significant as it reports an indigenously isolated potential indigo pigment producing culture identified as Pseudomonas sp. HAV-1 with noteworthy antioxidant property. The bioindigo pigment was characterized using various analytical techniques. The pigment production was enhanced from 412 μg mL−1 to 700 μg mL−1 by optimizing the growth parameters. Furthermore, the antioxidant property of indigo pigment is hitherto unexplored. This property can significantly append to its therapeutic potential. The bioindigo pigment produced by Pseudomonas sp. HAV-1 depicted 2.2 μM ascorbic acid equivalent antioxidant property. More to the point, the present work addresses a footstep towards green production of indigo.

scholarly journals Phytochemical screening, mineral composition and in vitro antioxidant activities of Pterocarpus mildbraedii leaves

2016 ◽  
Vol 4 (1) ◽  
pp. 23 ◽  
Author(s):  
Usunomena Usunobun ◽  
Igwe V. Chinwe
Keyword(s):  
Therapeutic Potential ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Antioxidant Property ◽  
Phytochemical Screening ◽  
Mineral Analysis ◽  
Biochemical Basis

Background: Pterocarpus mildbraedii is used in some Nigerian tribes in the treatment of headaches, pains, fever, convulsions, and respiratory disorders. This study was carried out to ascertain the phytochemicals, minerals and in vitro antioxidant activities of Pterocarpus mildbraedii leaves.Methods: Qualitative phytochemical screening was carried out using standard procedures while Mineral analysis was carried out using Atomic Absorption Spectrophotometer (AAS). Also, antioxidant activities of Pterocarpus mildbraedii leaves were evaluated using reducing power ability and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays.Results: Result on phytochemicals reveals the presence of flavonoids, saponins, alkaloids, tannins. Mineral analysis showed calcium (1283mg/kg) to be higher in concentration and manganese (4mg/kg) least in concentration (4mg/kg). Other analysed minerals include sodium (603mg/kg), potassium (1048mg/kg), magnesium (778mg/kg), zinc (25mg/kg), iron (146mg/kg), phosphates (1002mg/kg), etc. In vitro antioxidant activity results show that Pterocarpus mildbraedii possess potent but dose-dependent reducing power ability and free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.Conclusion: The presence of phytochemicals such as flavonoids, saponins, alkaloids and tannins in Pterocarpus mildbraedii provides some biochemical basis for the ethno pharmacological uses of the plant. Also the information provided in this research study may help to spread the ethno botanical uses of Pterocarpus mildbraedii leaves to other parts of the World. The findings clearly demonstrate that Pterocarpus mildbraedii leaves have promising antioxidant property and needs further evaluation to exploit its therapeutic potential.

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