The Potential Health Benefits of Papaya Seeds

Papaya (Carica papaya) is a tropical fruit having commercial importance because of its high nutritive and medicinal value. Papaya seeds are traditionally used by human beings from centuries to heal many illnesses. Papaya seeds contains antioxidants and antimicrobial virtues which gives protection against harmful free radicals and reduce rate of cancer and heart disease. Papaya seeds contain a variety of essential macro and micronutrients. The papaya seeds contain large amounts of nutrients, including fibre which is effective for combating constipation and other digestive problems. Seeds can be used to treat health complications such as urinary tract infection, candidiasis and sepsis. Papaya seeds are sometimes used in salads and can even be used as a substitute for black pepper. Products developed from papaya seeds are considered to be nutritionally rich with diverse sources of all nutrients. Papaya seeds have the potential to produce oil with nutritional and functional properties highly similar to olive oil. The papaya seed, and products may be useful for bio-fuel, medicinal and industrial purposes. Therefore, Papaya seeds are usually thrown away but their proper utilization can lead to the development of novel drug in medicine and considered as safe for consumption. ‘In this review subtopics covered are nutritional and Phytochemicals composition, antioxidant effect, antibacterial Activity, anthelminthic effect, Phytochemicals with Anticancer activity, Lycopene and isothiocyanate applications in papaya, papaya seed products and in vivo animal studies.’

Turbid Water Treatment Using Deshelled Carica papaya Seed: Analysis Via Factorial Design

Natural coagulants are proven to be a good alternative to conventional coagulants with the removal of various pollutants and are environmentally friendly. Despite its advantages, the least studies were carried out on local agro-wastes such as papaya seeds as natural coagulants concerning different operational factors. The study analyzes the main and interactions effect between the coagulant dosage, initial turbidity, and pH on deshelled Carica papaya seeds for turbid water treatment. A 2-level factorial design was used to investigate the main and interaction effects of the main operational factors, viz. coagulant dosage (50-200 mg/L), pH (3-7), and initial turbidity (100-500 NTU) on the turbidity removal of the synthetic turbid water. Based on individual performance, the results suggested that initial turbidity and pH are the most significant factors among the investigated operational factors. In combination, all interactions are significant, but the interaction between initial turbidity and pH is most significant, with 97.2% turbidity removal. Upon application of Carica papaya seed as a natural coagulant in water and wastewater treatment, these operating variables and their interactions are best to be considered.

Effect of Ethanolic Extract of Carica Papaya seeds in Drug-Induced Acute Nephrotoxicity

Background: Nephrotoxicity is characterized by raised serum urea and creatinine levels and kidneys being one of the primary organs of drug concentration and excretion are vulnerable to many widely used marketed drugs, including anti-cancer drugs, antibiotics, immunosuppressants, and radio contrast agents, are nephrotoxic. Aim: To determine the nephroprotective effect of ethanolic extract of Carica papaya seeds in Aminoglycoside induced acute nephrotoxicity. Study design: Quasi Experimental study. Methodology: Thirty Sprague Dawley rats were sub divided into 3 groups i.e., I, II and III with 10 rats in each group. Group II and III were administered Aminoglycoside drug; Gentamycin in 80 mg/kg) via intraperitoneal route once daily for 5 consecutive days to induce acute nephrotoxicity. At day 6, nephrotoxicity was confirmed by measuring serum urea and creatinine. Ethanolic extract of Carica papaya seeds (1000 mg/kg) was started once daily through oral route in group III for 5 consecutive days to see the nephroprotective effects of seed extract after causing acute kidney injury. All animals were given standard diet pellets manufactured at NIH. Results: Mean serum urea and creatinine for Group I (Control Group) at day 0 were 24.90 mg/dL ± 1.633 and .750 mg/dL ± .0619 respectively. Mean serum urea and creatinine for Group II (Disease Control Group) was 81.00 mg/dL ± 1.247 and 1.980mg/dL ± .0467 at day 6th. This suggested induction of nephrotoxicity by Gentamycin. Mean serum urea and creatinine for Group III (Ethanolic Extract Treated Group) at 11 day was 72.40mg/dL± .991 and 1.680 mg/dL± .0467 after 5 days treatment with ethanolic extract of Carica papaya seeds. Conclusion: We concluded that ethanolic extract of Carica papaya seeds has significant nephroprotective effects on Aminoglycoside induced acute nephrotoxicity in rats. Keywords: COVID-19, Vaccination, Awareness and Adverse Effects

Utilization of citrus microcarpa peels and papaya seeds as a natural coagulant for turbidity removal

Coagulation and flocculation are an essential component of both the treatment of drinking water and the treatment of wastewater. The coagulant is one of the materials or substances that is added to the water to remove, stabilizes and causes colloidal particles to settle. Chemical coagulants such as aluminum sulphate (alum), ferric chloride, and synthetic polymers are the most commonly used coagulants in the industry due to their efficacy in turbidity removal. However, the use of chemical-based coagulants has had some negative impacts on human health and the environment, such as Alzheimer’s disease, and has produced a high volume of toxic sludge. In order to reduce negative impacts, this led to the discovery of an alternative to the natural coagulant (plant-based) for drinking water treatment. The coagulant used in this study is a combination of fruit waste containing citrus microcarpa peels and papaya seed with a ratio of 80:20 and 40:60. In addition to determining the potential of the composite natural coagulant, the optimal dosage and the effect of the mixing duration are also studied in order to determine the best mixing duration for each stage of the coagulation-flocculation process. Laboratory-scale studies using jar test experiments were conducted on surface water to determine the percentage of turbidity removal. Fruit waste was collected from the UiTM Pulau Pinang cafeteria, dried in the oven for 24 hours at a temperature of 105°C. The optimum dosage of composite natural coagulant is 90 mg/L using an 80:20 ratio of citrus microcarpa peels and papaya seeds with 97% of turbidity removal. The optimum mixing time is determined where the fast mixing time is 180 rpm for 3 minutes, the slow mixing time is 20 minutes with 10 rpm and the settling time is 30 minutes. The study shows that citrus microcarpa peels and papaya seeds have the potential to become effective natural coagulants in the future.

Potential of papaya seeds as a heterogenous catalyst in biodiesel synthesis

A biomass based low-cost catalyst production has been attempted. This study evaluated papaya seeds as the catalyst precursor for biodiesel synthesis. Dried papaya seed powder was calcined at 500°C for 3 hours to produce papaya seed ash. Then, papaya seed ash was applied as catalyst for transesterification of palm oil and methanol. Catalyst load and reaction time was varied. Papaya seed ash was analyzed by SEM-EDX and biodiesel physical properties was analyzed according to the European standards (EN 14214). SEM-EDX results indicated that papaya seed ash contains a number of minerals such as K2O, MgO and CaO which can function as catalysts in biodiesel synthesis. The produced biodiesel also met European standards. Highest biodiesel yield of 95.6% was obtained for reaction temperature of 60°C, reaction time of 2 hours, catalyst load of 2%, methanol to oil ratio of 12:1. Preliminary research revealed that PSA may be applied as a catalyst in biodiesel synthesis.

Hepatoprotective Effect of Papaya Seed Ethanol Extract on Rifampicin Isoniazid-induced Rats

Aims: Hepatotoxicity induced by anti-tuberculosis drugs, including rifampicin and isoniazid (AT- DILI, Anti Tuberculosis-Drug Induced Liver Injury), is an adverse reaction followed by significant morbidity. Several in vivo and in vitro research has confirmed that papaya seeds contain various non-essentials, minerals, and fiber. Carica papaya role in disease prevention through modulation of various processes, such as anti-inflammatory, anti-diabetes, immunomodulatory activity, and antioxidant activity, suggests a role in neutralizing free radical generation and ultimately preventing pathogenesis. This study aimed to determine the hepatoprotective effect of ethanol extract of papaya seeds on rifampicin and isoniazid- induced rats. Study Design: This study is experimental study. Methodology: The experimental animals in this study were divided into eight groups, including normal group, negative group 1, negative group 2, negative group 3, positive group, treatment group I (papaya seed ethanol extract dose of 100 mg/kgBW), treatment group II (papaya seed ethanol extract dose of 300 mg/kgBW), and treatment group III (papaya seed ethanol extract dose of 500 mg/kgBW), then the rats were dissected, and blood was taken for AST, ALT, ALP, GGT, and Bilirubin level measurements. Results: The results showed that papaya seed ethanol extract could reduce ALT, AST, ALP, GGT, and Bilirubin levels that were significantly different (P <0.05) than those in the negative control group. Conclusion: Flavonoid contains in the extract ethanol carica papaya has vita role to prevent the liver toxicity caused by isoniazid and rifampicin.

Deshelled Carica papaya Seeds as Natural Coagulant for Improvement Quality of River Water

This study evaluated the efficiency of deshelled papaya seeds as the natural coagulant in improving quality of river water. The deshelled papaya seeds biomass was mainly characterized for functional groups using FTIR, surface charge and protein content. Coagulation and flocculation tests were conducted using batch test for various dosages and pH values. The optimum dosage and pH were then tested in treating river of Class III to Class V. The functional groups in deshelled papaya seeds were O-H, C=O and C-O groups. The surface charge and protein content was +0.4 meq/g and 363 mg/g, respectively. The deshelled papaya seeds coagulant was able to remove turbidity up to 87.6 and 88.3% for river of Class III and Class IV, respectively, as well as 57.6 and 62.1% of total coliform and escherichia coli, respectively, from Class III river at dosage 196 mg/L and pH 4. This study demonstrated that the deshelled Carica papaya seeds-derived coagulant is capable in treating common pollutants of river and simultaneously shows antibacterial properties.

Potential of Carica papaya Seed-Derived Bio-Coagulant to Remove Turbidity from Polluted Water Assessed through Experimental and Modeling-Based Study

It is important to develop renewable bio-coagulants to treat turbid water and efficient use of these bio-coagulants requires process optimization to achieve robustness. This study was conducted to optimize the coagulation process using bio-coagulant of deshelled Carica papaya seeds by employing response surface methodology (RSM). This bio-coagulant was extracted by a chemical-free solvent. The experiments were conducted using the Central Composite Design (CCD). Initially, the functional groups and protein content of the bio-coagulant were analyzed. The Fourier Transform Infrared Spectroscopy analysis showed that the bio-coagulant contained OH, C=O and C-O functional groups, which enabled the protein to become polyelectrolyte. The highest efficiency of the bio-coagulant was obtained at dosage of 196 mg/L, pH 4.0 and initial turbidity of 500 NTU. At the optimum conditions, the bio-coagulant achieved 88% turbidity removal with a corresponding 83% coagulation activity. These findings suggested that the deshelled Carica papaya seeds have potential as a promising bio-coagulant in treating the polluted water.