Calcium silicate-poly(n-butyl-2-cyanoacrylate) nanocomposite for bone tissue adhesion

2019 ◽  
Vol 110 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Rosa M. Guerra Bretaña ◽  
Lídia A. de Sena ◽  
Marilia S. Beltrão ◽  
Rodrigo F. Resende ◽  
Suelen C. Sartoretto ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Calcium Silicate ◽  
Tissue Adhesion

scholarly journals Therapeutic Effects of the Addition of Fibroblast Growth Factor-2 to Biodegradable Gelatin/Magnesium-Doped Calcium Silicate Hybrid 3D-Printed Scaffold with Enhanced Osteogenic Capabilities for Critical Bone Defect Restoration

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 712
Author(s):  
Wei-Yun Lai ◽  
Yen-Jen Chen ◽  
Alvin Kai-Xing Lee ◽  
Yen-Hong Lin ◽  
Yu-Wei Liu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Silicate ◽  
Clinical Applications ◽  
Fibroblast Growth Factor 2 ◽  
Therapeutic Effects ◽  
Fibroblast Growth ◽  
3D Printed

Worldwide, the number of bone fractures due to traumatic and accidental injuries is increasing exponentially. In fact, repairing critical large bone defects remains challenging due to a high risk of delayed union or even nonunion. Among the many bioceramics available for clinical use, calcium silicate-based (CS) bioceramics have gained popularity due to their good bioactivity and ability to stimulate cell behavior. In order to improve the shortcomings of 3D-printed ceramic scaffolds, which do not easily carry growth factors and do not provide good tissue regeneration effects, the aim of this study was to use a gelatin-coated 3D-printed magnesium-doped calcium silicate (MgCS) scaffold with genipin cross-linking for regulating degradation, improving mechanical properties, and enhancing osteogenesis behavior. In addition, we consider the effects of fibroblast growth factor-2 (FGF-2) loaded into an MgCS scaffold with and without gelatin coating. Furthermore, we cultured the human Wharton jelly-derived mesenchymal stem cells (WJMSC) on the scaffolds and observed the biocompatibility, alkaline phosphatase activity, and osteogenic-related markers. Finally, the in vivo performance was assessed using micro-CT and histological data that revealed that the hybrid bioscaffolds were able to further achieve more effective bone tissue regeneration than has been the case in the past. The above results demonstrated that this type of processing had great potential for future clinical applications and studies and can be used as a potential alternative for future bone tissue engineering research, as well as having good potential for clinical applications.

Review on calcium silicate‐based bioceramics in bone tissue engineering

2020 ◽  
Vol 17 (5) ◽  
pp. 2450-2464 ◽  
Author(s):  
Palakurthy Srinath ◽  
P. Abdul Azeem ◽  
K. Venugopal Reddy
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Silicate

scholarly journals Characterization and osteogenic evaluation of mesoporous magnesium–calcium silicate/polycaprolactone/polybutylene succinate composite scaffolds fabricated by rapid prototyping

RSC Advances ◽  
2018 ◽  
Vol 8 (59) ◽  
pp. 33882-33892 ◽  
Author(s):  
Yun Gyeong Kang ◽  
Jie Wei ◽  
Ji Eun Kim ◽  
Yan Ru Wu ◽  
Eun Jin Lee ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Rapid Prototyping ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Silicate ◽  
Composite Scaffold ◽  
Composite Scaffolds ◽  
Polybutylene Succinate

A new composite scaffold consisting of mesoporous magnesium–calcium silicate (m_MCS), polycaprolactone (PCL), and polybutylene succinate (PBSu) was manufactured by a rapid prototyping technique, for stem cell-based bone tissue engineering.

scholarly journals 3D-Printed Bioactive Calcium Silicate/Poly-ε-Caprolactone Bioscaffolds Modified with Biomimetic Extracellular Matrices for Bone Regeneration

2019 ◽  
Vol 20 (4) ◽  
pp. 942 ◽  
Author(s):  
Yuan-Haw Wu ◽  
Yung-Cheng Chiu ◽  
Yen-Hong Lin ◽  
Chia-Che Ho ◽  
Ming-You Shie ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Calcium Silicate ◽  
Interleukin 1 ◽  
Orthopedic Implants ◽  
Cellular Adhesion ◽  
Bone Tissue Regeneration ◽  
Necrosis Factor Alpha ◽  
Mg63 Cells ◽  
3D Printed

Currently, clinically available orthopedic implants are extremely biocompatible but they lack specific biological characteristics that allow for further interaction with surrounding tissues. The extracellular matrix (ECM)-coated scaffolds have received considerable interest for bone regeneration due to their ability in upregulating regenerative cellular behaviors. This study delves into the designing and fabrication of three-dimensional (3D)-printed scaffolds that were made out of calcium silicate (CS), polycaprolactone (PCL), and decellularized ECM (dECM) from MG63 cells, generating a promising bone tissue engineering strategy that revolves around the concept of enhancing osteogenesis by creating an osteoinductive microenvironment with osteogenesis-promoting dECM. We cultured MG63 on scaffolds to obtain a dECM-coated CS/PCL scaffold and further studied the biological performance of the dECM hybrid scaffolds. The results indicated that the dECM-coated CS/PCL scaffolds exhibited excellent biocompatibility and effectively enhanced cellular adhesion, proliferation, and differentiation of human Wharton’s Jelly mesenchymal stem cells by increasing the expression of osteogenic-related genes. They also presented anti-inflammatory characteristics by showing a decrease in the expression of tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1). Histological analysis of in vivo experiments presented excellent bone regenerative capabilities of the dECM-coated scaffold. Overall, our work presented a promising technique for producing bioscaffolds that can augment bone tissue regeneration in numerous aspects.

scholarly journals Laser Sintered Magnesium-Calcium Silicate/Poly-ε-Caprolactone Scaffold for Bone Tissue Engineering

Materials ◽  
2017 ◽  
Vol 10 (1) ◽  
pp. 65 ◽  
Author(s):  
Kuo-Yang Tsai ◽  
Hung-Yang Lin ◽  
Yi-Wen Chen ◽  
Cheng-Yao Lin ◽  
Tuan-Ti Hsu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Silicate

Fabrication, characterization, bioactivity, and biocompatibility of novel mesoporous calcium silicate/polyetheretherketone composites

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 57131-57137 ◽  
Author(s):  
G. F. Hu ◽  
R. F. Quan ◽  
Y. M. Chen ◽  
D. W. Bi ◽  
X. S. Jiang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Silicate ◽  
Bone Tissue Regeneration

Composite consisting of polyetheretherketone and mesoporous calcium silicate were fabricated. The composite with improved hydrophilicity, bioactivity and biocompatibility might be a great candidate for bone tissue regeneration.

Osteopontin sequence modified mesoporous calcium silicate scaffolds to promote angiogenesis in bone tissue regeneration

2020 ◽  
Vol 8 (27) ◽  
pp. 5849-5861
Author(s):  
Min Zhu ◽  
He He ◽  
Qingxi Meng ◽  
Yufang Zhu ◽  
Xiaojian Ye ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Silicate ◽  
Bone Tissue Regeneration ◽  
Surface Grafting

Surface grafting and encapsulation of SVVYGLR peptides in MCS promote vessel/bone formation all over the scaffold.

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