scholarly journals Hypoglycemic Effect of Tofu Refuse-Enriched Cake on Blood Glucose Level in Healthy Subjects and its Sensory Attributes

2008 ◽  
Vol 55 (8) ◽  
pp. 367-372 ◽  
Author(s):  
Yasuhiro Funatsu ◽  
Yukiko Nishimura ◽  
Makoto Ishioroshi ◽  
Kazuo Uebaba ◽  
Yukio Nishio ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Healthy Subjects ◽  
Sensory Attributes ◽  
Hypoglycemic Effect

scholarly journals Hypoglycemic Effect of Nigella sativa L. (Ranunculaceae) Extract in Streptozocin (STZ) Induced Diabetic Rats

2020 ◽  
Vol 8 (02) ◽  
pp. 35-39
Author(s):  
Laxmi Shrestha ◽  
Amit Shrivastava ◽  
Bishal Joshi ◽  
Buddhi Raj Pokhrel ◽  
Shanti Gurung ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Nigella Sativa ◽  
Negative Control ◽  
Hypoglycemic Effect ◽  
Control Group ◽  
Oral Glucose ◽  
Standard Group

INTRODUCTION Diabetes mellitus is the most common metabolic disease worldwide. Nigella sativa also known as black cumin, is an emerging miracle herb with a rich historical and religious background. In the present study, we have attempted to study the hypoglycemic effect of aqueous extract of Nigella sativa on diabetes-induced rats. MATERIAL AND METHODS This preclinical study was conducted in Department of Pharmacology from August to October 2019. In this study, hyperglycemia was induced by a single intraperitoneal dose of 60 mg/kg streptozotocin in 0.1 M citrate buffer (pH 4.5). Animals were divided into five groups containing normal control, negative control, standard, test-1, and test-2. The aqueous extract of Nigella sativa was administered 400 and 800 mg/kg per oral in both the test groups for 18 days. Blood glucose level was measured at three-days interval by glucometer. Oral glucose tolerance test was done by administrating 2 gm/kg per oral glucose and the blood glucose was recorded every two-hours interval for eight hours. RESULTS An oral glucose tolerance test showed a decrease in blood glucose level at the dose of 400 and 800 mg/kg compared to the negative control group. The administration of aqueous extract of Nigella sativa for 18 days showed significant decrease in blood glucose level (p=0.001) compared to negative control group. The blood glucose level in test 1 (400 mg/kg) was significantly reduced compared to the standard group (p***<0.001). The blood glucose level in test 2 at 18th day was less significant (p*< 0.05) compared with standard group and test 1 (p**<0.01, p***<0.001). CONCLUSION The findings of the present study indicate that the aqueous extract of Nigella sativa has significant hypoglycemic effect in Wistar rats.

scholarly journals Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Roderic John R. Magtulis ◽  
Emvie Loyd P. Itable, RN, MAN
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Alloxan Monohydrate

<p class="AbstractContent"><strong>Objective:</strong> Diabetes Mellitus is a leading illness to the society and despite of a lot of researches, not a single cure has been discovered. Most of the time, people focused on fighting diabetes and medicinal plants were utilized. The purpose of this study was to investigate the hypoglycemic effect of Scarlet Spiral Flag (<em>Costus woodsonii</em>) and to be reviewed for preclinical trials.</p><p class="AbstractContent"><strong>Methods: </strong>20 male Swiss mice were made diabetic by inducing Alloxan monohydrate. Then separated randomly into 4 groups with different treatments administered daily for 7 days; Control, Positive Control (600 µg/kg Glibenclamide), T1 (250mg/kg Scarlet Spiral Flag ethanolic extract) and T2 (500mg/kg Scarlet Spiral Flag ethanolic extract). Their blood sugar was monitored onset after 1<sup>st</sup> treatment (6<sup>th</sup>, 12<sup>th</sup> and 24<sup>th</sup> hours) and during the week within the 1<sup>st</sup>, 4<sup>th</sup> and 8<sup>th</sup> day.</p><p class="AbstractContent"><strong>Results:</strong> Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice.<strong></strong></p><p class="AbstractContent"><strong>Conclusion: </strong>The ethanolic extract of Scarlet Spiral Flag (<em>Costus woodsonii</em>) has a potent antidiabetic effect in Alloxan-induced diabetic mice. Since it is under the same Genus of the Insulin plant, it has a common effect in terms of lowering the blood glucose level.</p><p class="AbstractContent"><strong>Keywords: </strong>Acclimatization, Alloxan, <em>Costus woodsonii, </em>Ethanolic Extract, Oral Gavage</p>

The Relationship Between Periodontal Disease And Blood Glucose Level Among Type II Diabetic Patients

2001 ◽  
Vol 2 (4) ◽  
pp. 1-6 ◽  
Author(s):  
Khalid Almas ◽  
Mohammed Al-Qahtani ◽  
Marzouk Al-Yami ◽  
Nazeer Khan
Keyword(s):  
Blood Glucose ◽  
Periodontal Disease ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Oral Hygiene ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Type Ii ◽  
Hygiene Practices ◽  
The Relationship

Abstract The aim of this study was to determine the relationship between periodontal disease and the blood glucose level among type II non-insulin dependent diabetic mellitus (NIDDM) subjects. Forty subjects, 20 in each group, of healthy and diabetic subjects, ages ranged 20-70 years, were examined at King Saud University, College of Dentistry. Clinical examination included frequency of oral hygiene practices, periodontal status by using the Community Periodontal Index of Treatment Needs (CPITN), fasting blood glucose level (FBGL), and random blood glucose level (RBGL). Unstandardized orthopantomograms (OPGs) were taken for radiographic findings. The number of missing teeth (tooth loss) was assessed from the radiographs. The results showed that periodontal disease severity was high among diabetic subjects. Diabetic subjects brushed less frequently, and they had a higher blood glucose level than healthy subjects. The mean CPITN score was compared with mean blood glucose level and the severity of periodontal disease. There was a steady increase in blood glucose level with increase in CPITN scores, i.e., CPITN score 13.5 to 19.12 corresponded with 142 mg/dl and 173.2 mg/dl FBGL, and 184.2 and 199.12 mg/dl RBGL among diabetic subjects. The study indicated that diabetic subjects should improve their oral hygiene practices and control of blood glucose levels should be emphasized. Further studies are needed among diabetics and healthy subjects from the general population with better sampling techniques and a larger sample size. Citation Almas K, Al-Qahtani M, Al-Yami M, Khan N. The Relationship Between Periodontal Disease And Blood Glucose Level Among Type II Diabetic Patients. J Contemp Dent Pract 2001 Nov;(2)4: 018-025.

scholarly journals Hypoglycemic Effect of Glechoma hederacea Extract on Blood Glucose Level in Rats

2007 ◽  
Vol 54 (9) ◽  
pp. 412-414 ◽  
Author(s):  
Shinji Ishihara ◽  
Ayumi Kawata ◽  
Miho Inoue ◽  
Toshiro Watanabe ◽  
Keisuke Tsuji
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Hypoglycemic Effect ◽  
Glechoma Hederacea

scholarly journals Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats

2020 ◽  
Vol 11 (4) ◽  
pp. 759-764
Author(s):  
Murtaza Haidari ◽  
Kawsar Alami ◽  
Arefa Hossaini ◽  
Sayed Yousof Mousavi
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Body Weight Loss ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hibiscus Sabdariffa ◽  
Carum Carvi

Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of H. sabdariffa (75, 150 and 300 mg/kg), C. carvi (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21st days. The results showed a significant (P<0.0001) hypoglycemic effect of H. sabdariffa extract (75, 150 and 300 mg/kg) on 7, 14 and 21th days, C. carvi extract (500 mg/kg), and their effective doses combination (75:25), especially on 7th day. Only 75 mg/kg of H. sabdariffa had positive effect on body weight loss of diabetic rats (P<0.05). One can conclude that Afghan H. sabdariffa and C. carvi hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of H. sabdariffa was much greater and even normalized the blood glucose level.

scholarly journals Experimental study of hypoglycemic effect of medicago sativa leaves extract

2014 ◽  
Vol 95 (4) ◽  
pp. 557-561
Author(s):  
R F Eremenko ◽  
L N Maloshtan ◽  
E Yu Yatsenko
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Medicago Sativa ◽  
Glucose Level ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Glucose Load ◽  
Second Stage ◽  
Intact Rats

Aim. To study the hypoglycemic effect of the Medicago Sativa leaves extract in intact rats and in rats with a glucose load. Methods. At the first stage, hypoglycemic effect of Medicago Sativa leaves extract was determined in intact rats. 50 mg/kg of metformin and 18 mg/kg of herbal anti-diabetic «Arfazetin» tea were used as comparator drugs. At the second stage, hypoglycemic effect of Medicago Sativa leaves extract was determined in rats with glucose load. Blood samples for glucose analysis were taken before and in 15, 30, 60 and 120 minutes after loading. Blood glucose level was determined by glucose oxidase method. Results. Medicago Sativa leaves extract showed hypoglycemic effect both in intact animals and in animals with glucose load. 25 mg/kg of Medicago Sativa leaves extract decreased blood glucose level in intact animals at 4, 6 and 8 hours by 1.04, 1.14 and 1.11 times compared to the baseline level; the effect was comparable with herbal anti-diabetic «Arfazetin» tea and was inferior to metformin. A single 25 mg/kg dose of Medicago Sativa leaves extract showed hypoglycemic effect in animals with glucose load and significantly reduced blood glucose level in 15, 30, 60 and 120 minutes compared to control. Conclusion. The findings suggest that 25 mg/kg of Medicago Sativa leaves extract can be used as a herbal medication in the complex treatment of type II diabetes mellitus for its hypoglycemic properties.

scholarly journals EVALUATION OF ANTI-DIABETIC ACTIVITY OF FICUS BENGALENSIS LINN IN ALLOXAN INDUCED RATS

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fegade Sachin A ◽  
Siddaiah M
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Ficus Bengalensis

The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Ficus bengalensis in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug extract in 150 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated fractions produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly. Keywords: Ficus begalensis, antidiabetic, allaxon induced, Diabetes mellitus.

Evalution of anti Diabetic Activity for ethanolic extract Syzygium cumini leaf in Alloxan induced diabetic rat

2015 ◽  
Vol 1 (1) ◽  
pp. 27-31
Author(s):  
Maheswararao Chattu ◽  
Guptha Attyam
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hypoglycemic Agents ◽  
Syzygium Cumini ◽  
Test Drug ◽  
Standard Drug

The available drugs for the treatment of diabetes, such as Insulin or Oral hypoglycemic agents have one or more side effects. So the search for newer anti-diabetic drugs with minimum or no side effects from herbal plants is a challenge as per world health organization (WHO) recommendations. Diabetes mellitus is a metabolic disorder of carbohydrate, protein and fat which are characterized by hyperglycemia, polyuria, polydipsia, and polyphagia which is deficient insulin production or ineffectiveness in insulin actions. The present study was aimed to evaluate the anti diabetic potency of syzygium cumini leaf on the blood glucose level in alloxan induced diabetic rats. Diabetic Wistar strain rats were treated with standard drug Glibenclamide and test drug syzygium cumini at 100mg, 200mg. The hypoglycemic effect was determined in the rats and the efficacy of the test drug was compared to the standard drug Glibenclamide. Syzygium cumini leaf was orally administered for 14 days in alloxan induced diabetic rats. At the end of the study duration blood glucose level and Biochemical parameters were statistically analyzed. Based on these results of the study this syzygium cumini produced a significant reduction in blood glucose levels when compared with diabetic control rats and hence the present research work proved that the syzygium cumini possess hypoglycemic effect.

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