scholarly journals The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects

Diabetologia ◽  
1969 ◽  
Vol 5 (5) ◽  
pp. 343-348 ◽  
Author(s):  
E. Cerasi ◽  
I. Chowers ◽  
R. Luft ◽  
A. Widstr�m
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Healthy Subjects ◽  
Plasma Insulin ◽  
Insulin Response ◽  
Plasma Insulin Response

Significance of genetic factors for the plasma insulin response to glucose in healthy subjects

2008 ◽  
Vol 10 (3) ◽  
pp. 125-134 ◽  
Author(s):  
Jan Lindsten ◽  
Erol Cerasi ◽  
Rolf Luft ◽  
Newton Morton ◽  
Nils Ryman
Keyword(s):  
Healthy Subjects ◽  
Plasma Insulin ◽  
Genetic Factors ◽  
Insulin Response ◽  
Insulin Response To Glucose ◽  
Plasma Insulin Response

Action of Insulin on Distribution of Glucose Analogs in Eviscerated-Nephrectomized Dogs

1958 ◽  
Vol 193 (3) ◽  
pp. 461-465 ◽  
Author(s):  
Bernard R. Landau ◽  
Arthur G. Ship ◽  
Herbert J. Levine
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Insulin Response ◽  
Hydroxyl Group ◽  
Functional Nature ◽  
Specific Configuration ◽  
Insulin Responsiveness

Insulin increased the distribution of 2-deoxyglucose, 3-deoxyglucose and 2-deoxygalactose in eviscerated-nephrectomized dogs. 6-O-methylglucose was nonresponsive to insulin. The response of 3-O-methylglucose appeared dependent upon the blood glucose level. These results are interpreted as indicating that the stereochemical requirements of aldohexoses for insulin response does not require a hydroxyl group on either carbon 2 or 3 of the molecule, nor does it require a specific configuration of the hydroxyl on carbon 4. It is suggested from the behavior of the methylated analogs that the size rather than the functional nature of the group at carbons 3 and 6 is important in determining insulin responsiveness.

The Relationship Between Periodontal Disease And Blood Glucose Level Among Type II Diabetic Patients

2001 ◽  
Vol 2 (4) ◽  
pp. 1-6 ◽  
Author(s):  
Khalid Almas ◽  
Mohammed Al-Qahtani ◽  
Marzouk Al-Yami ◽  
Nazeer Khan
Keyword(s):  
Blood Glucose ◽  
Periodontal Disease ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Oral Hygiene ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Type Ii ◽  
Hygiene Practices ◽  
The Relationship

Abstract The aim of this study was to determine the relationship between periodontal disease and the blood glucose level among type II non-insulin dependent diabetic mellitus (NIDDM) subjects. Forty subjects, 20 in each group, of healthy and diabetic subjects, ages ranged 20-70 years, were examined at King Saud University, College of Dentistry. Clinical examination included frequency of oral hygiene practices, periodontal status by using the Community Periodontal Index of Treatment Needs (CPITN), fasting blood glucose level (FBGL), and random blood glucose level (RBGL). Unstandardized orthopantomograms (OPGs) were taken for radiographic findings. The number of missing teeth (tooth loss) was assessed from the radiographs. The results showed that periodontal disease severity was high among diabetic subjects. Diabetic subjects brushed less frequently, and they had a higher blood glucose level than healthy subjects. The mean CPITN score was compared with mean blood glucose level and the severity of periodontal disease. There was a steady increase in blood glucose level with increase in CPITN scores, i.e., CPITN score 13.5 to 19.12 corresponded with 142 mg/dl and 173.2 mg/dl FBGL, and 184.2 and 199.12 mg/dl RBGL among diabetic subjects. The study indicated that diabetic subjects should improve their oral hygiene practices and control of blood glucose levels should be emphasized. Further studies are needed among diabetics and healthy subjects from the general population with better sampling techniques and a larger sample size. Citation Almas K, Al-Qahtani M, Al-Yami M, Khan N. The Relationship Between Periodontal Disease And Blood Glucose Level Among Type II Diabetic Patients. J Contemp Dent Pract 2001 Nov;(2)4: 018-025.

BLOOD GLUCOSE LEVEL IN MICE

1967 ◽  
Vol 56 (4) ◽  
pp. 713-725 ◽  
Author(s):  
Ingmar Lundquist ◽  
Claus Rerup
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Pancreatic Beta Cells ◽  
Plasma Insulin ◽  
Alloxan Diabetes ◽  
Physiological Significance ◽  
Measurable Effect ◽  
Hypoglycaemic Effect ◽  
Plasma Insulin Levels

ABSTRACT The hypoglycaemic effect of synthetic tetraicosapeptide corticotrophin was investigated in NMRI mice in order to determine its physiological significance as well as its mechanism of action. It was found that in normal non-fasting mice corticotrophin produced a maximal hypoglycaemic response at a dose level of about 5 μg per 20 g mouse (1250 milliunits per 20 g mouse). The ED50 of the hypoglycaemic effect was about 1000 times larger than the ED50 for adrenal cortical stimulation. Immunoassayable insulin was markedly increased 15 minutes following 5 μg of corticotrophin, whereas following a maximal steroidogenic dose (1.6 nanogram) or following ether stress the plasma insulin levels were normal. In adrenalectomized mice the administration of 5 μg of corticotrophin had practically no effect on the blood glucose level, whereas pretreatment with a glucocorticosteroid in adrenalectomized mice markedly restored the hypoglycaemic response. Acutely hypophysectomized mice showed a hypoglycaemic response to corticotrophin indistinguishable from that found in normal mice, whereas animals hypophysectomized 3–7 days before corticotrophin injection showed a smaller response. Corticotrophin in a dose of 5 μg per 20 g mouse had no hypoglycaemic effect in mice with manifest alloxan diabetes. Corticotrophin injected 5 minutes following a diabetogenic dose of alloxan hardly had any measurable effect on the acute initial alloxan hyperglycaemia, whereas the latter was greatly reduced when corticotrophin was given 5 minutes before alloxan administration. Pretreatment with corticotrophin did not change the frequency or intensity of the ensuing diabetic condition in mice. It is concluded that the corticotrophin induced hypoglycaemia is dependent on 1) the presence of normally functioning pancreatic beta-cells; and 2) the presence of glucocorticosteroids. It is doubtful whether the observed hypoglycaemia has any physiological significance.

scholarly journals Hypoglycemic Effect of Tofu Refuse-Enriched Cake on Blood Glucose Level in Healthy Subjects and its Sensory Attributes

2008 ◽  
Vol 55 (8) ◽  
pp. 367-372 ◽  
Author(s):  
Yasuhiro Funatsu ◽  
Yukiko Nishimura ◽  
Makoto Ishioroshi ◽  
Kazuo Uebaba ◽  
Yukio Nishio ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Healthy Subjects ◽  
Sensory Attributes ◽  
Hypoglycemic Effect

scholarly journals Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Huda Mohammed Alkreathy ◽  
Aftab Ahmad
Keyword(s):  
Antioxidant Enzymes ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Plasma Insulin ◽  
Glycogen Storage ◽  
Control Group ◽  
Group 5 ◽  
Group 2 ◽  
Control Group Group

Catharanthus roseus (C. roseus) and ursolic acid (UA) are ayurvedic medicines with multiple pharmacological activities including antidiabetic activity, but till date, no study is available on their combination. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. Rats were divided into six groups. All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. Group 1 was treated as a normal control (NC) group and fed with saline water, Group 2 as a Diabetes Control group, Group 3 as a STZ+C. roseus ethanolic extract (CREE) group at 50 mg/kg p.o., Group 4 as a STZ+UA group orally at 50 mg/kg, Group 5 as a STZ+CREE (25 mg/kg p.o.)+UA (25 mg/kg p.o.) group, and Group 6 as a STZ+Glimepiride (0.1 mg/kg) group. Diabetes was confirmed after 72 hours by estimation of blood glucose level, and then treatment was given for the next 28 days. During the course of treatment, plasma insulin and blood glucose were measured regularly at the interval of 7 days. At the end of the protocol, blood was collected and animals were sacrificed. The glucose level, insulin level, liver glycogen storage level, and antioxidant enzymes (LPO, CAT, SOD, GPx, GST) were measured. The blood glucose level in Group 5 significantly (P<0.001) reduced to 98.35±2.45 mg/dl in comparison with that in Group 2 (321.75±5.46 mg/dl). The level of plasma insulin in Group 5 increased (13.65±0.10 μU/ml) significantly (P<0.01) as compared with that in Group 2 (05.93±0.31 μU/ml). In Group 5, the level of glycogen in liver was significantly (P<0.01) increased as compared with that in Group 2 rats. The level of antioxidant enzymes in Group 5 restored toward normal values significantly (P<0.01; P<0.001) as compared with that in Group 2 animals. These findings suggest that low-dose combination of CREE and UA is effective in the treatment of diabetes.

Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats

1990 ◽  
Vol 126 (3) ◽  
pp. 451-459 ◽  
Author(s):  
H. Sakurai ◽  
K. Tsuchiya ◽  
M. Nukatsuka ◽  
M. Sofue ◽  
J. Kawada
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Plasma Insulin ◽  
Active Form ◽  
Insulin Level ◽  
Plasma Insulin Level ◽  
High Concentration ◽  
Vanadyl Ion ◽  
Vanadyl Sulphate

ABSTRACT Recent studies have indicated that the blood glucose level of rats with streptozotocin (STZ)-induced diabetes (type 1) is normalized without an increase in the plasma insulin level by administration of sodium orthovanadate in the drinking water. The mechanism of this insulin-like effect of vanadate is unknown. In this study, we investigated whether vanadyl ion, which is less toxic than vanadate to rats, also has an insulin-like effect in rats with STZ-induced diabetes. When rats with STZ-induced diabetes were given a daily i.p. injection of vanadyl sulphate (9·3 and 4·6 mg vanadium/kg body weight), their blood glucose level decreased from about 22·2 to about 7·2 mmol glucose/l within 2 days and remained low for at least 12 weeks. This treatment did not affect their low plasma insulin level. Quantitative electron spin resonance (ESR) spectrometry showed that most of the vanadium (about 90%) in their tissues was present as a vanadyl form (VO2+). ESR analysis also showed that the vanadyl ion in tissues was bound endogenously with four oxygen ligands from either water or oxyamino acid residues in proteins. Vanadyl sulphate accelerated glucose incorporation into adipocytes of rats, suggesting that the action of vanadyl ion is peripheral. Interestingly, vanadyl sulphate at a high concentration (about 10 mmol/l) was more effective than insulin in enhancing glucose uptake. This study demonstrated that: (1) vanadyl sulphate (+ 4 oxidation state), like vanadate ion, normalizes the blood glucose levels of rats with STZ-induced diabetes; (2) the action of vanadyl ion is peripheral; and (3) the active form of vanadium for an insulin-like effect may be a vanadyl form, not vanadate. Journal of Endocrinology (1990) 126, 451–459

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