scholarly journals Experimental study of hypoglycemic effect of medicago sativa leaves extract

2014 ◽  
Vol 95 (4) ◽  
pp. 557-561
Author(s):  
R F Eremenko ◽  
L N Maloshtan ◽  
E Yu Yatsenko
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Medicago Sativa ◽  
Glucose Level ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Glucose Load ◽  
Second Stage ◽  
Intact Rats

Aim. To study the hypoglycemic effect of the Medicago Sativa leaves extract in intact rats and in rats with a glucose load. Methods. At the first stage, hypoglycemic effect of Medicago Sativa leaves extract was determined in intact rats. 50 mg/kg of metformin and 18 mg/kg of herbal anti-diabetic «Arfazetin» tea were used as comparator drugs. At the second stage, hypoglycemic effect of Medicago Sativa leaves extract was determined in rats with glucose load. Blood samples for glucose analysis were taken before and in 15, 30, 60 and 120 minutes after loading. Blood glucose level was determined by glucose oxidase method. Results. Medicago Sativa leaves extract showed hypoglycemic effect both in intact animals and in animals with glucose load. 25 mg/kg of Medicago Sativa leaves extract decreased blood glucose level in intact animals at 4, 6 and 8 hours by 1.04, 1.14 and 1.11 times compared to the baseline level; the effect was comparable with herbal anti-diabetic «Arfazetin» tea and was inferior to metformin. A single 25 mg/kg dose of Medicago Sativa leaves extract showed hypoglycemic effect in animals with glucose load and significantly reduced blood glucose level in 15, 30, 60 and 120 minutes compared to control. Conclusion. The findings suggest that 25 mg/kg of Medicago Sativa leaves extract can be used as a herbal medication in the complex treatment of type II diabetes mellitus for its hypoglycemic properties.

Nanotechnology Mediated Diagnosis of Type II Diabetes Mellitus

2021 ◽  
Vol 14 ◽  
Author(s):  
Anjali Rajora ◽  
Kalpana Nagpal
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type Ii Diabetes ◽  
Glucose Sensor ◽  
Metabolic Diseases ◽  
Type Ii Diabetes Mellitus ◽  
The Body ◽  
Type Ii ◽  
Diagnostic Strategies

Abstract:: The metabolic diseases are the consequences of abnormal chemical reactions in the body leading to variation in the normal metabolic processes. These diseases have actually reached to an epidemic stage round the globe. Among the several types of metabolic disorders, type II diabetes is quite serious and dependent on glucose level in blood. The major challenge is the continuous monitoring of blood glucose level. Among the different blood sugar level diagnostic strategies, nanotechnology may offer several advantages over traditional systems owing to the better surface area of sensors, improved catalytic property of electrodes plus better handling. For this, reason, different types of nanosensors (to measure blood glucose level) and nanomaterials (to improve glucose sensor function) have been investigated by various researchers. This work is an effort to discuss the role of nanosensors and the major advancements that has been utilized so far for the effective and reproducible diagnosis of blood glucose level which may provide better and effective diagnosis for type 2 diabetes.

scholarly journals Increased Depression Affects Hyperglycemia Status in Type II Diabetes Mellitus Patients

2019 ◽  
Vol 2 (3) ◽  
pp. 121
Author(s):  
Dwi Nur Aini ◽  
Menik Kustriyani ◽  
Arifianto Arifianto
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type Ii Diabetes ◽  
Pearson Correlation ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Cross Sectional ◽  
Diabetes Mellitus Type Ii

Diabetes mellitus is a collection of symptoms that arise in a person caused by an increase in blood glucose levels. Chronic diseases such as type II diabetes mellitus can affect their psychological condition, namely depression. From the preliminary results the researchers compared 5 patients with type II diabetes mellitus in the Mijen health center area, 1 of them experienced fatigue, 4 of them experienced insomnia, were not productive, tired quickly when activity and appetite decreased. The purpose of the study was to determine the relationship between the level of depression with blood sugar levels in patients with type II diabetes mellitus. This type of research uses quantitative non-experiment with cross sectional design. Sampling with purposive sampling technique. Data were collected through questionnaires, analyzed using Sperman rank statistical test with a significant limit of 0.05. In this research shows pearson correlation coefficient rate of 0,524 and ρ =0,000. It show the  significant positive correlation between depression and blood glucose level on diabetic type II patient with the medium corelation level. The results showed that there was a relation between depression with blood glucose  level in diabetes mellitus type II patients. 

scholarly journals EFFECTIVENESS OF AMLA JUICE IN REDUCING BLOOD GLUCOSE LEVEL AMONG PATIENTS WITH TYPE II DIABETES IN A SELECTED AREA OF KANYAKUMARI DISTRICT

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mrs. Vanitha. S s ◽  
Dr. Pramjit kaur
Keyword(s):  
Blood Glucose ◽  
Standard Deviation ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type Ii Diabetes ◽  
Control Group ◽  
Type Ii ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Experimental Group

Challenges in lifestyle, such as increasesin energy intake and decreasesin physical activity are causing overweight and obesity leading to epidemic increases in type II Diabetes Mellitus. The research approach used for this study was evaluative approach and the research design was true experimental design. 60 patients with type II diabetes, 30 in experimental group and 30 in control group were selected for this study by using purposive sampling technique. Data was collected with the help of self-structured interview schedule. Descriptive statistics (frequency, percentage, mean and standard deviation) and inferential statistics (chi-square, paired ‘t’ test) were used to analyse the data and to test the hypotheses. In the experimental group,the pre-test mean score was 2.966, mean percentage was 59% and standard deviation was 1.129 and in post-testmean score was 2.533, mean percentage was 50.66% and standard deviation was 1.074 with effectiveness of 8.34% and paired‘t’ test value of t=3.971,which was statistically significant (p<0.05) which is an evidence ofthe effectiveness of Amla juice in reducing blood glucose level. Comparison of blood glucose levels in experimental and control groups, shows that the value is statistically highly significant, as was observed from the unpaired ‘t’ test value of 13.39 with P value of <0.05, which is an evidence indicatingthe effect of Amla juice in reducing postprandial blood glucose levels. The resultsfound that the administration of Amla juice did have aneffect in reducing blood glucose level in the experimental group. By comparing the findings of pre-test and post test between the experimental group and the control group,the effect was identified (assessed). The study concluded that the Amlajuice is effective in reducing blood glucose level.

scholarly journals Hypoglycemic Effect of Nigella sativa L. (Ranunculaceae) Extract in Streptozocin (STZ) Induced Diabetic Rats

2020 ◽  
Vol 8 (02) ◽  
pp. 35-39
Author(s):  
Laxmi Shrestha ◽  
Amit Shrivastava ◽  
Bishal Joshi ◽  
Buddhi Raj Pokhrel ◽  
Shanti Gurung ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Nigella Sativa ◽  
Negative Control ◽  
Hypoglycemic Effect ◽  
Control Group ◽  
Oral Glucose ◽  
Standard Group

INTRODUCTION Diabetes mellitus is the most common metabolic disease worldwide. Nigella sativa also known as black cumin, is an emerging miracle herb with a rich historical and religious background. In the present study, we have attempted to study the hypoglycemic effect of aqueous extract of Nigella sativa on diabetes-induced rats. MATERIAL AND METHODS This preclinical study was conducted in Department of Pharmacology from August to October 2019. In this study, hyperglycemia was induced by a single intraperitoneal dose of 60 mg/kg streptozotocin in 0.1 M citrate buffer (pH 4.5). Animals were divided into five groups containing normal control, negative control, standard, test-1, and test-2. The aqueous extract of Nigella sativa was administered 400 and 800 mg/kg per oral in both the test groups for 18 days. Blood glucose level was measured at three-days interval by glucometer. Oral glucose tolerance test was done by administrating 2 gm/kg per oral glucose and the blood glucose was recorded every two-hours interval for eight hours. RESULTS An oral glucose tolerance test showed a decrease in blood glucose level at the dose of 400 and 800 mg/kg compared to the negative control group. The administration of aqueous extract of Nigella sativa for 18 days showed significant decrease in blood glucose level (p=0.001) compared to negative control group. The blood glucose level in test 1 (400 mg/kg) was significantly reduced compared to the standard group (p***<0.001). The blood glucose level in test 2 at 18th day was less significant (p*< 0.05) compared with standard group and test 1 (p**<0.01, p***<0.001). CONCLUSION The findings of the present study indicate that the aqueous extract of Nigella sativa has significant hypoglycemic effect in Wistar rats.

scholarly journals Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Roderic John R. Magtulis ◽  
Emvie Loyd P. Itable, RN, MAN
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Alloxan Monohydrate

<p class="AbstractContent"><strong>Objective:</strong> Diabetes Mellitus is a leading illness to the society and despite of a lot of researches, not a single cure has been discovered. Most of the time, people focused on fighting diabetes and medicinal plants were utilized. The purpose of this study was to investigate the hypoglycemic effect of Scarlet Spiral Flag (<em>Costus woodsonii</em>) and to be reviewed for preclinical trials.</p><p class="AbstractContent"><strong>Methods: </strong>20 male Swiss mice were made diabetic by inducing Alloxan monohydrate. Then separated randomly into 4 groups with different treatments administered daily for 7 days; Control, Positive Control (600 µg/kg Glibenclamide), T1 (250mg/kg Scarlet Spiral Flag ethanolic extract) and T2 (500mg/kg Scarlet Spiral Flag ethanolic extract). Their blood sugar was monitored onset after 1<sup>st</sup> treatment (6<sup>th</sup>, 12<sup>th</sup> and 24<sup>th</sup> hours) and during the week within the 1<sup>st</sup>, 4<sup>th</sup> and 8<sup>th</sup> day.</p><p class="AbstractContent"><strong>Results:</strong> Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice.<strong></strong></p><p class="AbstractContent"><strong>Conclusion: </strong>The ethanolic extract of Scarlet Spiral Flag (<em>Costus woodsonii</em>) has a potent antidiabetic effect in Alloxan-induced diabetic mice. Since it is under the same Genus of the Insulin plant, it has a common effect in terms of lowering the blood glucose level.</p><p class="AbstractContent"><strong>Keywords: </strong>Acclimatization, Alloxan, <em>Costus woodsonii, </em>Ethanolic Extract, Oral Gavage</p>

scholarly journals Hypoglycemic Effect of Glechoma hederacea Extract on Blood Glucose Level in Rats

2007 ◽  
Vol 54 (9) ◽  
pp. 412-414 ◽  
Author(s):  
Shinji Ishihara ◽  
Ayumi Kawata ◽  
Miho Inoue ◽  
Toshiro Watanabe ◽  
Keisuke Tsuji
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Hypoglycemic Effect ◽  
Glechoma Hederacea
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