scholarly journals Design and implementation of a low-cost portable Raman spectrometer

2019 ◽  
Vol 65 (3) ◽  
pp. 274
Author(s):  
F. S. Chiwo ◽  
And F.J. Gonzalez
Keyword(s):  
Raman Spectroscopy ◽  
Diffuse Reflectance Spectroscopy ◽  
Low Cost ◽  
Optical Biopsy ◽  
Medical Community ◽  
High Price ◽  
Raman Spectrometer ◽  
Non Invasive ◽  
Optical Configuration

Non-invasive medical diagnosis has become popular due to the possibility of detecting illnesses in vivo and in real time this technique, often referred to as "optical biopsy", comprises several optical techniques such as thermography, diffuse reflectance spectroscopy, optical coherence tomography and Raman spectroscopy among others. Particularly Raman spectroscopy is an optical technique based on the inelastic scattering of light that can detect disease markers, this technique has been successfully used to detect several types of diseases, however the high price of a Raman spectrometer makes it difficult for the medical community to adopt its use as a common diagnostic procedure. In this work a Raman spectroscopy system was designed and fabricated from low-cost readily available components. The system was characterized and the Raman spectra obtained was compared to commercial systems. Results show that it is possible to fabricate a custom Raman system with the desired optical configuration for non-invasive optical diagnosis at low costs and portable size.

Non-invasive analysis of hormonal variations and effect of postmenopausal Vagifem treatment on women using in vivo high wavenumber confocal Raman spectroscopy

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

MEMS as In-Vivo Sensors and Actuators: Challenges and Opportunities

2000 ◽  
Author(s):  
Roop L. Mahajan
Keyword(s):  
Microelectromechanical Systems ◽  
Low Cost ◽  
High Volume ◽  
Medical Community ◽  
Medical Systems ◽  
Sensors And Actuators ◽  
Micro Fabrication ◽  
Challenges And Opportunities ◽  
Exceptional Stability

Abstract MicroElectroMechanical Systems (MEMS) is a developing field which promises to open up new fields of applications in such diverse areas as medical systems, wireless communications and space explorations. They are particularly attractive to the medical community for their consistent reproducibility, high levels of accuracy and reliability, and exceptional stability. This is achieved through silicon micro-fabrication techniques conducive to high volume manufacturing at a low cost.

scholarly journals Confocal Raman spectroscopy: Evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo

2019 ◽  
Vol 570 ◽  
pp. 118641 ◽  
Author(s):  
Christian J.F. Bertens ◽  
Shuo Zhang ◽  
Roel J. Erckens ◽  
Frank J.H.M. van den Biggelaar ◽  
Tos T.J.M. Berendschot ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Invasive Technique ◽  
Ketorolac Tromethamine ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals Non-invasive In Vivo Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS)

Theranostics ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 5899-5913 ◽  
Author(s):  
Fay Nicolson ◽  
Bohdan Andreiuk ◽  
Chrysafis Andreou ◽  
Hsiao-Ting Hsu ◽  
Scott Rudder ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
In Vivo Imaging ◽  
Non Invasive ◽  
Surface Enhanced

scholarly journals Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model

The Analyst ◽  
2010 ◽  
Vol 135 (12) ◽  
pp. 3142 ◽  
Author(s):  
Paul I. Okagbare ◽  
Francis W. L. Esmonde-White ◽  
Steven A. Goldstein ◽  
Michael D. Morris
Keyword(s):  
Raman Spectroscopy ◽  
Bone Graft ◽  
Rat Model ◽  
In Vivo Evaluation ◽  
Non Invasive

scholarly journals Detection of Age-Related Changes in Tendon Molecular Composition by Raman Spectroscopy—Potential for Rapid, Non-Invasive Assessment of Susceptibility to Injury

2020 ◽  
Vol 21 (6) ◽  
pp. 2150
Author(s):  
Nai-Hao Yin ◽  
Anthony W. Parker ◽  
Pavel Matousek ◽  
Helen L. Birch
Keyword(s):  
Raman Spectroscopy ◽  
Raman Spectra ◽  
Flexor Tendon ◽  
Biological Tissues ◽  
Ring Structure ◽  
Total N ◽  
Non Invasive ◽  
Age Related ◽  
Superficial Digital Flexor Tendon

The lack of clinical detection tools at the molecular level hinders our progression in preventing age-related tendon pathologies. Raman spectroscopy can rapidly and non-invasively detect tissue molecular compositions and has great potential for in vivo applications. In biological tissues, a highly fluorescent background masks the Raman spectral features and is usually removed during data processing, but including this background could help age differentiation since fluorescence level in tendons increases with age. Therefore, we conducted a stepwise analysis of fluorescence and Raman combined spectra for better understanding of the chemical differences between young and old tendons. Spectra were collected from random locations of vacuum-dried young and old equine tendon samples (superficial digital flexor tendon (SDFT) and deep digital flexor tendon (DDFT), total n = 15) under identical instrumental settings. The fluorescence-Raman spectra showed an increase in old tendons as expected. Normalising the fluorescence-Raman spectra further indicated a potential change in intra-tendinous fluorophores as tendon ages. After fluorescence removal, the pure Raman spectra demonstrated between-group differences in CH2 bending (1450 cm−1) and various ring-structure and carbohydrate-associated bands (1000–1100 cm−1), possibly relating to a decline in cellular numbers and an accumulation of advanced glycation end products in old tendons. These results demonstrated that Raman spectroscopy can successfully detect age-related tendon molecular differences.

Non-invasive in vivo Raman spectroscopy of the skin for diabetes screening

2017 ◽  
Author(s):  
Edgar Guevara ◽  
Juan Carlos Torres-Galvan ◽  
Miguel G. Ramirez Elias ◽  
Claudia Luevano-Contreras ◽  
Francisco Javier Gonzalez
Keyword(s):  
Raman Spectroscopy ◽  
Diabetes Screening ◽  
Non Invasive ◽  
In Vivo Raman Spectroscopy

scholarly journals Non-invasive chemically specific measurement of subsurface temperature in biological tissues using surface-enhanced spatially offset Raman spectroscopy

2016 ◽  
Vol 187 ◽  
pp. 329-339 ◽  
Author(s):  
Benjamin Gardner ◽  
Nicholas Stone ◽  
Pavel Matousek
Keyword(s):  
Raman Spectroscopy ◽  
High Sensitivity ◽  
Biological Tissues ◽  
Temperature Monitoring ◽  
Subsurface Temperature ◽  
Non Invasive ◽  
Wide Range ◽  
Subsurface Monitoring ◽  
Mean Square Errors

Here we demonstrate for the first time the viability of characterising non-invasively the subsurface temperature of SERS nanoparticles embedded within biological tissues using spatially offset Raman spectroscopy (SORS). The proposed analytical method (T-SESORS) is applicable in general to diffusely scattering (turbid) media and features high sensitivity and high chemical selectivity. The method relies on monitoring the Stokes and anti-Stokes bands of SERS nanoparticles in depth using SORS. The approach has been conceptually demonstrated using a SORS variant, transmission Raman spectroscopy (TRS), by measuring subsurface temperatures within a slab of porcine tissue (5 mm thick). Root-mean-square errors (RMSEs) of 0.20 °C were achieved when measuring temperatures over ranges between 25 and 44 °C. This unique capability complements the array of existing, predominantly surface-based, temperature monitoring techniques. It expands on a previously demonstrated SORS temperature monitoring capability by adding extra sensitivity stemming from SERS to low concentration analytes. The technique paves the way for a wide range of applications including subsurface, chemical-specific, non-invasive temperature analysis within turbid translucent media including: the human body, subsurface monitoring of chemical (e.g. catalytic) processes in manufacture quality and process control and research. Additionally, the method opens prospects for control of thermal treatment of cancer in vivo with direct non-invasive feedback on the temperature of mediating plasmonic nanoparticles.

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