scholarly journals Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model

The Analyst ◽  
2010 ◽  
Vol 135 (12) ◽  
pp. 3142 ◽  
Author(s):  
Paul I. Okagbare ◽  
Francis W. L. Esmonde-White ◽  
Steven A. Goldstein ◽  
Michael D. Morris
Keyword(s):  
Raman Spectroscopy ◽  
Bone Graft ◽  
Rat Model ◽  
In Vivo Evaluation ◽  
Non Invasive

scholarly journals A New Symmetrical Thiazolidinedione Derivative: In Silico Design, Synthesis, and In Vivo Evaluation on a Streptozotocin- Induced Rat Model of Diabetes

Processes ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1294
Author(s):  
Samuel Álvarez-Almazán ◽  
Gabriel Navarrete-Vázquez ◽  
Itzia Irene Padilla-Martínez ◽  
José Correa-Basurto ◽  
Diana Alemán-González-Duhart ◽  
...  
Keyword(s):  
Rat Model ◽  
In Silico ◽  
Female Rats ◽  
Therapeutic Effects ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
In Vivo Evaluation ◽  
Docking Simulations ◽  
Ppar Γ

By activating PPAR-γ, thiazolidinediones normalize glucose levels in animal models of type 2 diabetes and in patients with this pathology. The aim of the present study was to analyze 219 new derivatives in silico and select the best for synthesis, to be evaluated for acute oral toxicity in female rats and for control of diabetes-related parameters in a rat model of streptozotocin-induced diabetes. The best compound was chosen based on pharmacokinetic, pharmacodynamic, and toxicological parameters obtained in silico and binding orientation observed by docking simulations on PPAR-γ. Compound 1G was synthesized by a quick and easy Knoevenagel condensation. Acute oral toxicity was found at a dose greater than 2000 mg/Kg. Compound 1G apparently produces therapeutic effects similar to those of pioglitazone, decreasing glycaemia and triglyceride levels in diabetic animals, without liver damage. Moreover, it did not cause a significant weight gain and tended to reduce polydipsia and polyphagia, while diminishing systemic inflammation related to TNF-α and IL-6. It lowered the level of endogenous antioxidant molecules such as reduced glutathione and glutathione reductase. In conclusion, 1G may be a candidate for further testing as an euglycemic agent capable of preventing the complications of diabetes.

Non-invasive analysis of hormonal variations and effect of postmenopausal Vagifem treatment on women using in vivo high wavenumber confocal Raman spectroscopy

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from Solidago virgaurea L. (Asteraceae)

2021 ◽  
Vol 89 (2) ◽  
pp. 27
Author(s):  
Mircea Tămaş ◽  
Oliviu Vostinaru ◽  
Loredana Soran ◽  
Ildiko Lung ◽  
Ocsana Opris ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rat Model ◽  
Antihypertensive Effect ◽  
Chemical Constituents ◽  
In Vivo Evaluation ◽  
Dry Extract ◽  
The Balkans ◽  
Solidago Virgaurea ◽  
Anti Inflammatory

Solidago virgaurea L. is a perennial plant used in European traditional medicine as a diuretic or a remedy for inflammatory conditions of the urinary tract but also for gout, especially in the Balkans. The present study was focused on a preclinical, in vivo evaluation of antihyperuricemic, anti-inflammatory, and antihypertensive effects of a dry extract from S. virgaurea L. (ESV). Colorimetric and HPLC–MS techniques were used to identify the main chemical constituents of ESV. Antihyperuricemic effect of ESV was assessed in a rat model of hyperuricemia induced by the administration of potassium oxonate. Antihypertensive effect of ESV was evaluated in hyperuricemic rats by monitoring systolic blood pressure with a non-invasive blood-pressure recording system. The anti-inflammatory effect of ESV was tested using a rat model of paw edema. The main chemical constituents of ESV were rutin and phenolic acids represented by chlorogenic and caffeic acid. ESV demonstrated significant antihyperuricemic effects in rats due to an uricosuric mechanism. Additionally, ESV reduced the progression of arterial hypertension in hyperuricemic rats and also showed anti-inflammatory properties slightly inferior to diclofenac. The results suggest that ESV could be a natural remedy for the treatment of gout and protection against endothelial dysfunction caused by hyperuricemia.

scholarly journals Confocal Raman spectroscopy: Evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo

2019 ◽  
Vol 570 ◽  
pp. 118641 ◽  
Author(s):  
Christian J.F. Bertens ◽  
Shuo Zhang ◽  
Roel J. Erckens ◽  
Frank J.H.M. van den Biggelaar ◽  
Tos T.J.M. Berendschot ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Invasive Technique ◽  
Ketorolac Tromethamine ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals Non-invasive In Vivo Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS)

Theranostics ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 5899-5913 ◽  
Author(s):  
Fay Nicolson ◽  
Bohdan Andreiuk ◽  
Chrysafis Andreou ◽  
Hsiao-Ting Hsu ◽  
Scott Rudder ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
In Vivo Imaging ◽  
Non Invasive ◽  
Surface Enhanced

.alpha.-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model

1987 ◽  
Vol 30 (3) ◽  
pp. 536-541 ◽  
Author(s):  
Suvit Thaisrivongs ◽  
Donald T. Pals ◽  
Judy A. Lawson ◽  
Steve R. Turner ◽  
Douglas W. Harris
Keyword(s):  
Rat Model ◽  
In Vivo Evaluation ◽  
Inhibitory Peptides

In Vivo Evaluation of Demineralized Bone Matrix as a Bone Graft Substitute for Posterior Spinal Fusion

Spine ◽  
1995 ◽  
Vol 20 (8) ◽  
pp. 877-886 ◽  
Author(s):  
Stephen D. Cook ◽  
Jeanette E. Dalton ◽  
Ann B. Prewett ◽  
Thomas S. Whitecloud
Keyword(s):  
Bone Graft ◽  
Spinal Fusion ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Posterior Spinal Fusion ◽  
Bone Graft Substitute ◽  
In Vivo Evaluation ◽  
Demineralized Bone
Sign in / Sign up

Export Citation Format

Share Document