scholarly journals Non-invasive In Vivo Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS)

Theranostics ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 5899-5913 ◽  
Author(s):  
Fay Nicolson ◽  
Bohdan Andreiuk ◽  
Chrysafis Andreou ◽  
Hsiao-Ting Hsu ◽  
Scott Rudder ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
In Vivo Imaging ◽  
Non Invasive ◽  
Surface Enhanced

scholarly journals Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

2022 ◽  
Vol 6 (1) ◽  
pp. 31-49
Author(s):  
Kenry ◽  
Fay Nicolson ◽  
Louise Clark ◽  
Sajanlal R. Panikkanvalappil ◽  
Bohdan Andreiuk ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
In Vivo Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Non-invasive analysis of hormonal variations and effect of postmenopausal Vagifem treatment on women using in vivo high wavenumber confocal Raman spectroscopy

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals BIMG-08. DEUTERIUM MAGNETIC RESONANCE SPECTROSCOPY USING 2H-PYRUVATE ALLOWS NON-INVASIVE IN VIVO IMAGING OF TERT EXPRESSION IN BRAIN TUMORS

2021 ◽  
Vol 3 (Supplement_1) ◽  
pp. i2-i2
Author(s):  
Georgios Batsios ◽  
Celine Taglang ◽  
Meryssa Tran ◽  
Anne Marie Gillespie ◽  
Joseph Costello ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
In Vivo Imaging ◽  
Lactate Production ◽  
Telomere Maintenance ◽  
Resonance Spectroscopy ◽  
Low Grade ◽  
Non Invasive ◽  
Tert Expression

Abstract Telomere shortening constitutes a natural barrier to uncontrolled proliferation and all tumors must find a mechanism of maintaining telomere length. Most human tumors, including high-grade primary glioblastomas (GBMs) and low-grade oligodendrogliomas (LGOGs) achieve telomere maintenance via reactivation of the expression of telomerase reverse transcriptase (TERT), which is silenced in normal somatic cells. TERT expression is, therefore, a driver of tumor proliferation and, due to this essential role, TERT is also a therapeutic target. However, non-invasive methods of imaging TERT are lacking. The goal of this study was to identify magnetic resonance spectroscopy (MRS)-detectable metabolic biomarkers of TERT expression that will enable non-invasive visualization of tumor burden in LGOGs and GBMs. First, we silenced TERT expression by RNA interference in patient-derived LGOG (SF10417, BT88) and GBM (GS2) models. Our results linked TERT silencing to significant reductions in steady-state levels of NADH in all models. NADH is essential for the conversion of pyruvate to lactate, suggesting that measuring pyruvate flux to lactate could be useful for imaging TERT status. Recently, deuterium (2H)-MRS has emerged as a novel, clinically translatable method of monitoring metabolic fluxes in vivo. However, to date, studies have solely examined 2H-glucose and the use of [U-2H]pyruvate for non-invasive 2H-MRS has not been tested. Following intravenous injection of a bolus of [U-2H]pyruvate, lactate production was higher in mice bearing orthotopic LGOG (BT88 and SF10417) and GBM (GS2) tumor xenografts relative to tumor-free mice, suggesting that [U-2H]pyruvate has the potential to monitor TERT expression in vivo. In summary, our study, for the first time, shows the feasibility and utility of [U-2H]pyruvate for in vivo imaging. Importantly, since 2H-MRS can be implemented on clinical scanners, our results provide a novel, non-invasive method of integrating information regarding a fundamental cancer hallmark, i.e. TERT, into glioma patient management.

Preparation and Non-Invasive In-Vivo Imaging of Anti-Adhesion Barriers with Fluorescent Polymeric Marks

2009 ◽  
Vol 19 (4) ◽  
pp. 733-740 ◽  
Author(s):  
Shih-Rong Hsieh ◽  
Chi-Jung Chang ◽  
Tzong-Der Way ◽  
Po-Cheung Kwan ◽  
Tsung-Wei Hung
Keyword(s):  
In Vivo Imaging ◽  
Non Invasive

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

scholarly journals Confocal Raman spectroscopy: Evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo

2019 ◽  
Vol 570 ◽  
pp. 118641 ◽  
Author(s):  
Christian J.F. Bertens ◽  
Shuo Zhang ◽  
Roel J. Erckens ◽  
Frank J.H.M. van den Biggelaar ◽  
Tos T.J.M. Berendschot ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Invasive Technique ◽  
Ketorolac Tromethamine ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals Surface-enhanced Raman spectroscopy for in vivo biosensing

2017 ◽  
Vol 1 (8) ◽  
Author(s):  
Stacey Laing ◽  
Lauren E. Jamieson ◽  
Karen Faulds ◽  
Duncan Graham
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman
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