Morphine Withdrawal Reactions in Male and Female Mice

1976 ◽  
Vol 3 (2) ◽  
pp. 363-368 ◽  
Author(s):  
Kenneth Blum ◽  
Joseph D. Eubanks ◽  
Ben Wiggins ◽  
Jack E. Wallace
Keyword(s):  
Morphine Withdrawal ◽  
Male And Female ◽  
Female Mice

scholarly journals Male and female mice demonstrate divergent cellular responses in the bed nucleus of stria terminalis (BNST) following morphine withdrawal

2018 ◽  
Author(s):  
Brennon R. Luster ◽  
Elizabeth S. Cogan ◽  
Karl T. Schmidt ◽  
Dipanwita Pati ◽  
Melanie M. Pina ◽  
...  
Keyword(s):  
Opioid Analgesics ◽  
Cellular Responses ◽  
The United States ◽  
Morphine Withdrawal ◽  
Stria Terminalis ◽  
Male Mice ◽  
Male And Female ◽  
Bed Nucleus ◽  
Precipitated Withdrawal ◽  
Female Mice

AbstractThe United States is experiencing an opioid epidemic of significant proportions, imposing enormous fiscal and societal costs. While prescription opioid analgesics are essential for treating pain, the cessation of these drugs can induce a withdrawal syndrome, and thus opioid use often persists to alleviate or avoid these symptoms. Therefore, it is essential to understand the neurobiology underlying this critical window of withdrawal from opioid analgesics to prevent continued usage. To model this, we administered a low dose of morphine, and precipitated withdrawal with naloxone to investigate the behavioral and cellular responses in C57BL/6J male and female mice. Following 3 days of administration, both male and female mice sensitized to the repeated bouts of withdrawal, as evidenced by their composite global withdrawal score. Female mice exhibited increased withdrawal symptoms on some individual measures, but did not show characteristic weight loss observed in male mice. Because of its role in mediating withdrawal-associated behaviors, we examined neuronal excitability and inhibitory synaptic transmission in the bed nucleus of the stria terminalis (BNST) 24 hours following the final precipitated withdrawal. In male mice, morphine withdrawal increased spontaneous GABAergic signaling compared to controls. In contrast, morphine withdrawal decreased spontaneous GABAergic signaling, and increased BNST projection neuron excitability in female mice. Intriguingly, these opposing GABAergic effects were dependent on within slice excitability. Our findings suggest that male and female mice manifest divergent cellular responses in the BNST following morphine withdrawal, and alterations in BNST inhibitory signaling may be a significant factor contributing to the expression of behaviors following opioid withdrawal.

scholarly journals Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal

2019 ◽  
Vol 25 (3) ◽  
Author(s):  
Brennon R. Luster ◽  
Elizabeth S. Cogan ◽  
Karl T. Schmidt ◽  
Dipanwita Pati ◽  
Melanie M. Pina ◽  
...  
Keyword(s):  
Morphine Withdrawal ◽  
Stria Terminalis ◽  
Male And Female ◽  
Bed Nucleus ◽  
Inhibitory Transmission ◽  
Female Mice

Morphine withdrawal syndrome and its prevention with baclofen: Autoradiographic study of μ-opioid receptors in prepubertal male and female mice

Synapse ◽  
2006 ◽  
Vol 60 (2) ◽  
pp. 132-140 ◽  
Author(s):  
Silvina L. Diaz ◽  
Virginia G. Barros ◽  
Marta C. Antonelli ◽  
Modesto C. Rubio ◽  
Graciela N. Balerio
Keyword(s):  
Opioid Receptors ◽  
Withdrawal Syndrome ◽  
Autoradiographic Study ◽  
Morphine Withdrawal ◽  
Male And Female ◽  
Female Mice ◽  
Μ Opioid Receptors

Morphine withdrawal syndrome: Involvement of the dopaminergic system in prepubertal male and female mice

2005 ◽  
Vol 82 (4) ◽  
pp. 601-607 ◽  
Author(s):  
Silvina L. Diaz ◽  
Alma K. Kemmling ◽  
Modesto C. Rubio ◽  
Graciela N. Balerio
Keyword(s):  
Withdrawal Syndrome ◽  
Dopaminergic System ◽  
Morphine Withdrawal ◽  
Male And Female ◽  
Female Mice

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1999-P ◽  
Author(s):  
HYE LIM NOH ◽  
SUJIN SUK ◽  
RANDALL H. FRIEDLINE ◽  
KUNIKAZU INASHIMA ◽  
DUY A. TRAN ◽  
...  
Keyword(s):  
Energy Balance ◽  
Adult Male ◽  
Early Life ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Early Life Exposure ◽  
Fat Feeding
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