Baclofen prevents the elevated plus maze behavior and BDNF expression during naloxone precipitated morphine withdrawal in male and female mice

Synapse ◽  
2016 ◽  
Vol 70 (5) ◽  
pp. 187-197 ◽  
Author(s):  
Valeria T. Pedrón ◽  
André P. Varani ◽  
Graciela N. Balerio
Keyword(s):  
Elevated Plus Maze ◽  
Morphine Withdrawal ◽  
Bdnf Expression ◽  
Male And Female ◽  
Female Mice ◽  
Plus Maze

Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal

2009 ◽  
Vol 197 (2) ◽  
pp. 454-456 ◽  
Author(s):  
Sam G. Buckman ◽  
Stephen R. Hodgson ◽  
Rebecca S. Hofford ◽  
Shoshana Eitan
Keyword(s):  
Elevated Plus Maze ◽  
Morphine Withdrawal ◽  
Plus Maze

Dietary Soy Supplements Produce Opposite Effects on Anxiety in Intact Male and Female Rats in the Elevated Plus-Maze.

2005 ◽  
Vol 119 (2) ◽  
pp. 587-594 ◽  
Author(s):  
Heather B. Patisaul ◽  
Adele Blum ◽  
Jordan R. Luskin ◽  
Mark E. Wilson
Keyword(s):  
Elevated Plus Maze ◽  
Female Rats ◽  
Intact Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Plus Maze

scholarly journals Male and female mice demonstrate divergent cellular responses in the bed nucleus of stria terminalis (BNST) following morphine withdrawal

2018 ◽  
Author(s):  
Brennon R. Luster ◽  
Elizabeth S. Cogan ◽  
Karl T. Schmidt ◽  
Dipanwita Pati ◽  
Melanie M. Pina ◽  
...  
Keyword(s):  
Opioid Analgesics ◽  
Cellular Responses ◽  
The United States ◽  
Morphine Withdrawal ◽  
Stria Terminalis ◽  
Male Mice ◽  
Male And Female ◽  
Bed Nucleus ◽  
Precipitated Withdrawal ◽  
Female Mice

AbstractThe United States is experiencing an opioid epidemic of significant proportions, imposing enormous fiscal and societal costs. While prescription opioid analgesics are essential for treating pain, the cessation of these drugs can induce a withdrawal syndrome, and thus opioid use often persists to alleviate or avoid these symptoms. Therefore, it is essential to understand the neurobiology underlying this critical window of withdrawal from opioid analgesics to prevent continued usage. To model this, we administered a low dose of morphine, and precipitated withdrawal with naloxone to investigate the behavioral and cellular responses in C57BL/6J male and female mice. Following 3 days of administration, both male and female mice sensitized to the repeated bouts of withdrawal, as evidenced by their composite global withdrawal score. Female mice exhibited increased withdrawal symptoms on some individual measures, but did not show characteristic weight loss observed in male mice. Because of its role in mediating withdrawal-associated behaviors, we examined neuronal excitability and inhibitory synaptic transmission in the bed nucleus of the stria terminalis (BNST) 24 hours following the final precipitated withdrawal. In male mice, morphine withdrawal increased spontaneous GABAergic signaling compared to controls. In contrast, morphine withdrawal decreased spontaneous GABAergic signaling, and increased BNST projection neuron excitability in female mice. Intriguingly, these opposing GABAergic effects were dependent on within slice excitability. Our findings suggest that male and female mice manifest divergent cellular responses in the BNST following morphine withdrawal, and alterations in BNST inhibitory signaling may be a significant factor contributing to the expression of behaviors following opioid withdrawal.

scholarly journals Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats

2021 ◽  
Author(s):  
Adriaan W. Bruijnzeel ◽  
Azin Behnood-Rod ◽  
Wendi Malphurs ◽  
Ranjithkumar Chellian ◽  
Robert M. Caudle ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Field Test ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Female Rats ◽  
Male And Female ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Male And Female Rats ◽  
Plus Maze

AbstractThe prescription opioid oxycodone is widely used for the treatment of pain in humans. Oxycodone misuse is more common among people with an anxiety disorder than those without one. Therefore, oxycodone might be misused for its anxiolytic properties. We investigated if oxycodone affects anxiety-like behavior in adult male and female rats. The rats were treated with oxycodone (0.178, 0.32, 0.56, or 1 mg/kg), and anxiety-like behavior was investigated in the elevated plus-maze test. Immediately after the elevated plus-maze test, a small open field test was conducted to determine the effects of oxycodone on locomotor activity. In the elevated plus-maze test, oxycodone increased the percentage of time spent on the open arms, the percentage of open arm entries, time on the open arms, open arm entries, and the distance traveled. The males treated with vehicle had a lower percentage of open arm entries than the females treated with vehicle, and oxycodone treatment led to a greater increase in the percentage of open arm entries in the males than females. Furthermore, the females spent more time on the open arms, made more open arm entries, spent less time in the closed arms, and traveled a greater distance than the males. In the small open field test, treatment with oxycodone did not affect locomotor activity or rearing. Sex differences were observed; the females traveled a greater distance and displayed more rearing than the males. In conclusion, oxycodone decreases anxiety-like behavior in rats, and oxycodone has a greater anxiolytic-like effect in males than females.

scholarly journals Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and -Tocopherol Presents in the Extract of Leaves ofCissus sicyoidesL. (Vitaceae)

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Edvaldo Rodrigues de Almeida ◽  
Krissia Rayane de Oliveira Rafael ◽  
Geraldo Bosco Lindoso Couto ◽  
Ana Beatriz Matos Ishigami
Keyword(s):  
Elevated Plus Maze ◽  
Sodium Pentobarbital ◽  
Hydroalcoholic Extract ◽  
Male And Female ◽  
Aerial Parts ◽  
Plus Maze ◽  
Marble Burying ◽  
Males And Females ◽  
Behavioral Assays ◽  
Anticonvulsant Effects

The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts ofCissus sicyoidesL. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action fromC. sicyoidesL. extract on mice, probably due to the action of flavonoid(s), Linalool, and -tocopherol present in theC. sicyoidesleaves.

scholarly journals Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice

2019 ◽  
Author(s):  
Isabel M. Bravo ◽  
Brennon R. Luster ◽  
Meghan E. Flanigan ◽  
Patric J. Perez ◽  
Elizabeth S. Cogan ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Behavioral Responses ◽  
Opioid Use Disorder ◽  
Opioid Withdrawal ◽  
Neural Mechanisms ◽  
Morphine Dependence ◽  
Behavioral Adaptation ◽  
Opioid Use ◽  
Male And Female ◽  
Plus Maze

AbstractPersons suffering from opioid use disorder (OUD) experience long-lasting dysphoric symptoms well into extended periods of withdrawal. This protracted withdrawal syndrome is notably characterized by heightened anxiety. Here we investigate if an exacerbated withdrawal model of acute morphine dependence results in lasting behavioral adaptation 6 weeks into forced abstinence. We found that our exacerbated morphine withdrawal paradigm produced distinct impairments in elevated-plus maze, open field, and social interaction tests in male and female mice. These findings will be relevant for future investigation examining the neural mechanisms underlying these behaviors, and will aid in uncovering physiological sex differences in response to opioid withdrawal.

Increased elevated plus maze open-arm time in mice during naloxone-precipitated morphine withdrawal

2008 ◽  
Vol 19 (8) ◽  
pp. 805-811 ◽  
Author(s):  
Stephen R. Hodgson ◽  
Rebecca S. Hofford ◽  
Chris J. Norris ◽  
Shoshana Eitan
Keyword(s):  
Elevated Plus Maze ◽  
Morphine Withdrawal ◽  
Plus Maze
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