scholarly journals Need of Nutrigenomic Studies for the Prevention and Treatment of Mood and Neurodegenerative Disorders

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
M. Atif Raza Cheema ◽  
Khalid Mahmood
Keyword(s):  
Neurodegenerative Disorders ◽  
Prevention And Treatment

scholarly journals Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study

MedChemComm ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 1892-1899
Author(s):  
Pasquale Linciano ◽  
Barbara De Filippis ◽  
Alessandra Ammazzalorso ◽  
Pasquale Amoia ◽  
Felisa Cilurzo ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Neurodegenerative Disorders ◽  
Pharmacokinetic Properties ◽  
Prevention And Treatment ◽  
Ppar Agonists ◽  
Therapeutic Opportunity

PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB.

Targeting MicroRNAs in Prevention and Treatment of Neurodegenerative Disorders

2015 ◽  
Vol 76 (7) ◽  
pp. 397-418 ◽  
Author(s):  
Smriti Gupta ◽  
Savita Verma ◽  
Shrikant Mantri ◽  
Nancy E. Berman ◽  
Rajat Sandhir
Keyword(s):  
Neurodegenerative Disorders ◽  
Prevention And Treatment

Insights into amyloid disease from fly models

2014 ◽  
Vol 56 ◽  
pp. 69-83 ◽  
Author(s):  
Ko-Fan Chen ◽  
Damian C. Crowther
Keyword(s):  
Drosophila Melanogaster ◽  
Neurodegenerative Disorders ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Disease Pathogenesis ◽  
Amyloid Aggregates ◽  
Aβ Amyloid ◽  
Polypeptide Chains ◽  
Amyloid Diseases

The formation of amyloid aggregates is a feature of most, if not all, polypeptide chains. In vivo modelling of this process has been undertaken in the fruitfly Drosophila melanogaster with remarkable success. Models of both neurological and systemic amyloid diseases have been generated and have informed our understanding of disease pathogenesis in two main ways. First, the toxic amyloid species have been at least partially characterized, for example in the case of the Aβ (amyloid β-peptide) associated with Alzheimer's disease. Secondly, the genetic underpinning of model disease-linked phenotypes has been characterized for a number of neurodegenerative disorders. The current challenge is to integrate our understanding of disease-linked processes in the fly with our growing knowledge of human disease, for the benefit of patients.

The Need for Aggressive Pursuit of Healthy Childhood Voices

1989 ◽  
Vol 20 (1) ◽  
pp. 102-107 ◽  
Author(s):  
Joel C. Kahane ◽  
Robert Mayo
Keyword(s):  
Early Identification ◽  
Voice Disorders ◽  
Prevention Programs ◽  
Incidence Trends ◽  
Aggressive Management ◽  
Prevention And Treatment ◽  
Current Incidence

In this paper we argue for the aggressive management of voice disorders. Aggressive management includes early identification, prevention, and treatment of voice disorders. The argument for aggressive management is supported by current incidence trends, laryngologists' expectations, and the benefits of prevention programs.

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