scholarly journals Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study

MedChemComm ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 1892-1899
Author(s):  
Pasquale Linciano ◽  
Barbara De Filippis ◽  
Alessandra Ammazzalorso ◽  
Pasquale Amoia ◽  
Felisa Cilurzo ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Neurodegenerative Disorders ◽  
Pharmacokinetic Properties ◽  
Prevention And Treatment ◽  
Ppar Agonists ◽  
Therapeutic Opportunity

PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB.

scholarly journals Determination of molar refractions and Abraham descriptors for tris(acetylacetonato)chromium(iii), tris(acetylacetonato)iron(iii) and tris(acetylacetonato)cobalt(iii)

2017 ◽  
Vol 41 (23) ◽  
pp. 14259-14265 ◽  
Author(s):  
Michael H. Abraham ◽  
William E. Acree ◽  
Anthony F. Fucaloro ◽  
Andrew W. Zanella
Keyword(s):  
Physicochemical Properties ◽  
Chemical Properties

Descriptors for tris(acetylacetonato) complexes of Cr(iii), Fe(iii) and Co(iii) can be used to assess chemical properties of the complexes and to predict numerous physicochemical properties.

Determination of pharmacokinetic properties of clozapine and norclozapine in Korean schizophrenia patients

2009 ◽  
Vol 24 (3) ◽  
pp. 139-144 ◽  
Author(s):  
Seung-Tae Lee ◽  
Seunghyong Ryu ◽  
Hee Jung Nam ◽  
Soo-Youn Lee ◽  
Kyung Sue Hong
Keyword(s):  
Pharmacokinetic Properties

Physicochemical Properties of a New Multicomponent Cosolvent System for the pKa Determination of Poorly Soluble Pharmaceutical Compounds

2007 ◽  
Vol 90 (8) ◽  
pp. 1538-1553 ◽  
Author(s):  
Karl J. Box ◽  
Gergely Völgyi ◽  
Rebeca Ruiz ◽  
John E. Comer ◽  
Krisztina Takács-Novák ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Pharmaceutical Compounds ◽  
Poorly Soluble ◽  
Pka Determination

Relative hydrogen index as a fast method for the simultaneous determination of physicochemical properties of petroleum fractions

Fuel ◽  
2017 ◽  
Vol 210 ◽  
pp. 41-48 ◽  
Author(s):  
Lúcio L. Barbosa ◽  
Luciana F. Montes ◽  
Flávio V.C. Kock ◽  
Vinícius G. Morgan ◽  
Andre Souza ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Simultaneous Determination ◽  
Hydrogen Index ◽  
Fast Method ◽  
Petroleum Fractions

scholarly journals Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2716 ◽  
Author(s):  
Tun-Pin Hsueh ◽  
Tung-Hu Tsai
Keyword(s):  
Bioactive Compounds ◽  
Pharmacokinetic Study ◽  
High Performance ◽  
Low Dose ◽  
Rat Plasma ◽  
Herbal Formula ◽  
Preclinical Pharmacokinetics ◽  
Pharmacokinetic Properties ◽  
Liquid Chromatography Tandem Mass

The herbal formula Yin-Chen-Hao-Tang has been reported to have anti-fibrosis properties. The aim of this study was to reveal the pharmacokinetic characteristics of bioactive compounds in this herbal formula. A new high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous determination of scoparone, geniposide and rhein in rat plasma. A pharmaceutical herbal powder was administered to rats at doses of 1 g/kg and 3 g/kg orally. The method showed excellent linearity (r2 > 0.999) and validation was successfully conducted for the pharmacokinetic study. The results show that the Cmax values and areas under the curve of scoparone, geniposide and rhein were higher and not proportional to the dose in rat plasma, while the Tmax and half-life values were consistent in the group that received 1 g/kg. The clearance of the higher dose (3 g/kg) did not decrease proportionally to that of the low dose. The results showed the nonlinear pharmacokinetic properties of scoparone, geniposide and rhein in Yin-Chen-Hao-Tang that suggested possible accumulation of bioactive compounds through oral administration. This pharmacokinetic study reveals that an increased dose of this herbal formula would largely increase the maximum concentration and bioavailability of scoparone, geniposide and rhein.

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