scholarly journals Algorithm of the Rehabilitation of Patients with Pigmentary Glaucoma

2019 ◽  
Vol 4 (4) ◽  
pp. 11-19
Author(s):  
N. V. Volkova ◽  
A. S. Grischuk ◽  
A. A. Veselov ◽  
L. V. Shvets
Keyword(s):  
Nerve Fiber ◽  
Load Test ◽  
Pigmentary Glaucoma ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Pathologic Process ◽  
Nerve Fiber Layer ◽  
Medication Therapy ◽  
Therapeutic Measures ◽  
Zone State

Background. Irreversible changes in corneoscleral trabecula lead to persistent hydrodynamic disturbances not only in pigmentary glaucoma but also in pigmentary dispersion syndrome. In these cases isolated laser iridectomy cannot compensate ophthalmotonus and stabilize pathologic process.Aim: to evaluate effectiveness of treatment and rehabilitation algorithms for patients with pigmentary glaucoma, depending on irido-ciliary zone state and IOP level.Materials and methods. 12 people with pigmentary dispersion syndrome in manifestation stage and 20 people with pigmentary glaucoma were examined.Results. In pigmentary glaucoma, initial IOP level was 28.2 ± 3.79 mm Hg, coefficient of outflow easiness was 0.09 ± 0.03 (p < 0.001). In pigmentary dispersion syndrome at stage of manifestation, hydrodynamic shifts were latent with IOP of 19.03 ± 0.79 mm Hg: positive load test, reduced coefficient of outflow easiness 0.15 ± 0.07 (p < 0.001). Significant changes were found in nerve fiber layer, retinal ganglion complex and perimetric indices in both groups, but they were irreversible in patients with pigmentary glaucoma. Laser iridectomy was performed in 100 % of cases in pigmentary dispersion syndrome and in 75 % of cases in pigmentary glaucoma. Local medication therapy was prescribed in 100 % of cases for IOL decrease in manifestation stage of pigmentary dispersion syndrome, and in pigment glaucoma it was effective in 34 %. In remaining cases fistulizing operations were performed initially.Conclusion. The algorithm of the rehabilitation of patients with pigmentary dispersion syndrome in stage of manifestation and with pigmentary glaucoma has character of not preventive, but therapeutic measures, including not only laser iridectomy, but also a hypotensive regimen in 100 % of cases. In pigmentary glaucoma, fistulizing operation can be considered as a starting hypotensive option.

scholarly journals Nerve Fiber Layer Thinning Lags Retinal Ganglion Cell Density Following Crush Axonopathy

2014 ◽  
Vol 55 (10) ◽  
pp. 6505 ◽  
Author(s):  
Gustavo C. Munguba ◽  
Sanja Galeb ◽  
Yuan Liu ◽  
David C. Landy ◽  
Daisy Lam ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Cell Density ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer

scholarly journals β-alanine supplementation induces taurine depletion and causes alterations of the retinal nerve fiber layer and axonal transport by retinal ganglion cells

2019 ◽  
Vol 188 ◽  
pp. 107781 ◽  
Author(s):  
Diego García-Ayuso ◽  
Johnny Di Pierdomenico ◽  
Francisco J. Valiente-Soriano ◽  
Ana Martínez-Vacas ◽  
Marta Agudo-Barriuso ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Axonal Transport ◽  
Retinal Ganglion Cells ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

scholarly journals Estimated Retinal Ganglion Cell Counts in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects

2013 ◽  
Vol 156 (3) ◽  
pp. 578-587.e1 ◽  
Author(s):  
Andrew J. Tatham ◽  
Robert N. Weinreb ◽  
Linda M. Zangwill ◽  
Jeffrey M. Liebmann ◽  
Christopher A. Girkin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Retinal Nerve Fiber Layer ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Cell Counts ◽  
Retinal Nerve Fiber

scholarly journals Retinal Ganglion Cell Layer Thinning Followed By Retinal Nerve Fiber Layer Thinning In Patients with Uveitis

2016 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Ganglion Cell Layer

In the model of experimentally induced ischemia- reperfusion injury, retinal ganglion cells (RGC) expressing the gene AP-1 result apoptosis. The inflammation mediators, such as TNF-α, IL-1β, etc. lead RGC to apoptosis, that may lead the thinning of the retinal ganglion cell layer (RGCL) followed by the optic nerve fiber layer (RNFL) thinning. In his study we observed retinal ganglion cell and optic nerve fiber layer thinning in patients with various uveitis, that the pathological features appear obliterative vasculitis, using the optical coherence tomography (OCT) imaging analyses. Subjects were 182 eyes of 91 uveitis patients without glaucoma. Comparison were patients with normal tension glaucoma (NTG). Image analyses were conducted with 3D OCT-2000. As a result average RGCL thickness values in the patients with uveitis were significantly(p<0.01) thinner than those in healthies. Cycle scan findings of RNFL around the optic disc in the patients with uveitis showed significant thinning especially at nasal side. The retinal ganglion cell layer thinning followed by the retinal nerve fiber thinning in the patients with various uveitis was observed, and the thinning was similar to that in patients with glaucoma. The observation of RGCL and RNFL thickness may be useful for the diagnosis and the follow-up of uveitis.

scholarly journals Tissue engineering the retinal ganglion cell nerve fiber layer

Biomaterials ◽  
2013 ◽  
Vol 34 (17) ◽  
pp. 4242-4250 ◽  
Author(s):  
Karl E. Kador ◽  
Ramon B. Montero ◽  
Praseeda Venugopalan ◽  
Jonathan Hertz ◽  
Allison N. Zindell ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer

scholarly journals Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance

2021 ◽  
Vol 22 (4) ◽  
pp. 1724
Author(s):  
Tsunehiko Ikeda ◽  
Kimitoshi Nakamura ◽  
Takaki Sato ◽  
Teruyo Kida ◽  
Hidehiro Oku
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Internal Limiting Membrane ◽  
Retinal Ganglion ◽  
Ilm Peeling ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Optic Nerve Fiber

Dissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in macular diseases. However, the cause of DONFL remains largely unknown. Optical coherence tomography (OCT) findings have indicated that the nerve fiber layer (NFL) and ganglion cells are likely to have been damaged in patients with DONFL appearance. Since DONFL appearance occurs at a certain postoperative period, it is unlikely to be retinal damage directly caused by ILM peeling because apoptosis occurs at a certain period after tissue damage and/or injury. However, it may be due to ILM peeling-induced apoptosis in the retinal tissue. Anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). The anoikis-related proteins βA3/A1 crystallin and E-cadherin are reportedly expressed in retinal ganglion cells. Thus, we theorize that one possible cause of DONFL appearance is ILM peeling-induced anoikis in retinal ganglion cells.

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