Iron(III) Chloride Hexahydrate Catalysed Efficient Synthesis of 3-substituted Indoles Via Micheal Addition Reaction

2018 ◽  
Vol 8 (4) ◽  
pp. 671-676
Author(s):  
Shrikant Anpat ◽  
Vijay V. Dabholkar ◽  
Sandip Gulve ◽  
Karthik Krishnan
Keyword(s):  
Addition Reaction ◽  
Efficient Synthesis ◽  
Chloride Hexahydrate

Aryl thiol-vinyl azide coupling reaction and thiol-vinyl azide coupling/cyclization cascade: efficient synthesis of β-ketosulfides and arene-fused 5-methylene-2-pyrrolidinone derivatives

2021 ◽  
Author(s):  
Yong Wang ◽  
Yu-Jiao Wang ◽  
Xian-Cheng Liang ◽  
Mei-Hua Shen ◽  
Hua-Dong Xu ◽  
...  
Keyword(s):  
Addition Reaction ◽  
Coupling Reaction ◽  
The Other ◽  
Efficient Synthesis ◽  
Coupling Process

The addition reaction of thiol to vinyl azide has been extensively studied. Variously substituted aryl thiols are all viable for this coupling process. The scope of the other partner is...

Efficient Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1183-1186 ◽  
Author(s):  
Nobuhiro Obara ◽  
Takeshi Watanabe ◽  
Tomohiro Asakawa ◽  
Toshiyuki Kan ◽  
Takao Tanaka
Keyword(s):  
Michael Addition ◽  
Convenient Method ◽  
Addition Reaction ◽  
Efficient Synthesis ◽  
Michael Addition Reaction ◽  
One Pot ◽  
Simple Method ◽  
The Michael Addition

A convenient method for synthesizing 3-amino-1,5-benzodiazepine-2-one via the Michael addition reaction of o-phenylenediamine with dehydroalanine ester derivatives, followed by cyclization, was developed. This simple method was used to obtain a variety of N-substituted 3-amino-1,5-benzodiazepine-2-ones in one pot with good yields.

The facile and efficient synthesis of novel monocyclic cis-β-lactams conjugates having 1-methyl-1H-imidazole-2-thio nucleus

2021 ◽  
Author(s):  
Vedeshwar Narayan Singh ◽  
Sitaram Sharma
Keyword(s):  
Addition Reaction ◽  
Acyl Chloride ◽  
Efficient Synthesis

In this paper, the facile and efficient synthesis of novel monocyclic cis-β-lactam conjugates having 1-methyl-1H-imidazole-2-thiol nucleus has been developed through ketene-imine [2+2] cyclo-addition reaction of acyl chloride and different Schiff’s...

Ultrasound-assisted synthesis of β-enaminone derivatives via Tin(Ⅳ)-catalyzed addition reaction from β-dicarbonyl compounds with nitriles

2021 ◽  
Vol 19 ◽  
Author(s):  
Shuchen Pei ◽  
Jinhua Yang ◽  
Jieyu Wang ◽  
Kangyao Yuan ◽  
Ziqiang Li
Keyword(s):  
Room Temperature ◽  
Addition Reaction ◽  
Ultrasound Irradiation ◽  
Irradiation Condition ◽  
Efficient Synthesis ◽  
Dicarbonyl Compounds ◽  
Ultrasound Assisted

Abstract: An efficient and eco-friendly approach for the synthesis of β-enaminone derivatives is described, which is through the addition of nitriles with β-dicarbonyl compounds under ultrasound irradiation condition at room temperature. The scope and limitation of this strategy are also discussed. A variety of substituted amides can be obtained in moderate to good yields. We hope that this protocol for the efficient synthesis of β-enaminones will offer insights in further investigations.

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