Molecular basis of ovarian development and function

Skeletal muscles arise from diverse embryonic origins, yet converge on common regulatory programs involving muscle regulatory factor (MRF)-family genes. Here, we compare the molecular basis of myogenesis in two separate muscle groups in the simple chordate Ciona: the atrial and oral siphon muscles. Here, we describe the ontogeny of OSM progenitors and characterize the clonal origins of OSM founders to compare mechanisms of OSM specification to what has been established for ASM. We determined that, as is the case in the ASM, Ebf and Tbx1/10 are both expressed and function upstream of Mrf in the OSM founder cells. However, regulatory relationships between Tbx1/10, Ebf and Mrf differ between the OSM and ASM lineages: while Tbx1/10, Ebf and Mrf form a linear cascade in the ASM, Ebf and Tbx1/10 are expressed in the inverse temporal order and are required together in order to activate Mrf in the OSM founder cells.

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Cardiomyopathy Classification: Ongoing Debate in the Genomics Era

Biochemistry Research International ◽

10.1155/2012/796926 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 10

Author(s):

Charles McCartan ◽

Robert Mason ◽

S. R. Jayasinghe ◽

Lyn R. Griffiths

Keyword(s):

Adverse Effects ◽

Genetic Information ◽

Molecular Basis ◽

Genetic Basis ◽

Muscle Size ◽

Systemic Diseases ◽

Ongoing Debate ◽

Traditional Classification ◽

And Function

Cardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. Although our knowledge of the exact basis of many of the disease processes of cardiomyopathies is still in its infancy, it is important to have a classification system that has the ability to incorporate the coming tide of molecular and genetic information. This paper discusses how the traditional classification of cardiomyopathies based on morphology has evolved due to rapid advances in our understanding of the genetic and molecular basis for many of these clinical entities.

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Molecular Basis of Pancreas Development and Function

10.1007/978-1-4615-1669-9 ◽

2001 ◽

Cited By ~ 1

Keyword(s):

Molecular Basis ◽

Pancreas Development ◽

And Function

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