scholarly journals Essential role of BRCA2 in ovarian development and function

2019 ◽  
Author(s):  
Weinberg-Shukron A ◽  
Rachmiel M ◽  
Renbaum P ◽  
Gulsuner S ◽  
Walsh T ◽  
...  
Keyword(s):  
Essential Role ◽  
Ovarian Development ◽  
And Function

scholarly journals Essential Role of Septin 7 in Skeletal Muscle Structure and Function

2020 ◽  
Vol 118 (3) ◽  
pp. 258a
Author(s):  
Laszlo Csernoch ◽  
Mónika Gönczi ◽  
Zsolt Ráduly ◽  
László Szabó ◽  
Nóra Dobrosi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Essential Role ◽  
Structure And Function ◽  
Muscle Structure ◽  
And Function

scholarly journals Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

2000 ◽  
Vol 165 (4) ◽  
pp. 1738-1742 ◽  
Author(s):  
Ari Hashimoto ◽  
Kiyoshi Takeda ◽  
Muneo Inaba ◽  
Masayuki Sekimata ◽  
Tsuneyasu Kaisho ◽  
...  
Keyword(s):  
B Cell ◽  
Phospholipase C ◽  
Essential Role ◽  
Cell Development ◽  
B Cell Development ◽  
Cutting Edge ◽  
And Function

Understanding the relationship between the microbiome and the structure and function of the pig gastrointestinal tract

2022 ◽  
pp. 165-178
Author(s):  
Chunlong Mu ◽  
◽  
Weiyun Zhu ◽  
Keyword(s):  
Gut Microbiome ◽  
Amino Acid Metabolism ◽  
Essential Role ◽  
Short Chain Fatty Acids ◽  
Structure And Function ◽  
Host Interaction ◽  
Epithelial Structure ◽  
And Function ◽  
The Relationship

The gut epithelium acts as a barrier to the gut environment. The integrity of the epithelial structure and function is thus critical for microbiome-host interaction. The gut microbiome can regulate the utilization and synthesis of mucin, the expressions of the intercellular junction complex, and the functioning of specific epithelial cells, such as enterochromaffin cells and stem cells in pigs. The factors involved include microbial metabolites, especially short-chain fatty acids and host-microbe co-metabolism. Recent studies have revealed the essential role of amino acid metabolism in regulating the gut microbiome and epithelial barrier. This chapter discusses how the pig gut microbiome modulates epithelial structure and function, highlighting findings that reflect the relationship between the gut microbiome, intestinal structure and function.

scholarly journals Essential Role ofBRCA2in Ovarian Development and Function

2018 ◽  
Vol 379 (11) ◽  
pp. 1042-1049 ◽  
Author(s):  
Ariella Weinberg-Shukron ◽  
Mariana Rachmiel ◽  
Paul Renbaum ◽  
Suleyman Gulsuner ◽  
Tom Walsh ◽  
...  
Keyword(s):  
Essential Role ◽  
Ovarian Development ◽  
And Function

scholarly journals Essential Role of Developmentally Activated Hypoxia-Inducible Factor 1α for Cardiac Morphogenesis and Function

2008 ◽  
Vol 103 (10) ◽  
pp. 1139-1146 ◽  
Author(s):  
Jaya Krishnan ◽  
Preeti Ahuja ◽  
Sereina Bodenmann ◽  
Don Knapik ◽  
Evelyne Perriard ◽  
...  
Keyword(s):  
Essential Role ◽  
Hypoxia Inducible Factor ◽  
Cardiac Morphogenesis ◽  
Hypoxia Inducible Factor 1Α ◽  
And Function

scholarly journals Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function

2021 ◽  
Author(s):  
Jayati Basu ◽  
Bernardo S. Reis ◽  
Suraj Peri ◽  
Jikun Zha ◽  
Xiang Hua ◽  
...  
Keyword(s):  
T Cell ◽  
Essential Role ◽  
Cd4 T Cell ◽  
Cell Identity ◽  
And Function

scholarly journals Genetic disruption of Plasmodium falciparum Merozoite surface antigen 180 (PfMSA180) suggests an essential role during parasite egress from erythrocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vanndita Bahl ◽  
Kritika Chaddha ◽  
Syed Yusuf Mian ◽  
Anthony A. Holder ◽  
Ellen Knuepfer ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Surface Antigen ◽  
Essential Role ◽  
Gene Knockout ◽  
Intervention Strategy ◽  
Merozoite Surface Antigen ◽  
Erythrocytic Cycle ◽  
And Function ◽  
Parasite Egress

AbstractPlasmodium falciparum, the parasite responsible for severe malaria, develops within erythrocytes. Merozoite invasion and subsequent egress of intraerythrocytic parasites are essential for this erythrocytic cycle, parasite survival and pathogenesis. In the present study, we report the essential role of a novel protein, P. falciparum Merozoite Surface Antigen 180 (PfMSA180), which is conserved across Plasmodium species and recently shown to be associated with the P. vivax merozoite surface. Here, we studied MSA180 expression, processing, localization and function in P. falciparum blood stages. Initially we examined its role in invasion, a process mediated by multiple ligand-receptor interactions and an attractive step for targeting with inhibitory antibodies through the development of a malaria vaccine. Using antibodies specific for different regions of PfMSA180, together with a parasite containing a conditional pfmsa180-gene knockout generated using CRISPR/Cas9 and DiCre recombinase technology, we demonstrate that this protein is unlikely to play a crucial role in erythrocyte invasion. However, deletion of the pfmsa180 gene resulted in a severe egress defect, preventing schizont rupture and blocking the erythrocytic cycle. Our study highlights an essential role of PfMSA180 in parasite egress, which could be targeted through the development of a novel malaria intervention strategy.

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