scholarly journals Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain

10.2741/1883 ◽  
2006 ◽  
Vol 11 (1) ◽  
pp. 1289 ◽  
Author(s):  
Yvan Gasche
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Matrix Metalloproteinases ◽  
Ischemic Brain ◽  
The Central Nervous System

Consequences of Anoxia and Ischemia to the Brain

2019 ◽  
pp. 86-91
Author(s):  
Jennifer E. Fugate
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Injury ◽  
Cerebral Edema ◽  
Secondary Injury ◽  
Neurologic Manifestations ◽  
Ischemic Brain ◽  
Electrolyte Disturbances ◽  
The Central Nervous System ◽  
The Brain

Systemic illness can have an abrupt and sometimes profound effect on the central nervous system. Organ failure and acute electrolyte disturbances may cause neurologic manifestations that are often accompanied by a decline in consciousness. Secondary injury is characterized by demyelination, cerebral edema, and anoxic-ischemic brain injury.

scholarly journals The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP- 3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis

2018 ◽  
Vol 19 (12) ◽  
pp. 4128 ◽  
Author(s):  
Natalia Łanocha-Arendarczyk ◽  
Irena Baranowska-Bosiacka ◽  
Izabela Gutowska ◽  
Agnieszka Kolasa-Wołosiuk ◽  
Karolina Kot ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Matrix Metalloproteinases ◽  
Defense Mechanism ◽  
Pathological Process ◽  
Tissue Inhibitors ◽  
Immunological Status ◽  
The Central Nervous System ◽  
Increased Activity

The pathological process occurring within the central nervous system (CNS) as a result of the infection by Acanthamoeba spp. is not fully understood. Therefore, the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,- 9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host’s immunological status. Our results showed that Acanthamoeba spp. infection can change the levels of MMP and TIMP in the CNS and may be amenable targets for limiting amoebic encephalitis. The increase in the activity of matrix metalloproteinases during acanthamoebiasis may be primarily the result of inflammation process, probably an increased activity of proteolytic processes, but also (to a lesser extent) a defense mechanism preventing the processes of neurodegeneration.

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