Matrix Metalloproteinases in the Central Nervous System

10.1142/p390 ◽  
2005 ◽  
Author(s):  
Katherine Conant ◽  
Paul E Gottschall
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Matrix Metalloproteinases ◽  
The Central Nervous System

scholarly journals The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP- 3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis

2018 ◽  
Vol 19 (12) ◽  
pp. 4128 ◽  
Author(s):  
Natalia Łanocha-Arendarczyk ◽  
Irena Baranowska-Bosiacka ◽  
Izabela Gutowska ◽  
Agnieszka Kolasa-Wołosiuk ◽  
Karolina Kot ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Matrix Metalloproteinases ◽  
Defense Mechanism ◽  
Pathological Process ◽  
Tissue Inhibitors ◽  
Immunological Status ◽  
The Central Nervous System ◽  
Increased Activity

The pathological process occurring within the central nervous system (CNS) as a result of the infection by Acanthamoeba spp. is not fully understood. Therefore, the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,- 9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host’s immunological status. Our results showed that Acanthamoeba spp. infection can change the levels of MMP and TIMP in the CNS and may be amenable targets for limiting amoebic encephalitis. The increase in the activity of matrix metalloproteinases during acanthamoebiasis may be primarily the result of inflammation process, probably an increased activity of proteolytic processes, but also (to a lesser extent) a defense mechanism preventing the processes of neurodegeneration.

scholarly journals Expression of matrix metalloproteinases in Naegleria fowleri and their role in invasion of the central nervous system

Microbiology ◽  
2017 ◽  
Vol 163 (10) ◽  
pp. 1436-1444 ◽  
Author(s):  
Charlton Lam ◽  
Melissa Jamerson ◽  
Guy Cabral ◽  
Ana Maris Carlesso ◽  
Francine Marciano-Cabral
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Matrix Metalloproteinases ◽  
Naegleria Fowleri ◽  
The Central Nervous System ◽  
Nægleria Fowleri
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