scholarly journals Tissue inhibitor of metalloproteinase (TIMP)-1: The TIMPed balance of matrix metalloproteinases in the central nervous system

2003 ◽  
Vol 74 (6) ◽  
pp. 801-806 ◽  
Author(s):  
Jessica Gardner ◽  
Anuja Ghorpade
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Matrix Metalloproteinases ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
The Central Nervous System

scholarly journals The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP- 3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis

2018 ◽  
Vol 19 (12) ◽  
pp. 4128 ◽  
Author(s):  
Natalia Łanocha-Arendarczyk ◽  
Irena Baranowska-Bosiacka ◽  
Izabela Gutowska ◽  
Agnieszka Kolasa-Wołosiuk ◽  
Karolina Kot ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Matrix Metalloproteinases ◽  
Defense Mechanism ◽  
Pathological Process ◽  
Tissue Inhibitors ◽  
Immunological Status ◽  
The Central Nervous System ◽  
Increased Activity

The pathological process occurring within the central nervous system (CNS) as a result of the infection by Acanthamoeba spp. is not fully understood. Therefore, the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,- 9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host’s immunological status. Our results showed that Acanthamoeba spp. infection can change the levels of MMP and TIMP in the CNS and may be amenable targets for limiting amoebic encephalitis. The increase in the activity of matrix metalloproteinases during acanthamoebiasis may be primarily the result of inflammation process, probably an increased activity of proteolytic processes, but also (to a lesser extent) a defense mechanism preventing the processes of neurodegeneration.

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