scholarly journals The epidemiological transition

2021 ◽  
Vol 2 (1) ◽  
pp. 8-20
Author(s):  
M., H. Wahdan
Keyword(s):  
Infectious Diseases ◽  
Causes Of Death ◽  
Transformation Process ◽  
Noncommunicable Diseases ◽  
Epidemiological Transition ◽  
Continuous Transformation ◽  
Changing Patterns ◽  
Health And Disease

The epidemiological transition was thought to be a unidirectional process, beginning when infectious diseases were predominant and ending when noncommunicable diseases dominated the causes of death. It is now evident that this transition is more complex and dynamic where health and disease evolve in diverse ways. It is rather a continuous transformation process with some diseases disappearing and others re-emerging. This paper addresses the mechanisms involved and the indicators that demonstrate the changing patterns of diseases

scholarly journals C�te d�Ivoire Dual Burden of Disease (CoDuBu): Study Protocol to Investigate the Co-occurrence of Chronic Infections and Noncommunicable Diseases in Rural Settings of Epidemiological Transition (Preprint)

2017 ◽  
Author(s):  
Ikenna C Eze ◽  
Clémence Esse ◽  
Fidèle K Bassa ◽  
Siaka Koné ◽  
Felix Acka ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Risk Factors ◽  
Blood Pressure ◽  
Health Care ◽  
Infectious Diseases ◽  
Noncommunicable Diseases ◽  
Epidemiological Transition ◽  
Middle Income ◽  
Middle Income Countries ◽  
Dual Burden

BACKGROUND Individual-level concomitance of infectious diseases and noncommunicable diseases (NCDs) is poorly studied, despite the reality of this dual disease burden for many low- and middle-income countries (LMICs). OBJECTIVE This study protocol describes the implementation of a cohort and biobank aiming for a better understanding of interrelation of helminth and Plasmodium infections with NCD phenotypes like metabolic syndrome, hypertension, and diabetes. METHODS A baseline cross-sectional population-based survey was conducted over one year, in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d’Ivoire. We randomly identified 1020 consenting participants aged ≥18 years in three communities (Taabo-Cité, Amani-Ménou, and Tokohiri) reflecting varying stages of epidemiological transition. Participants underwent health examinations consisting of NCD phenotyping (anthropometry, blood pressure, renal function, glycemia, and lipids) and infectious disease testing (infections with soil-transmitted helminths, schistosomes, and Plasmodium). Individuals identified to have elevated blood pressure, glucose, lipids, or with infections were referred to the central/national health center for diagnostic confirmation and treatment. Aliquots of urine, stool, and venous blood were stored in a biobank for future exposome/phenome research. In-person interviews on sociodemographic attributes, risk factors for infectious diseases and NCDs, medication, vaccinations, and health care were also conducted. Appropriate statistical techniques will be applied in exploring the concomitance of infectious diseases and NCDs and their determinants. Participants’ consent for follow-up contact was obtained. RESULTS Key results from this baseline study, which will be published in peer-reviewed literature, will provide information on the prevalence and co-occurrence of infectious diseases, NCDs, and their risk factors. The Taabo HDSS consists of rural and somewhat more urbanized areas, allowing for comparative studies at different levels of epidemiological transition. An HDSS setting is ideal as a basis for longitudinal studies since their sustainable field work teams hold close contact with the local population. CONCLUSIONS The collaboration between research institutions, public health organizations, health care providers, and staff from the Taabo HDSS in this study assures that the synthesized evidence will feed into health policy towards integrated infectious disease-NCD management. The preparation of health systems for the dual burden of disease is pressing in low- and middle-income countries. The established biobank will strengthen the local research capacity and offer opportunities for biomarker studies to deepen the understanding of the cross-talk between infectious diseases and NCDs. CLINICALTRIAL International Standard Randomized Controlled Trials Number (ISRCTN): 87099939; http://www.isrctn.com/ISRCTN87099939 (Archived by WebCite at http://www.webcitation.org/6uLEs1EsX)

scholarly journals The epidemiological transition in Papua New Guinea: new evidence from verbal autopsy studies

2019 ◽  
Vol 48 (3) ◽  
pp. 966-977 ◽  
Author(s):  
Hebe N Gouda ◽  
Riley H Hazard ◽  
Seri Maraga ◽  
Abraham D Flaxman ◽  
Andrea Stewart ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Papua New Guinea ◽  
Causes Of Death ◽  
Emerging Infectious Diseases ◽  
New Guinea ◽  
Chronic Respiratory Disease ◽  
Service Planning ◽  
Epidemiological Transition ◽  
Emerging Infections ◽  
Endemic Infections

Abstract Background Recent economic growth in Papua New Guinea (PNG) would suggest that the country may be experiencing an epidemiological transition, characterized by a reduction in infectious diseases and a growing burden from non-communicable diseases (NCDs). However, data on cause-specific mortality in PNG are very sparse, and the extent of the transition within the country is poorly understood. Methods Mortality surveillance was established in four small populations across PNG: West Hiri in Central Province, Asaro Valley in Eastern Highlands Province, Hides in Hela Province and Karkar Island in Madang Province. Verbal autopsies (VAs) were conducted on all deaths identified, and causes of death were assigned by SmartVA and classified into five broad disease categories: endemic NCDs; emerging NCDs; endemic infections; emerging infections; and injuries. Results from previous PNG VA studies, using different VA methods and spanning the years 1970 to 2001, are also presented here. Results A total of 868 deaths among adolescents and adults were identified and assigned a cause of death. NCDs made up the majority of all deaths (40.4%), with the endemic NCD of chronic respiratory disease responsible for the largest proportion of deaths (10.5%), followed by the emerging NCD of diabetes (6.2%). Emerging infectious diseases outnumbered endemic infectious diseases (11.9% versus 9.5%). The distribution of causes of death differed across the four sites, with emerging NCDs and emerging infections highest at the site that is most socioeconomically developed, West Hiri. Comparing the 1970–2001 VA series with the present study suggests a large decrease in endemic infections. Conclusions Our results indicate immediate priorities for health service planning and for strengthening of vital registration systems, to more usefully serve the needs of health priority setting.

scholarly journals Life expectancy and mortality in 363 cities of Latin America

2021 ◽  
Author(s):  
Usama Bilal ◽  
◽  
Philipp Hessel ◽  
Carolina Perez-Ferrer ◽  
Yvonne L. Michael ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Latin America ◽  
Life Expectancy ◽  
Latin American ◽  
Causes Of Death ◽  
Urban Environments ◽  
Noncommunicable Diseases ◽  
Modifiable Factors ◽  
Specific Mortality ◽  
Latin American Countries

AbstractThe concept of a so-called urban advantage in health ignores the possibility of heterogeneity in health outcomes across cities. Using a harmonized dataset from the SALURBAL project, we describe variability and predictors of life expectancy and proportionate mortality in 363 cities across nine Latin American countries. Life expectancy differed substantially across cities within the same country. Cause-specific mortality also varied across cities, with some causes of death (unintentional and violent injuries and deaths) showing large variation within countries, whereas other causes of death (communicable, maternal, neonatal and nutritional, cancer, cardiovascular disease and other noncommunicable diseases) varied substantially between countries. In multivariable mixed models, higher levels of education, water access and sanitation and less overcrowding were associated with longer life expectancy, a relatively lower proportion of communicable, maternal, neonatal and nutritional deaths and a higher proportion of deaths from cancer, cardiovascular disease and other noncommunicable diseases. These results highlight considerable heterogeneity in life expectancy and causes of death across cities of Latin America, revealing modifiable factors that could be amenable to urban policies aimed toward improving urban health in Latin America and more generally in other urban environments.

scholarly journals Changing Patterns in Causes of Death in a Cohort of Injecting Drug Users, 1980-2001

2004 ◽  
Vol 164 (11) ◽  
pp. 1214 ◽  
Author(s):  
Lorraine Copeland ◽  
John Budd ◽  
J. Roy Robertson ◽  
Rob A. Elton
Keyword(s):  
Drug Users ◽  
Causes Of Death ◽  
Injecting Drug Users ◽  
Changing Patterns

scholarly journals Tuberculosis and HIV mortality in Russia

2020 ◽  
Vol 98 (6) ◽  
pp. 15-21
Author(s):  
E. B. Tsybikovа ◽  
I. M. Son ◽  
A. V. Vlаdimirov
Keyword(s):  
Mortality Rate ◽  
Infectious Diseases ◽  
Hiv Infection ◽  
Causes Of Death ◽  
Age Groups ◽  
Young Age ◽  
Federal State ◽  
Statistical Monitoring ◽  
Hiv Mortality ◽  
Leading Position

The objective: to study changes in the structure of mortality from tuberculosis and HIV infection in Russia from 2000 to 2017.Subjects and methods. The data of the Federal State Statistics Service on the mortality of the Russian population from tuberculosis and HIV infection (standardized ratio per 100,000 population) for 2000-2017 were studied. Data on the structure of patients with TB/HIV co-infection were obtained from Form no. 61 of the federal statistical monitoring for 2017.Results. In Russia, there has been a steady decrease in the mortality rate from tuberculosis, the value of which in 2017 reached 5.9 per 100,000 people. At the same time, the average values of the mortality rate from tuberculosis have shifted towards the older age groups reaching maximum values in the age group of 45 years and older. On the contrary, the analysis of mortality from HIV infection (2006-2017) detected its unprecedented increase from 1.6 to 12.6 per 100,000 population. The maximum concentration of mortality from HIV infection was observed in young age groups (35-44 years old). The increase in mortality from HIV infection was accompanied by a change in the structure of mortality from infectious diseases: the proportion of tuberculosis decreased from 79.1% (2000) to 27.4% (2017), and the proportion of HIV infection increased from 0.1% ( 2000) to 57.2% (2017). Currently, in Russia, mortality from HIV infection in young age groups has taken a leading position in the structure of causes of death from infectious diseases, displacing mortality from tuberculosis.

scholarly journals Causes of death in Serbia since the mid-20th century

Stanovnistvo ◽  
2012 ◽  
Vol 50 (1) ◽  
pp. 89-106
Author(s):  
Ivan Marinkovic
Keyword(s):  
Cardiovascular Diseases ◽  
Infectious Diseases ◽  
20Th Century ◽  
Cause Of Death ◽  
21St Century ◽  
Causes Of Death ◽  
Total Population ◽  
Total Mortality ◽  
Population Mortality ◽  
Circulatory Diseases

The structure of the leading causes of death in Serbia has considerably changed in the last half century. Diseases which presented the main threat to the population a few decades ago are now at the level of a statistical error. On the one side are causes which drastically changed their share in total mortality in this time interval, while others have shown stability and persistence among the basic causes of death. Acute infectious diseases "have been replaced" with chronic noninfectious diseases, due to the improvement of general and health conditions. One of the consequences of such changes is increased life expectancy and a larger share of older population which resulted in cardiovascular diseases and tumors to dominate more and more in total mortality. Convergent trends in the structure of the leading causes of death in Serbia from the middle of the 20th century are the reasons why there are considerably fewer diseases and causes with a significant rate in total population mortality at the beginning of the 21st century. During the 1950s, there were five groups of diseases and causes which participated individually with more than 10% of population mortality (infectious diseases, heart and circulatory diseases, respiratory diseases, some perinatal conditions and undefined states) while at the beginning of the new century there were only two such groups (cardiovascular diseases and tumors). Identical trends exist in all European countries, as well as in the rest of the developed world. The leading causes of death in Serbia are cardiovascular diseases. An average of somewhat over 57.000 people died annually in the period from 2007 - 2009, which represents 55.5% of total population mortality. Women are more numerous among the deceased and this difference is increasing due to population feminization. The most frequent cause of death in Serbia, after heart and circulatory diseases, are tumors, which caused 21,415 deaths in 2009. Neoplasms are responsible for one fifth of all deaths. Their number has doubled in three decades, from 9,107 in 1975 to about 20,000 at the beginning of the 21st century, whereby tumors have become the fastest growing cause of death. Least changes in absolute number of deaths in the last half century were marked among violent deaths. Observed by gender, men are in average three times more numerous among violent deaths than women. In the middle of the 20th century in Serbia, one third of the deaths caused by violence were younger than 25 and as many as one half were younger than 35 years old. Only one tenth (11%) of total number of violent deaths were from the age group of 65 or older. At the end of the first decade of the 21st century (2009), the share of population younger than 25 in the total number of violent deaths was decreased four times (and amounted to 8%). At the same time, the rate of those older than 65 or more quadrupled (amounted to 39%).

scholarly journals Causes of death in growing-finishing pigs in two technified farms in southern Brazil

2020 ◽  
Vol 40 (10) ◽  
pp. 758-775
Author(s):  
Manoela M. Piva ◽  
Claiton I. Schwertz ◽  
Ronaldo M. Bianchi ◽  
Regina T. Kemper ◽  
Luan Cleber Henker ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Influenza A ◽  
Pasteurella Multocida ◽  
Causes Of Death ◽  
Histopathological Examination ◽  
Gastric Ulcers ◽  
Finishing Pigs ◽  
Southern Brazil ◽  
Bacterial Pericarditis ◽  
Conclusive Diagnosis

ABSTRACT: The aim of this study was to investigate the main causes of death in growing-finishing pigs in southern Brazil. During a one-year period (from 2018 to 2019), two industrial pig herds (18 and 20 thousand pigs each farm) in southern Brazil were monitored along the four seasons of the year (12 days per season on each farm), in order to perform necropsies of all pigs that died in that period. The two farms had an average monthly mortality rate ranging from 0.94 to 3.93% in the evaluated months. At necropsy, tissues were collected, fixed in 10% formalin solution and processed routinely for histopathological examination. When necessary, samples were sent for bacterial culture and PCR to identify etiologic agents. A total of 601 necropsies were performed, with 94.9% of conclusive diagnoses. Infectious diseases corresponded to 64.4% of conclusive diagnosis and non-infectious diseases to 35.6%. The most prevalent causes of death were: pneumonia (33%), gastric ulcers (15.4%), circovirosis (9.9%), systemic bacterial embolism (5.4%), polyserositis (4.4%), dilated cardiomyopathy and torsion of abdominal organs (4.3% each), and bacterial pericarditis (3.4%). Regarding pneumonias (199/601), the main agents identified in these cases were Pasteurella multocida, Influenza A virus and Mycoplasma hyopneumoniae, mainly in associations.

Bacterial Infecfions: Changes in Their Causative Agents—Trends and Possible Basis (Bayer—Symposium III), edited by M. Finland, W. Marget, and K. Bartmann. New York/Heidelberg/Berlin: Springer-Verlag, 1971, 231 pp., $15.00

PEDIATRICS ◽  
1972 ◽  
Vol 50 (5) ◽  
pp. 833-833
Author(s):  
John D. Nelson
Keyword(s):  
United States ◽  
New York ◽  
Great Britain ◽  
Los Angeles ◽  
Infectious Diseases ◽  
Bacterial Infections ◽  
The United States ◽  
New Haven ◽  
Causative Agents ◽  
Changing Patterns

Almost two years ago a group of eminent international authorities in the field of infectious diseases gathered near Cologne, Germany, for a week of reflection and discussion concerning the changing patterns of bacterial infections in recent decades and the possible reasons for the changes. The United States was represented by Drs. M. Finland and E. H. Kass of Boston, F. Daschner of Los Angeles, and A. von Graevenitz of New Haven. Other scientists were from Germany, France, Sweden, Great Britain, Switzerland, and Denmark.

scholarly journals Update on TB Vaccine Pipeline

2020 ◽  
Vol 10 (7) ◽  
pp. 2632 ◽  
Author(s):  
Carlos Martin ◽  
Nacho Aguilo ◽  
Dessislava Marinova ◽  
Jesus Gonzalo-Asensio
Keyword(s):  
Drug Resistance ◽  
Clinical Trials ◽  
Mycobacterium Tuberculosis ◽  
Infectious Diseases ◽  
Significant Role ◽  
Causes Of Death ◽  
Multi Drug Resistance ◽  
Bacillus Calmette Guerin ◽  
The World

In addition to antibiotics, vaccination is considered among the most efficacious methods in the control and the potential eradication of infectious diseases. New safe and effective vaccines against tuberculosis (TB) could be a very important tool and are called to play a significant role in the fight against TB resistant to antimicrobials. Despite the extended use of the current TB vaccine Bacillus Calmette-Guérin (BCG), TB continues to be transmitted actively and continues to be one of the 10 most important causes of death in the world. In the last 20 years, different TB vaccines have entered clinical trials. In this paper, we review the current use of BCG and the diversity of vaccines in clinical trials and their possible indications. New TB vaccines capable of protecting against respiratory forms of the disease caused by sensitive or resistant Mycobacterium tuberculosis strains would be extremely useful tools helping to prevent the emergence of multi-drug resistance.

Substance Involvement and Physical Health

2014 ◽  
Author(s):  
Svetlana Popova ◽  
Jürgen Rehm
Keyword(s):  
Infectious Diseases ◽  
Heavy Drinking ◽  
Noncommunicable Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Moderate Drinking ◽  
Illegal Drug Use ◽  
Ischemic Disease ◽  
Substance Involvement ◽  
Include Lung Cancer

Substance use, mainly defined as the consumption of alcohol, tobacco, and illegal drugs, is a major risk factor for disease, disability, and mortality. Alcohol consumption can cause a number of chronic diseases, including several types of cancer, diseases of the gastrointestinal tract, various cardiovascular diseases, alcohol use disorders and infectious diseases, such as tuberculosis and pneumonia. Certain patterns of light moderate drinking, without heavy drinking occasions, may incur a protective effect on ischemic disease categories and diabetes. Finally, alcohol has been established as a causal factor for unintentional and intentional injury. Illegal drug use has been mainly linked to four health outcomes: overdose and other injury, noncommunicable diseases, certain mental disorders, and infectious diseases. In the final section, a comprehensive list of diseases attributable to tobacco smoking is provided, and the most important selected medical conditions are described. These include lung cancer, chronic obstructive pulmonary disease, and ischemic heart disease.

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