scholarly journals Computational Design and Lab-Based Investigation of a Novel Small-Molecule Inhibitor That Targets CadA Metal Efflux Pump Activity in Hospital Methicillin-Resistant Staphylococcus Aureus: A Research Protocol

2021 ◽  
Vol 5 (10) ◽  
pp. 1-11
Author(s):  
Jason Wang ◽  
David Chen ◽  
Lucus Wong ◽  
Eugene Chung
Keyword(s):  
Staphylococcus Aureus ◽  
Small Molecule ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Efflux Pump ◽  
Computational Design ◽  
Research Protocol ◽  
Methicillin Resistant ◽  
Molecule Inhibitor ◽  
Pump Activity ◽  
Metal Efflux

Frequency of efflux pump genes mediating ciprofloxacin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates

2017 ◽  
Vol 111 ◽  
pp. 71-74 ◽  
Author(s):  
Sepideh Hassanzadeh ◽  
Rahil Mashhadi ◽  
Masoud Yousefi ◽  
Emran Askari ◽  
Maryam Saniei ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Efflux Pump ◽  
Methicillin Resistant

scholarly journals Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

2016 ◽  
Vol 14 (28) ◽  
pp. 6853-6856 ◽  
Author(s):  
Matthew D. Stephens ◽  
Nisakorn Yodsanit ◽  
Christian Melander
Keyword(s):  
Staphylococcus Aureus ◽  
Small Molecule ◽  
Broad Spectrum ◽  
Biofilm Formation ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Small Molecule Library

A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethylN-(2-phenethyl) carbamate. From this library, a more potent, broad-spectrum inhibitor of MRSA biofilm formation was discovered.

scholarly journals Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus

2015 ◽  
Vol 23 (21) ◽  
pp. 7061-7068 ◽  
Author(s):  
Jinshan Jin ◽  
Jianmei Cui ◽  
Arpana Sagwal Chaudhary ◽  
Ying-Hsin Hsieh ◽  
Krishna Damera ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Small Molecule ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant

Efflux pump inhibitory activity of flavonoids isolated from Alpinia calcarata against methicillin-resistant Staphylococcus aureus

Biologia ◽  
2016 ◽  
Vol 71 (5) ◽  
Author(s):  
Harmandeep K. Randhawa ◽  
Kanwarpreet K. Hundal ◽  
Pallavi N. Ahirrao ◽  
Sanjay M. Jachak ◽  
Hemraj S. Nandanwar
Keyword(s):  
Staphylococcus Aureus ◽  
Inhibitory Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Efflux Pump ◽  
Methicillin Resistant

AbstractMethicillin-resistant

scholarly journals Dihydrostilbenes from Indigofera Pulchra

2008 ◽  
Vol 3 (5) ◽  
pp. 1934578X0800300
Author(s):  
Aliyu Musa ◽  
A. K. Haruna ◽  
M. Ilyas ◽  
Augustine Ahmadu ◽  
Simon Gibbons ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Nmr Spectroscopy ◽  
Structure Elucidation ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Efflux Pump ◽  
2D Nmr ◽  
Multidrug Resistant ◽  
Methicillin Resistant ◽  
Weak Activity

A mixture of two new dihydrostilbenes, 3-methoxy-4,5-methylenedioxy-4′- O-(2ξ,3-dihydroxy-3-methylbutyl)-dihydrostilbene (1) and 3,5-dimethoxy-4′- O-(2ξ,3-dihydroxy-3-methylbutyl)-dihydrostilbene (2), was isolated from Indigofera pulchra as an inseparable mixture. Several isolation strategies, including multiple preparative TLC, SPE and finally HPLC were undertaken in an attempt to separate these metabolites, but to no avail. Structure elucidation on the mixture was conducted and we were able to establish the structures of these compounds unambiguously by MS and a series of 1D and 2D-NMR analyses. The mixture of these dihydrostilbenes was analyzed by NMR spectroscopy and 1 and 2 were in a ratio of 52:48, respectively, and this was evaluated against a panel of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant variants of this organism, including a strain over-expressing the NorA efflux pump; weak activity was observed.

scholarly journals Recurrent Methicillin-Resistant Staphylococcus aureus Cutaneous Abscesses and Selection of Reduced Chlorhexidine Susceptibility during Chlorhexidine Use

2015 ◽  
Vol 53 (11) ◽  
pp. 3677-3682 ◽  
Author(s):  
Ryan C. Johnson ◽  
Carey D. Schlett ◽  
Katrina Crawford ◽  
Jeffrey B. Lanier ◽  
D. Scott Merrell ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Disease Prevention ◽  
Clinical Isolate ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Efflux Pump ◽  
Methicillin Resistant ◽  
Content Type ◽  
Selection Of

We describe the selection of reduced chlorhexidine susceptibility during chlorhexidine use in a patient with two episodes of cutaneous USA300 methicillin-resistantStaphylococcus aureusabscess. The second clinical isolate harbors a novel plasmid that encodes the QacA efflux pump. Greater use of chlorhexidine for disease prevention warrants surveillance for resistance.

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