Role of serum zinc levels in simple febrile convulsions in children

2019 ◽  
Vol 9 (1) ◽  
pp. 36-38
Author(s):  
S W Srikanth ◽  
◽  
Sharanagouda Patil ◽  
Rachapudi Venkata Anusha ◽  
◽  
...  
Keyword(s):  
Serum Zinc ◽  
Febrile Convulsions ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals A study of serum zinc levels in children with febrile convulsions in comparison with normal and febrile children

2020 ◽  
Vol 7 (3) ◽  
pp. 588
Author(s):  
Madhubalan T. ◽  
Chidambaranathan S. ◽  
Ramamoorthy R.
Keyword(s):  
Statistical Significance ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Normal Children ◽  
Febrile Convulsions ◽  
Significant Difference ◽  
Zinc Levels ◽  
The Brain ◽  
Serum Zinc Levels

Background: A seizure is a paroxysmal time-limited change in motor activity and or behavior that results from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain such as high fever, infection, syncope, head trauma, hypoxia, or toxins. To determine whether children with febrile convulsion have decreased serum zinc level when compared to normal children and children with fever without convulsions.Methods: The study included children admitted with bronchiolitis in between during the period of September 2018 to January 2019 at Department of Pediatrics, Raja Muthiah Medical College and Hospital. It is a case-control study. A sample size of 50 was selected for each group Totally 3 Groups, 1. Children with febrile convulsions,2. Children with fever without convulsions, 3. Normal Children.Results: The mean serum zinc level in children with febrile convulsions was 42.9 mcg/dl. The serum zinc level in children with fever and normal children was 70 mcg/dl and 71 mcg/dl respectively. On comparing the serum zinc level among the three groups statistical significance was obtained between children with febrile convulsions and the other two groups namely normal children and children with fever alone. Thus, decreased serum zinc level is a significant predisposing factor for febrile convulsions. By using Posthoc Multiple comparisons test we came to know that the Fever convulsion group is significantly different from fever and normal group. There is no significant difference between fever and normal group.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions, thus indicating that zinc deprivation plays a significant role in the pathogenesis of febrile convulsions.

scholarly journals Association between serum zinc level and simple febrile seizures in children: a hospital-based study

2018 ◽  
Vol 6 (9) ◽  
pp. 3116
Author(s):  
Najmus Saqib ◽  
Mahvish Qazi
Keyword(s):  
Hospital Admissions ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Chi Square ◽  
Febrile Convulsions ◽  
Female Ratio ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

scholarly journals A study of serum zinc levels among children with seizures in comparison with febrile children without seizures

2020 ◽  
Vol 7 (4) ◽  
pp. 876
Author(s):  
Pranam G. M. ◽  
Usha Hirevenkanagoudar ◽  
Sanjeev Chetty
Keyword(s):  
Neuronal Excitability ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Seizure Threshold ◽  
Febrile Convulsions ◽  
Pediatric Age Group ◽  
High Zinc ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Infants and children are more prone to have seizures than adults. This reflects the greater neuronal excitability at certain ages as the excitatory glutamate system and inhibitory GABA system do not always balance each other. Febrile seizures are the most common type of seizures observed in pediatric age group. Febrile seizures occur in young children at a time in their development when seizure threshold is low. Objective of the study was to determine the levels of zinc in children with febrile seizures when compared to children with fever without seizures.Methods: To determine the levels of zinc in children with febrile seizures when compared to children with fever without seizures. A total of 50 Study subjects were selected into each group. Group 1: Children with Febrile Seizures. Group 2: Children with Fever and Without Febrile Seizures.Results: Among the cases with fever and convulsion Zinc level was found to be low among 72% of the subjects, 22 % of them had normal zinc levels and only 6% had high zinc levels. Among the subjects with Fever and no convulsions nearly 80% of them had normal zinc levels, 16 % had low levels of zinc and 4% had high zinc levels. The association of levels of Zinc between both the groups was found to be statistically significant.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions when compared to children with fever alone without convulsions, thus indicating that zinc deprivation plays significant role in the pathogenesis of febrile convulsions.

Levels of Serum Zinc and Manganese among Post-Menopausal Patients with Thyroid Dysfunction

2016 ◽  
Vol 5 (02) ◽  
pp. 4821
Author(s):  
Sharique Ahmad* ◽  
Saeeda Wasim
Keyword(s):  
Thyroid Dysfunction ◽  
Serum Zinc ◽  
Flame Atomic Absorption ◽  
Flame Atomic Absorption Spectrophotometer ◽  
Serum Zn ◽  
Zinc Levels ◽  
Post Menopausal ◽  
Manganese Level ◽  
Serum Zinc Levels

The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism in Post-Menopausal Patients. The content of the trace elements Zinc and Manganese (Zn, and Mn) in the serum of patients was determined. Forty patients with hyperthyroidism and hypothyroidism were participated in this study. Serum zinc and manganese were determined using flame atomic absorption spectrophotometer technique. The study showed that serum zinc and manganese levels of hyperthyroidism patients were significantly lower (p<0.05). While a significant increase in serum manganese level with decrease serum zinc levels in patients with hypothyroidism (p<0.05).  The present study confirmed a significant change in the levels of serum Zn, Mn in hyperthyroidism and hypothyroidism among Post-Menopausal patients and these changes may be related to pathophysiology of thyroid disease.

scholarly journals A comparative study of serum zinc levels in children with febrile seizures and children with fever without seizures in an urban referral hospital

2018 ◽  
Vol 5 (3) ◽  
pp. 977 ◽  
Author(s):  
P. Sampathkumar ◽  
K. Suresh Kannan
Keyword(s):  
Zinc Deficiency ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Serum Levels ◽  
Predisposing Factor ◽  
Study Population ◽  
Zinc Levels ◽  
Group Serum ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children. However, the exact underlying etiology and the pathophysiological mechanisms are yet to be established. Various theories have been put forward regarding the role of trace elements as predisposing factors in causing the convulsions. Among them, Zinc is the most interesting trace element whose role in diarrhea and pneumonia is well proven. This study was done to know the correlation between zinc and febrile seizures, to estimate the serum levels of zinc in children with simple and complex febrile seizures and compare it with children with fever without seizures and to compare the levels of zinc in simple and complex febrile seizures.Methods: The study was conducted for a period of 6 months in the Department of Paediatrics, GMKMCH, and Salem. The study population included the children between 6 months to 6 years. During the study period 60 consecutive children with simple febrile seizures, 40 consecutive children with complex febrile seizures and 200 consecutive children with fever without seizures formed the study group. Serum zinc levels were measured in the three groups by using the calorimetric method.Results: The serum zinc levels were found to be low in 65% and 75% of children with simple and complex febrile seizures respectively. Only 20% of febrile children without convulsions had low zinc levels. Thus, a positive correlation was found between zinc deficiency and febrile convulsions.Conclusions: This study establishes a definite relationship between zinc deficiency and febrile seizures thereby substantiating zinc as an important predisposing factor in febrile seizures.

scholarly journals Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2077
Author(s):  
Jiun-Chi Huang ◽  
Ya-Chin Huang ◽  
Pei-Yu Wu ◽  
Wen-Hsien Lee ◽  
Yi-Chun Tsai ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Left Atrial Volume ◽  
Serum Zinc ◽  
Zinc Level ◽  
Volume Index ◽  
Serum Zinc Level ◽  
Lower Serum ◽  
Echocardiographic Parameters ◽  
Zinc Levels ◽  
Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

scholarly journals Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3187
Author(s):  
Tatsunori Toida ◽  
Reiko Toida ◽  
Shou Ebihara ◽  
Risa Takahashi ◽  
Hiroyuki Komatsu ◽  
...  
Keyword(s):  
Body Composition ◽  
Regression Analysis ◽  
Cardiovascular Events ◽  
Serum Zinc ◽  
Fluid Volume ◽  
The Body ◽  
All Cause Mortality ◽  
Cox's Regression ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45–59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox’s regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox’s regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.

Serum zinc levels in children with acute gastroenteritis

2007 ◽  
Vol 49 (3) ◽  
pp. 314-317 ◽  
Author(s):  
AKGÜN ÖLMEZ ◽  
S. SONGÜL YALÇIN ◽  
KADRIYE YURDAKÖK ◽  
TURGAY COSKUN
Keyword(s):  
Acute Gastroenteritis ◽  
Serum Zinc ◽  
Zinc Levels ◽  
Serum Zinc Levels

A Prospective Survey of Serial Maternal Serum Zinc Levels and Pregnancy Outcome

1988 ◽  
Vol 7 (3) ◽  
pp. 430-433 ◽  
Author(s):  
Akimasa Higashi ◽  
Akiko Tajiri ◽  
Makoto Matsukura ◽  
Ichiro Matsuda
Keyword(s):  
Pregnancy Outcome ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Prospective Survey ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Serum zinc levels in lung cancer patients

Cancer ◽  
1981 ◽  
Vol 47 (7) ◽  
pp. 1845-1848 ◽  
Author(s):  
Brian F. Issell ◽  
Bruce V. Macfadyen ◽  
Elizabeth T. Gum ◽  
Manuel Valdivieso ◽  
Stanley J. Dudrick ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Serum Zinc ◽  
Lung Cancer Patients ◽  
Zinc Levels ◽  
Serum Zinc Levels
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