Preclinical evaluation of hypolipidemic effect of hesperidin in high cholesterol diet model in wistar albino rats

2019 ◽  
Vol 10 (1) ◽  
pp. 05-08
Author(s):  
Pradeep Kumar V ◽  
◽  
Vijai Sundar E ◽  
Keyword(s):  
Albino Rats ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Preclinical Evaluation ◽  
Wistar Albino Rats ◽  
Diet Model

scholarly journals Anti-hyperlipidemic effect of crude methanolic extracts of Glycine max (soy bean) on high cholesterol diet-fed albino rats

2017 ◽  
pp. 1 ◽  
Author(s):  
Uchendu Kingsley ◽  
Onwukwe Steven ◽  
Chidozie Agu ◽  
Oliver Orji ◽  
Blessing Chekwube ◽  
...  
Keyword(s):  
Glycine Max ◽  
Albino Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Methanolic Extracts

scholarly journals Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Xu Tao ◽  
Peng Jing-bo ◽  
Zhang Wen-tong ◽  
Zhao Xin ◽  
Zhang Tao-tao ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Myocardial Ischemia ◽  
Probable Mechanism ◽  
High Cholesterol Diet ◽  
Standard Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Diet Model

Including herbal medicine, complementary and alternative medicine (CAM) is popular worldwide. The traditional Chinese medicine xinkeshu has been widely used to treat coronary heart disease in China. This study was designed to investigate the protective effect and probable mechanism of xinkeshu tablet to atherosclerotic myocardial ischemia rabbit. Rabbits were divided into four groups (n=12each) and fed with different diet for 12 weeks: Control (standard diet), Model (high-cholesterol diet), XKS (high-cholesterol diet with 184.8 mg/kg/d xinkeshu), and Atorvastatin (high-cholesterol diet with 5.0 mg/kg/d atorvastatin). Plasma lipoprotein, ECG, endothelium-dependent vessel relaxation, histomorphological study, and expressions of eNOS and VCAM-1 on coronary arteries were assessed. The findings showed that, similar to atorvastatin, xinkeshu presented significant effects on rescuing endothelium-dependent vessel relaxation, inhibiting atherosclerotic progress, preventing myocardial ischemia, and changing eNOS and VCAM-1 expression. However, xinkeshu showed no lipoprotein lowering effect in hypercholesterolemia rabbits. The results of the present study indicated that xinkeshu exerted potent antiatherogenic and anti-ischemic properties on atherosclerotic myocardial ischemia rabbit. An endothelial protecting effect may be involved in the mechanism other than antihyperlipidemic effect.

scholarly journals Hypolipidemic Effect of Tomato Juice in Hamsters in High Cholesterol Diet-Induced Hyperlipidemia

Nutrients ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 10525-10537 ◽  
Author(s):  
Li-Chen Lee ◽  
Li Wei ◽  
Wen-Ching Huang ◽  
Yi-Ju Hsu ◽  
Yi-Ming Chen ◽  
...  
Keyword(s):  
Tomato Juice ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals Rutin Supplementation on Cholesterol Metabolism in Female Albino Wistar Rats Using High‐Cholesterol‐Diet Model: Possible Renal Protection

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
SALIM S. AL-REJAIE ◽  
Hatem M. Abuohashish ◽  
Abdulaziz S. Alroujayee ◽  
Abdulaziz M. Aleisa ◽  
Osama Alkhamees
Keyword(s):  
Wistar Rats ◽  
Cholesterol Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Renal Protection ◽  
Diet Model

scholarly journals PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL

Biomedika ◽  
2013 ◽  
Vol 5 (2) ◽  
Author(s):  
. Muhtadi ◽  
. Haryoto ◽  
Tanti Azizah Sujono ◽  
Peni Indaryudha ◽  
Andi Suhendi
Keyword(s):  
Ethanolic Extract ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Control Group Design ◽  
Group I ◽  
Nephelium Lappaceum

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet

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