scholarly journals Hypolipidemic Effect of Tomato Juice in Hamsters in High Cholesterol Diet-Induced Hyperlipidemia

Nutrients ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 10525-10537 ◽  
Author(s):  
Li-Chen Lee ◽  
Li Wei ◽  
Wen-Ching Huang ◽  
Yi-Ju Hsu ◽  
Yi-Ming Chen ◽  
...  
Keyword(s):  
Tomato Juice ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL

Biomedika ◽  
2013 ◽  
Vol 5 (2) ◽  
Author(s):  
. Muhtadi ◽  
. Haryoto ◽  
Tanti Azizah Sujono ◽  
Peni Indaryudha ◽  
Andi Suhendi
Keyword(s):  
Ethanolic Extract ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Control Group Design ◽  
Group I ◽  
Nephelium Lappaceum

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet

scholarly journals Hypolipidemic Effect of Mulberry Leaf Extract in Rats Fed a High-cholesterol Diet (P06-014-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yoonjin Lee ◽  
Eunyoung Lee ◽  
Mak-Soon Lee ◽  
Soojin Lee ◽  
Chaemin Kim ◽  
...  
Keyword(s):  
Bile Acid ◽  
Hydrostatic Pressure ◽  
High Hydrostatic Pressure ◽  
Density Lipoprotein ◽  
Acid Synthesis ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Mulberry Leaf

Abstract Objectives The purpose of this study was to evaluate the hypolipidemic effect of high hydrostatic pressure extract of mulberry leaf on in rats fed a high-cholesterol diet. Methods Male Sprague-Dawley rats were randomly allocated into four groups. Each group fed a normal diet (NOR), a high-cholesterol diet (HC), a HC containing 0.5% high hydrostatic pressure extract of mulberry leaves (ML), or a HC containing 1.0% high hydrostatic pressure extract of mulberry leaves (MH) for 4 weeks. Results Body weight and food intake were not different among the four groups. The levels of serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and atherosclerotic index (AI) significantly reduced in the ML and MH groups compared to HC group. While, in MH group, serum high-density lipoprotein cholesterol (HDL-C) was increased compared to HC group. Liver cholesterol was lower in the ML and MH groups than those in the HC group. Fecal excretion of the total lipid, TG, TC, and bile acid were higher in the ML and MH groups than those in the HC group. The mRNA related to cholesterol efflux and hepatic bile acid synthesis in liver, such as liver X receptor-a (LXRa), ATP-binding cassette sub-family G member 5(ABCG5), ATP-binding cassette sub-family G member 8 (ABCG8), and cholesterol 7- alpha hydroxylase gene (CYP7A1) were significantly upregulated in MH group compared to HC group. Conclusions These results suggest that hypolipidemic effect of mulberry leaf extracts partially associated with modulating gene expression related to hepatic cholesterol efflux, hepatic bile acid synthesis, and increasing fecal lipid excretion. Funding Sources None.

Anti-hyperlipidemic activity of an extract from roots and rhizomes of Panicum repens L. on high cholesterol diet-induced hyperlipidemia in rats

2015 ◽  
Vol 70 (5-6) ◽  
pp. 139-144 ◽  
Author(s):  
Walid Hamdy El-Tantawy ◽  
Abeer Temraz ◽  
Hoda E. Hozaien ◽  
Omayma D. El-Gindi ◽  
Kamilia F. Taha
Keyword(s):  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
Total Lipids ◽  
High Cholesterol ◽  
Panicum Repens

Abstract The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses of 250 mg/kg/day together with cholesterol at a dose of 100 mg/kg/day for 7 weeks. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. Administration of the P. repens extract (p<0.05) significantly reduced the rise of the serum levels of total lipids, TC, TG, and LDL-C, as well as the atherogenic index, whereas it significantly increased (p<0.05) the level of HDL-C. HPLC analysis of the phenolics and flavonoids in the extract revealed the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin. In conclusion, the P. repens extract was found to possess hypolipidemic activity in high-fat, diet-induced hyperlipidemic rats.

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