In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen

2016 ◽  
Vol 77 (2) ◽  
pp. 174-185 ◽  
Author(s):  
Jillian M. Haines ◽  
John M. Thomason ◽  
Eileen C. Seage ◽  
Robert W. Wills ◽  
Camilo Bulla ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Healthy Dogs ◽  
In Vivo Assessment

scholarly journals Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin

2012 ◽  
Vol 27 (1) ◽  
pp. 141-149 ◽  
Author(s):  
A. Dudley ◽  
J. Thomason ◽  
S. Fritz ◽  
J. Grady ◽  
J. Stokes ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Healthy Dogs

Investigation of the Interaction of Blood Platelets with the Coagulation System at the Site of Plug Formation In Vivo in Man - Effect of Low-Dose Aspirin

1987 ◽  
Vol 57 (01) ◽  
pp. 062-066 ◽  
Author(s):  
P A Kyrle ◽  
J Westwick ◽  
M F Scully ◽  
V V Kakkar ◽  
G P Lewis
Keyword(s):  
Platelet Activation ◽  
Thrombin Generation ◽  
Low Dose ◽  
Bleeding Time ◽  
Blood Platelets ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Plug Formation ◽  
Granule Release

SummaryIn 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, α-granule release (represented by β-thromboglobulin [βTG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug formation, considerable platelet activation and thrombin generation were seen within the first minute, as indicated by a 110-fold, 50-fold and 30-fold increase of FPA, TxB2 and PTG over the corresponding plasma values. After a further increase of the markers in the subsequent 3 minutes, they reached a plateau during the fourth and fifth minute. A low-dose aspirin regimen (0.42 mg.kg-1.day-1 for 7 days) caused >90% inhibition of TxB2formation in both bleeding time blood and clotted blood. At the site of plug formation, a-granule release was substantially reduced within the first three minutes and thrombin generation was similarly inhibited. We conclude that (a) marked platelet activation and considerable thrombin generation occur in the early stages.of haemostasis, (b) α-granule release in vivo is partially dependent upon cyclo-oxygenase-controlled mechanisms and (c) thrombin generation at the site of plug formation is promoted by the activation of platelets.

Increased Thromboxane Biosynthesis in Essential Thrombocythemia

1995 ◽  
Vol 74 (05) ◽  
pp. 1225-1230 ◽  
Author(s):  
Bianca Rocca ◽  
Giovanni Ciabattoni ◽  
Raffaele Tartaglione ◽  
Sergio Cortelazzo ◽  
Tiziano Barbui ◽  
...  
Keyword(s):  
Platelet Count ◽  
Platelet Activation ◽  
Essential Thrombocythemia ◽  
Therapeutic Strategy ◽  
Low Dose ◽  
Thrombotic Risk ◽  
Dose Aspirin ◽  
Gender And Age ◽  
Low Dose Aspirin

SummaryIn order to investigate the in vivo thromboxane (TX) biosynthesis in essential thromboeythemia (ET), we measured the urinary exeretion of the major enzymatic metabolites of TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 in 40 ET patients as well as in 26 gender- and age-matched controls. Urinary 11-dehydro-TXB2 was significantly higher (p <0.001) in thrombocythemic patients (4,063 ± 3,408 pg/mg creatinine; mean ± SD) than in controls (504 ± 267 pg/mg creatinine), with 34 patients (85%) having 11-dehydro-TXB2 >2 SD above the control mean. Patients with platelet number <1,000 × 109/1 (n = 25) had significantly higher (p <0.05) 11 -dehydro-TXB2 excretion than patients with higher platelet count (4,765 ± 3,870 pg/mg creatinine, n = 25, versus 2,279 ± 1,874 pg/mg creatinine, n = 15). Average excretion values of patients aging >55 was significantly higher than in the younger group (4,784 ± 3,948 pg/mg creatinine, n = 24, versus 2,405 ± 1,885 pg/mg creatinine, n = 16, p <0.05). Low-dose aspirin (50 mg/d for 7 days) largely suppressed 11-dehydro-TXB2 excretion in 7 thrombocythemic patients, thus suggesting that platelets were the main source of enhanced TXA2 biosynthesis. The platelet count-corrected 11-dehydro-TXB2 excretion was positively correlated with age (r = 0.325, n = 40, p <0.05) and inversely correlated with platelet count (r = -0.381, n = 40, p <0.05). In addition 11 out of 13 (85%) patients having increased count-corrected 11-dehydro-TXB2 excretion, belonged to the subgroup with age >55 and platelet count <1,000 × 1099/1. We conclude that in essential thrombocythemia: 1) enhanced 11-dehydro-TXB2 excretion largely reflects platelet activation in vivo;2) age as well as platelet count appear to influence the determinants of platelet activation in this setting, and can help in assessing the thrombotic risk and therapeutic strategy in individual patients.

Selective inhibition of thromboxane-related platelet function by low-dose aspirin in patients after myocardial infarction

1985 ◽  
Vol 55 (5) ◽  
pp. 589-590 ◽  
Author(s):  
Raffaele De Caterina ◽  
Daniela Giannessi ◽  
Walter Bernini ◽  
Paolo Gazzetti ◽  
Claudio Michelassi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Platelet Function ◽  
Low Dose ◽  
Selective Inhibition ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans

2012 ◽  
Vol 87 (4-5) ◽  
pp. 143-151 ◽  
Author(s):  
Robert C. Block ◽  
Lisa Kakinami ◽  
Matthew Jonovich ◽  
Illena Antonetti ◽  
Peter Lawrence ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Healthy Humans ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Aspirin Ingestion

scholarly journals Lower incidence of hypertensive complications during pregnancy in patients treated with low-dose aspirin during in vitro fertilization and early pregnancy

2009 ◽  
Vol 24 (10) ◽  
pp. 2447-2450 ◽  
Author(s):  
M. J. Lambers ◽  
E. Groeneveld ◽  
D. A. Hoozemans ◽  
R. Schats ◽  
R. Homburg ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Early Pregnancy ◽  
Lower Incidence ◽  
Low Dose ◽  
Vitro Fertilization ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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