In vitro bleeding test ? a sensitive method for the detection of platelet function impairment and a potential test for the control of low-dose aspirin efficacy

1989 ◽  
Vol 59 (2) ◽  
pp. 188-188 ◽  
Author(s):  
V. Kretschmer ◽  
B. Schikor ◽  
D. Soehngen ◽  
G. Dietrich
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Function Impairment ◽  
Potential Test ◽  
Sensitive Method

In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen

2016 ◽  
Vol 77 (2) ◽  
pp. 174-185 ◽  
Author(s):  
Jillian M. Haines ◽  
John M. Thomason ◽  
Eileen C. Seage ◽  
Robert W. Wills ◽  
Camilo Bulla ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Healthy Dogs ◽  
In Vivo Assessment

Selective inhibition of thromboxane-related platelet function by low-dose aspirin in patients after myocardial infarction

1985 ◽  
Vol 55 (5) ◽  
pp. 589-590 ◽  
Author(s):  
Raffaele De Caterina ◽  
Daniela Giannessi ◽  
Walter Bernini ◽  
Paolo Gazzetti ◽  
Claudio Michelassi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Platelet Function ◽  
Low Dose ◽  
Selective Inhibition ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans

2012 ◽  
Vol 87 (4-5) ◽  
pp. 143-151 ◽  
Author(s):  
Robert C. Block ◽  
Lisa Kakinami ◽  
Matthew Jonovich ◽  
Illena Antonetti ◽  
Peter Lawrence ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Healthy Humans ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Aspirin Ingestion

scholarly journals Lower incidence of hypertensive complications during pregnancy in patients treated with low-dose aspirin during in vitro fertilization and early pregnancy

2009 ◽  
Vol 24 (10) ◽  
pp. 2447-2450 ◽  
Author(s):  
M. J. Lambers ◽  
E. Groeneveld ◽  
D. A. Hoozemans ◽  
R. Schats ◽  
R. Homburg ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Early Pregnancy ◽  
Lower Incidence ◽  
Low Dose ◽  
Vitro Fertilization ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin

2009 ◽  
Vol 101 (04) ◽  
pp. 687-690 ◽  
Author(s):  
Caterina Pettinella ◽  
Mario Romano ◽  
Liborio Stuppia ◽  
Francesca Santilli ◽  
Rossella Liani ◽  
...  
Keyword(s):  
Low Dose ◽  
Ex Vivo ◽  
Aspirin Resistance ◽  
Platelet Response ◽  
Dose Aspirin ◽  
Cyclooxygenase 1 ◽  
Low Dose Aspirin ◽  
Induced Aggregation ◽  
Cox 1

SummaryCOX-1 polymorphism C50T, in complete linkage disequilibrium with the other polymorphism A-842G, has been depicted as a determinant of pharmacological response to aspirin treatment. Whether these polymorphisms exert an effect on response to aspirin both in vitro and ex vivo is still controversial. We geno-typed a population of 148 healthy individuals for the C50T/A-842G haplotype. Thirty of them underwent low-dose aspirin (100 mg daily) treatment for four weeks and were followed up for seven days after withdrawal. In this subgroup, we evaluated the thromboxane-dependence of biochemical and functional indexes used to monitor the antiplatelet effect of low-dose aspirin. Among the 148 subjects studied, 10 were heterozygous for the C50T/A-842G haplotype (6.7%) and only one was homozygous for the 50T/-842G haplotype (0.67%). In the group on low-dose aspirin, serum thromboxane (TX) B2 as well as urinary 11-dehydro-TXB2 and arachidonic acid (AA)-induced aggregation were similarly suppressed in carriers and non-carriers of the 50T/-842G haplotype, with an increase until basal levels of all the parameters within seven days after withdrawal. We found no relationship between the 50T/-842G haplotype and the so-called phenomenon of aspirin resistance. Platelet cyclooxygenase activity, as reflected by serum TXB2, was uniformly and persistently suppressed by low-dose aspirin in both carriers and non carriers of these polymorphisms.

Lower incidence of vascular complications during pregnancy in women treated with low dose aspirin in in-vitro-fertilisation (IVF)

2008 ◽  
Vol 90 ◽  
pp. S211
Author(s):  
M.J. Lambers ◽  
E. Groeneveld ◽  
D.A. Hoozemans ◽  
R. Schats ◽  
C.B. Lambalk ◽  
...  
Keyword(s):  
Lower Incidence ◽  
Low Dose ◽  
Vascular Complications ◽  
In Vitro Fertilisation ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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