scholarly journals The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans

2012 ◽  
Vol 87 (4-5) ◽  
pp. 143-151 ◽  
Author(s):  
Robert C. Block ◽  
Lisa Kakinami ◽  
Matthew Jonovich ◽  
Illena Antonetti ◽  
Peter Lawrence ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Healthy Humans ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Aspirin Ingestion

scholarly journals Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans

2009 ◽  
Vol 106 (2) ◽  
pp. 500-505 ◽  
Author(s):  
Lacy A. Holowatz ◽  
W. Larry Kenney
Keyword(s):  
Low Dose ◽  
Aspirin Therapy ◽  
Oral Temperature ◽  
Middle Aged ◽  
Doppler Flowmetry ◽  
Healthy Humans ◽  
Cutaneous Vasodilation ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Reflex Cutaneous Vasodilation

Full expression of reflex cutaneous vasodilation is dependent on cyclooxygenase- (COX) and nitric oxide synthase- (NOS) dependent mechanisms. Low-dose aspirin therapy is widely prescribed to inhibit COX-1 in platelets for atherothrombotic prevention. We hypothesized that chronic COX inhibition with daily low-dose aspirin therapy (81 mg) would attenuate reflex vasodilation in healthy human skin. Two microdialysis fibers were placed in forearm skin of seven middle-aged (57 ± 3 yr), normotensive, healthy humans with no preexisting cardiovascular disease, taking daily low-dose aspirin therapy (aspirin: 81 mg), and seven unmedicated, healthy, age-matched control (no aspirin, 55 ± 3 yr) subjects, with one site serving as a control (Ringer) and the other NOS inhibited (NOS inhibited: 10 mM NG-nitro-l-arginine methyl ester). Red cell flux was measured over each site by laser-Doppler flowmetry, as reflex vasodilation was induced by increasing core temperature (oral temperature) 1.0°C using a water-perfused suit. Cutaneous vascular conductance (CVC) was calculated (CVC = flux/mean arterial pressure) and normalized to maximal CVC (CVCmax; 28 mM sodium nitroprusside). CVCmax was not affected by either aspirin or NOS inhibition. The plateau in cutaneous vasodilation during heating (change in oral temperature = 1.0°C) was significantly attenuated in the aspirin group (aspirin: 25 ± 3% CVCmax vs. no aspirin: 50 ± 7% CVCmax, P < 0.001 between groups). NOS inhibition significantly attenuated %CVCmax in both groups (aspirin: 17 ± 2% CVCmax, no aspirin: 23 ± 3% CVCmax; P < 0.001 vs. control), but this attenuation was less in the no-aspirin treatment group ( P < 0.001). This is the first observation that chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation through both COX- and NOS-dependent mechanisms.

Selective inhibition of thromboxane-related platelet function by low-dose aspirin in patients after myocardial infarction

1985 ◽  
Vol 55 (5) ◽  
pp. 589-590 ◽  
Author(s):  
Raffaele De Caterina ◽  
Daniela Giannessi ◽  
Walter Bernini ◽  
Paolo Gazzetti ◽  
Claudio Michelassi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Platelet Function ◽  
Low Dose ◽  
Selective Inhibition ◽  
Dose Aspirin ◽  
Low Dose Aspirin

In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen

2016 ◽  
Vol 77 (2) ◽  
pp. 174-185 ◽  
Author(s):  
Jillian M. Haines ◽  
John M. Thomason ◽  
Eileen C. Seage ◽  
Robert W. Wills ◽  
Camilo Bulla ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Healthy Dogs ◽  
In Vivo Assessment

Effects of enteric-coated, low-dose aspirin on parameters of platelet function

2002 ◽  
Vol 16 (9) ◽  
pp. 1683-1688 ◽  
Author(s):  
A. Van Hecken ◽  
M. L. Juliano ◽  
M. Depré ◽  
I. De Lepeleire ◽  
J. Arnout ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Enteric Coated

scholarly journals Platelet Cyclooxygenase Inhibition by Low-Dose Aspirin Is Not Reflected Consistently by Platelet Function Assays

2009 ◽  
Vol 53 (8) ◽  
pp. 667-677 ◽  
Author(s):  
Francesca Santilli ◽  
Bianca Rocca ◽  
Raimondo De Cristofaro ◽  
Stefano Lattanzio ◽  
Laura Pietrangelo ◽  
...  
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Cyclooxygenase Inhibition ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Platelet Function Assays

Effects of oral diltiazem on platelet function: alone and in combination with “low dose” aspirin

1986 ◽  
Vol 44 (3) ◽  
pp. 391-400 ◽  
Author(s):  
Michael E. Ring ◽  
James J. Corrigan ◽  
Paul E. Fenster
Keyword(s):  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals Use of the platelet function analyser (PFA-100R) to quantify the effect of low dose aspirin in patients with ischaemic heart disease

Anaesthesia ◽  
2005 ◽  
Vol 60 (12) ◽  
pp. 1173-1178 ◽  
Author(s):  
M. Coakley ◽  
R. Self ◽  
W. Marchant ◽  
I. Mackie ◽  
S. V. Mallett ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Platelet Function ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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