scholarly journals A STUDY ON GLYCATED HEMOGLOBIN IN RELATION TO SERUM ALKALINE PHOSPHATASE, C REACTIVE PROTEIN AND LIPID PROFILE IN TYPE II DIABETES MELLITUS

2019 ◽  
Vol 6 (2) ◽  
pp. 47-56
Author(s):  
S. Mohd. Shiraz Rizvi ◽  
Roshan Alam ◽  
Saba Khan ◽  
Jyoti Verma ◽  
Farzana Mahdi
Keyword(s):  
Diabetes Mellitus ◽  
Alkaline Phosphatase ◽  
Lipid Profile ◽  
Type Ii Diabetes ◽  
Glycated Hemoglobin ◽  
Serum Alkaline Phosphatase ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγ/eNOS Signaling Pathway

PPAR Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hua Guo ◽  
Qinglan Zhang ◽  
Haipo Yuan ◽  
Lin Zhou ◽  
Fang-fang Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Hepg2 Cells ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
C Reactive Protein ◽  
No Donor ◽  
Reactive Protein ◽  
Tnf Α

Inflammation accounts for the process of type II diabetes mellitus (T2DM), the specific mechanism of which is still to be elucidated yet. Nitric oxide (NO), a critical inflammation regulator, the role of which is the inflammation of T2DM, is rarely reported. Therefore, our study is aimed at exploring the effect of NO on the inflammation in T2DM and the corresponding mechanism. We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1β, TNF-α, IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPARγ, eNOS, C-reactive protein, heptoglobin, IL-1β, TNF-α, and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPARγ. The results showed that excess NO increased the inflammation marker levels in T2DM, which is activated by the PPARγ/eNOS pathway. These findings will strengthen the understanding of NO in T2DM and provide a new target for the treatment of T2DM.

INFLUENCE OF THIOCTIC ACID N LABORATORY INDICATORS OF CARBOHYDRATE EXCHANGE IN PATIENTS WITH TYPE II DIABETES MELLITUS

2021 ◽  
pp. 29-35
Author(s):  
Kim V.S. ◽  
Abramova A.N. ◽  
Shur Yu.V. ◽  
Selezneva T.E. ◽  
Tsibizova A.A. ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Type Ii Diabetes ◽  
Glycated Hemoglobin ◽  
Type Ii Diabetes Mellitus ◽  
Metformin Hydrochloride ◽  
Thioctic Acid ◽  
Type Ii ◽  
Hypoglycemic Agent ◽  
Normal Body Weight

The work is devoted to assessing the effect of thioctic acid on the main laboratory parameters of carbohydrate metabolism (blood glucose, C-peptide and insulin levels, glycated hemoglobin) in diabetes mellitus against the background of glucose-lowering therapy with metformin hydrochloride. The studies were conducted with the participation of 32 volunteers aged 52 to 63 years, 26 of whom type II diabetes mellitus proceeded with III-degree obesity. At the time of the study, all patients were taking metformin hydrochloride (MH) as a hypoglycemic agent. The experiment was carried out for 3 months. All study participants were divided into groups: the first group - the control group, who took only MG 850 mg once a day for; the second group, patients with normal body weight, who took metformin hydrochloride 850 mg and thioctic acid (TA) 600 mg per day; the third group - obese patients receiving the test compound at the same dosage. After 3 months of treatment, all patients underwent biochemical blood tests for the following parameters: blood glucose, glycated hemoglobin, C-peptide and insulin levels. The results obtained indicate that thioctic acid contributed to a more pronounced decrease in carbohydrate metabolism in comparison with the group of patients receiving only MH as a hypoglycemic agent. It was noted that the normalization of the studied parameters was expressed in the group of patients with normal body weight. Thus, the additional introduction of thioctic acid into the treatment regimen for patients with type II diabetes mellitus contributes to a more effective decrease in carbohydrate metabolism and compensation of the disease in comparison with standard therapy.

Clinical Study of Ultrasonic Extreme Velocity Imaging Pulse Wave Technique in Carotid Elasticity in Patients with Type II Diabetes Mellitus

2021 ◽  
Vol 11 (6) ◽  
pp. 1138-1143
Author(s):  
Fang Ma ◽  
Jimei Xu ◽  
Weiwei Yang ◽  
Fuqin Bian
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Type Ii Diabetes ◽  
Pulse Wave ◽  
Glycated Hemoglobin ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Carotid Imt ◽  
Wave Technology ◽  
Biochemical Indices

In this study, extreme velocity ultrasonic imaging pulse wave technology was used to detect the main indices of atherosclerosis such as carotid intima-media thickness (IMT) and carotid elasticity, and biochemical indices such as glycated hemoglobin, blood glucose and blood lipids in one hundred twenty 18–60-year-old patients with type II diabetes mellitus (T2DM) and 120 healthy controls. We analyzed the correlations between carotid elasticity, carotid IMT, and a range of biochemical indices. The results indicated that when the carotid IMT in young and middle-aged patients with T2DM was within the normal range (0.56±0.03 mm), the carotid artery elasticity was abnormal [Pulse wave propagation velocity (PWV)-BS = 7.69± 1.26 m/s; PWV-ES = 8.34±1.51 m/s; P < 0.05]. Additionally, PWV-BS was positively correlated with age, course of the disease, glycated hemoglobin (HbA1c), and fasting blood glucose (FBG) (r = 0.297, 0.377, 0.369, 0.382), and PWV-ES was positively correlated with age, course of the disease, HbA1c, and FBG (r = 0.318, 0.386, 0.392, 0.339). This finding provides a basis for extreme velocity ultrasonic imaging pulse wave technology to become a new method for the early screening of atherosclerosis in patients with T2DM; this is important for timely clinical intervention in patients with T2DM.

scholarly journals MICROALBUMINEMIA;

2017 ◽  
Vol 24 (03) ◽  
pp. 478-481
Author(s):  
Muhammad Mahboob Alam ◽  
Muhammad Akhtar Parvez ◽  
Muhammad Murtaza
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii

Objective: to determine the frequency of microalbuminemia in type IIdiabetic patients and to compare lipid profile in type II diabetic patients with and withoutmicroalbuminuria. Settings: Department of Medicine, Allied Hospital, Faisalabad. Durationof study: From: January 2015 to December 2015. Results: In our study, mean age was53.18+9.32 years, 43.90% (n=151) were male and 56.10% (n=193) were females, frequencyof microalbuminuria in type II diabetes mellitus was recorded in 32.56%(n=112). Conclusion:the frequency of microalbuminemia in type II diabetic patients is higher while the frequencyof hypertriglyceridemias, increased LDL-C and decreased HDL-C in Type II diabetic patientsis significantly higher in patients with microalbuminuria when compared them withoutmicroalbuminuria..

A Study of Fasting and Postprandial Lipid Profile in Patients with Type II Diabetes Mellitus

2019 ◽  
Vol 10 (2) ◽  
pp. 59-61
Author(s):  
Nilima Deshpande ◽  
◽  
Gajanan Halkanche ◽  
Vishal Patil ◽  
Rajaram Power ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Postprandial Lipid
Sign in / Sign up

Export Citation Format

Share Document