scholarly journals Comparative Effects of Glibenclamide and Metformin on C-Reactive Protein and Oxidant - Antioxidant Status in Patients with Type II Diabetes Mellitus

2012 ◽  
Vol 12 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Alaa A. A. Abdulkadir ◽  
Imad A. J. Thanoon
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Antioxidant Status ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγ/eNOS Signaling Pathway

PPAR Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hua Guo ◽  
Qinglan Zhang ◽  
Haipo Yuan ◽  
Lin Zhou ◽  
Fang-fang Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Hepg2 Cells ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
C Reactive Protein ◽  
No Donor ◽  
Reactive Protein ◽  
Tnf Α

Inflammation accounts for the process of type II diabetes mellitus (T2DM), the specific mechanism of which is still to be elucidated yet. Nitric oxide (NO), a critical inflammation regulator, the role of which is the inflammation of T2DM, is rarely reported. Therefore, our study is aimed at exploring the effect of NO on the inflammation in T2DM and the corresponding mechanism. We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1β, TNF-α, IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPARγ, eNOS, C-reactive protein, heptoglobin, IL-1β, TNF-α, and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPARγ. The results showed that excess NO increased the inflammation marker levels in T2DM, which is activated by the PPARγ/eNOS pathway. These findings will strengthen the understanding of NO in T2DM and provide a new target for the treatment of T2DM.

scholarly journals Antioxidant status in type ii diabetes mellitus patients with or without microvascular complications

2007 ◽  
Vol 135 (3-4) ◽  
pp. 143-146 ◽  
Author(s):  
Nada Kostic ◽  
Zorica Caparevic ◽  
Sanja Ilic
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Antioxidant Status ◽  
Ldl Cholesterol ◽  
Type Ii Diabetes Mellitus ◽  
Antioxidant Systems ◽  
Diabetic Patients ◽  
Compensatory Mechanism ◽  
Type Ii ◽  
Pai 1

Introduction. Lipid peroxidation and antioxidant systems are important factors affecting the metabolism of lipoproteins in diabetes mellitus. Objective. The aim of this study was to investigate the lipid and antioxidant parameters in type II diabetes mellitus patients, and also to determine the effect of diabetic complications on these parameters. Method. Lipid status, Oxidized LDL cholesterol, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and plasminogen activator inhibitor (PAI-1) levels in plasma of 50 type II diabetic patients were measured with commercially available kits. Results. The results showed only statistically significant higher levels of triglycerides (3.12?3.9 mmol/l) in diabetics compared with the controls. Ox-LDL cholesterol (84.7?16.9 mmol/l) and SOD activities (913.4?120.3 U/gHb) in type 2 diabetes mellitus were higher than those of the controls, but there was no statistical significance. On the other hand, in patients with diabetes mellitus and complications, LDL cholesterol, PAI-1, SOD and GSH-Px activities were higher but not significantly than those without complications. Triglycerides and Ox-LDL cholesterol were lower in the group of diabetic patients with complications in comparison to the group without complications. Conclusion. These results indicate that antioxidant status may be affected in type II diabetic patients and that the rise in some enzyme activities could be a compensatory mechanism to prevent tissue damage. Our results suggest that the rise in PAI-1 in type II diabetics with complications may be a good marker of vascular endothelial dysfunction.

Antioxidant status and lipid peroxidation in type II diabetes mellitus

2003 ◽  
Vol 21 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Ramazan Mem?so?ullari ◽  
Seyithan Tays? ◽  
Ebubekir Bakan ◽  
Ilyas Capoglu
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Type Ii Diabetes ◽  
Antioxidant Status ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

Antioxidant status of Mauritian subjects with type II diabetes mellitus

2013 ◽  
Vol 33 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Vidushi Shradha Neergheen-Bhujun ◽  
Halimah Rosun ◽  
Noorjehan Joonas ◽  
Theeshan Bahorun
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Antioxidant Status ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii
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