scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multigenerational, Prospective Analysis in the Framingham Heart Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (12) ◽  
pp. 3086-3093
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Prospective Analysis ◽  
Heart Study

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study

2020 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Second Generation ◽  
Cardiovascular Death ◽  
Diabetes Risk ◽  
Coronary Death ◽  
Onset Diabetes ◽  
Heart Study

<b>Objective:</b> To assess the influence of type 2 diabetes occurring earlier (age <55 years) versus later in life, on the risk of cardiovascular death, and of diabetes in offspring. <p><b>Research Design and Methods: </b>In the Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5571 first- and second-generation participants with mortality data; and 2123 initially non-diabetic second-generation participants with data on parental diabetes status. We assessed cause of death in a case (cardiovascular death) - control (non-cardiovascular death) design, and incident diabetes in offspring in relation to parental early-onset diabetes. </p> <p><b>Results:</b> Of the participants in two generations (N=5571), there were 1822 cardiovascular deaths (including 961 coronary deaths). The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). Compared with persons who never developed diabetes, early-onset diabetes conferred a 1.81-fold odds (95% confidence interval [CI] 1.10-2.97, <i>P=</i>0.02) of cardiovascular death and 1.75-fold (0.96-3.21,<i> P=</i>0.07) odds of coronary death, whereas later-onset diabetes was not associated with greater risk for either (<i>P</i>=0.09 for cardiovascular death; <i>P=</i>0.51 for coronary death). In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).</p> <b>Conclusions</b>: Our findings provide evidence for a diabetes subgroup with an early onset, a stronger association with cardiovascular death, and higher transgenerational transmission.

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study

2020 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Second Generation ◽  
Cardiovascular Death ◽  
Diabetes Risk ◽  
Coronary Death ◽  
Onset Diabetes ◽  
Heart Study

<b>Objective:</b> To assess the influence of type 2 diabetes occurring earlier (age <55 years) versus later in life, on the risk of cardiovascular death, and of diabetes in offspring. <p><b>Research Design and Methods: </b>In the Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5571 first- and second-generation participants with mortality data; and 2123 initially non-diabetic second-generation participants with data on parental diabetes status. We assessed cause of death in a case (cardiovascular death) - control (non-cardiovascular death) design, and incident diabetes in offspring in relation to parental early-onset diabetes. </p> <p><b>Results:</b> Of the participants in two generations (N=5571), there were 1822 cardiovascular deaths (including 961 coronary deaths). The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). Compared with persons who never developed diabetes, early-onset diabetes conferred a 1.81-fold odds (95% confidence interval [CI] 1.10-2.97, <i>P=</i>0.02) of cardiovascular death and 1.75-fold (0.96-3.21,<i> P=</i>0.07) odds of coronary death, whereas later-onset diabetes was not associated with greater risk for either (<i>P</i>=0.09 for cardiovascular death; <i>P=</i>0.51 for coronary death). In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).</p> <b>Conclusions</b>: Our findings provide evidence for a diabetes subgroup with an early onset, a stronger association with cardiovascular death, and higher transgenerational transmission.

A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1715-P
Author(s):  
SHYLAJA SRINIVASAN ◽  
AARON LEONG ◽  
MIRIAM UDLER ◽  
BIANCA C. PORNEALA ◽  
JAMES B. MEIGS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Framingham Heart Study ◽  
Genetic Risk Score ◽  
Heart Study

Early-Onset Subgroup of Type 2 Diabetes and Risk of Dementia, Alzheimer’s disease and Stroke: A Cohort Study

2021 ◽  
pp. 1-6
Author(s):  
K. Wang ◽  
H. Liu
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Glycemic Status ◽  
Community Based ◽  
Diabetes Onset ◽  
Onset Diabetes ◽  
Heart Study ◽  
Increased Risk ◽  
Onset Of Diabetes

BACKGROUND: This study aimed to assess the relation of early-onset type 2 diabetes (age<55years) versus later in life to the risk of dementia, Alzheimer Disease (AD) dementia and stroke. Methods: This study was based on the Framingham Heart Study Offspring cohort (FHS-OS) which is a community-based prospective cohort. Glycemic status was ascertained at serial examinations over six decades among participants who initially did not have diabetes. Surveillance for incident events including dementia and stroke has been continued for approximately 30 years. Results: At baseline, there were 142 (5%) subjects with onset of diabetes prior to age 55 years, 172 (6%) subjects with 55-64 years, 349 (11%) subjects over 65 years and 2389 (78%) subjects without diabetes. The risk of dementia, AD and stroke increased with decreasing age of diabetes onset (P<0.05, for trend). Compared with never developing diabetes, early-onset diabetes conferred a higher risk of all dementia, AD dementia and stroke [HR 2.86(1.16-5.51) for dementia; HR 2.42(1.63-4.33) for AD; HR 2.85(1.37-3.98) for stroke]. Whereas later-onset diabetes was only associated with greater risk for stroke, neither dementia nor AD. Conclusion: Early-onset diabetes was stronger associated with an increased risk of all dementia, AD dementia and stroke than later-onset.

Polymorphisms in the Insulin-Degrading Enzyme Gene Are Associated With Type 2 Diabetes in Men From the NHLBI Framingham Heart Study

Diabetes ◽  
2003 ◽  
Vol 52 (6) ◽  
pp. 1562-1567 ◽  
Author(s):  
S. Karamohamed ◽  
S. Demissie ◽  
J. Volcjak ◽  
C. Liu ◽  
N. Heard-Costa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Framingham Heart Study ◽  
Insulin Degrading Enzyme ◽  
Enzyme Gene ◽  
Degrading Enzyme ◽  
Heart Study

scholarly journals Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study

BMJ ◽  
2017 ◽  
pp. j1949 ◽  
Author(s):  
Teemu J Niiranen ◽  
Elizabeth L McCabe ◽  
Martin G Larson ◽  
Mir Henglin ◽  
Neal K Lakdawala ◽  
...  
Keyword(s):  
Early Onset ◽  
Framingham Heart Study ◽  
Prospective Analysis ◽  
Heart Study

scholarly journals Risk Factors for Incident Fracture in Older Adults With Type 2 Diabetes: The Framingham Heart Study

Diabetes Care ◽  
2021 ◽  
pp. dc203150
Author(s):  
Alyssa B. Dufour ◽  
Douglas P. Kiel ◽  
Setareh A. Williams ◽  
Richard J. Weiss ◽  
Elizabeth J. Samelson
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Framingham Heart Study ◽  
Incident Fracture ◽  
Heart Study
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