scholarly journals Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study

BMJ ◽  
2017 ◽  
pp. j1949 ◽  
Author(s):  
Teemu J Niiranen ◽  
Elizabeth L McCabe ◽  
Martin G Larson ◽  
Mir Henglin ◽  
Neal K Lakdawala ◽  
...  
Keyword(s):  
Early Onset ◽  
Framingham Heart Study ◽  
Prospective Analysis ◽  
Heart Study

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multigenerational, Prospective Analysis in the Framingham Heart Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (12) ◽  
pp. 3086-3093
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Prospective Analysis ◽  
Heart Study

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study

2020 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Second Generation ◽  
Cardiovascular Death ◽  
Diabetes Risk ◽  
Coronary Death ◽  
Onset Diabetes ◽  
Heart Study

<b>Objective:</b> To assess the influence of type 2 diabetes occurring earlier (age <55 years) versus later in life, on the risk of cardiovascular death, and of diabetes in offspring. <p><b>Research Design and Methods: </b>In the Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5571 first- and second-generation participants with mortality data; and 2123 initially non-diabetic second-generation participants with data on parental diabetes status. We assessed cause of death in a case (cardiovascular death) - control (non-cardiovascular death) design, and incident diabetes in offspring in relation to parental early-onset diabetes. </p> <p><b>Results:</b> Of the participants in two generations (N=5571), there were 1822 cardiovascular deaths (including 961 coronary deaths). The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). Compared with persons who never developed diabetes, early-onset diabetes conferred a 1.81-fold odds (95% confidence interval [CI] 1.10-2.97, <i>P=</i>0.02) of cardiovascular death and 1.75-fold (0.96-3.21,<i> P=</i>0.07) odds of coronary death, whereas later-onset diabetes was not associated with greater risk for either (<i>P</i>=0.09 for cardiovascular death; <i>P=</i>0.51 for coronary death). In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).</p> <b>Conclusions</b>: Our findings provide evidence for a diabetes subgroup with an early onset, a stronger association with cardiovascular death, and higher transgenerational transmission.

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study

2020 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Second Generation ◽  
Cardiovascular Death ◽  
Diabetes Risk ◽  
Coronary Death ◽  
Onset Diabetes ◽  
Heart Study

<b>Objective:</b> To assess the influence of type 2 diabetes occurring earlier (age <55 years) versus later in life, on the risk of cardiovascular death, and of diabetes in offspring. <p><b>Research Design and Methods: </b>In the Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5571 first- and second-generation participants with mortality data; and 2123 initially non-diabetic second-generation participants with data on parental diabetes status. We assessed cause of death in a case (cardiovascular death) - control (non-cardiovascular death) design, and incident diabetes in offspring in relation to parental early-onset diabetes. </p> <p><b>Results:</b> Of the participants in two generations (N=5571), there were 1822 cardiovascular deaths (including 961 coronary deaths). The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). Compared with persons who never developed diabetes, early-onset diabetes conferred a 1.81-fold odds (95% confidence interval [CI] 1.10-2.97, <i>P=</i>0.02) of cardiovascular death and 1.75-fold (0.96-3.21,<i> P=</i>0.07) odds of coronary death, whereas later-onset diabetes was not associated with greater risk for either (<i>P</i>=0.09 for cardiovascular death; <i>P=</i>0.51 for coronary death). In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).</p> <b>Conclusions</b>: Our findings provide evidence for a diabetes subgroup with an early onset, a stronger association with cardiovascular death, and higher transgenerational transmission.

scholarly journals Thresholds for Abdominal Aortic Calcium That Predict Cardiovascular Disease Events in the Framingham Heart Study

2020 ◽  
Author(s):  
Sumbal A. Janjua ◽  
Joseph M. Massaro ◽  
Michael L. Chuang ◽  
Ralph B. D’Agostino ◽  
Udo Hoffmann ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Framingham Heart Study ◽  
Abdominal Aortic ◽  
Heart Study

scholarly journals Relations of liver fat with prevalent and incident chronic kidney disease in the Framingham Heart Study: A secondary analysis

2019 ◽  
Vol 39 (8) ◽  
pp. 1535-1544 ◽  
Author(s):  
Robert M. Wilechansky ◽  
Alison Pedley ◽  
Joseph M. Massaro ◽  
Udo Hoffmann ◽  
Emelia J. Benjamin ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Framingham Heart Study ◽  
Secondary Analysis ◽  
Liver Fat ◽  
Heart Study ◽  
Incident Chronic Kidney Disease
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