scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study

2020 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Second Generation ◽  
Cardiovascular Death ◽  
Diabetes Risk ◽  
Coronary Death ◽  
Onset Diabetes ◽  
Heart Study

<b>Objective:</b> To assess the influence of type 2 diabetes occurring earlier (age <55 years) versus later in life, on the risk of cardiovascular death, and of diabetes in offspring. <p><b>Research Design and Methods: </b>In the Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5571 first- and second-generation participants with mortality data; and 2123 initially non-diabetic second-generation participants with data on parental diabetes status. We assessed cause of death in a case (cardiovascular death) - control (non-cardiovascular death) design, and incident diabetes in offspring in relation to parental early-onset diabetes. </p> <p><b>Results:</b> Of the participants in two generations (N=5571), there were 1822 cardiovascular deaths (including 961 coronary deaths). The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). Compared with persons who never developed diabetes, early-onset diabetes conferred a 1.81-fold odds (95% confidence interval [CI] 1.10-2.97, <i>P=</i>0.02) of cardiovascular death and 1.75-fold (0.96-3.21,<i> P=</i>0.07) odds of coronary death, whereas later-onset diabetes was not associated with greater risk for either (<i>P</i>=0.09 for cardiovascular death; <i>P=</i>0.51 for coronary death). In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).</p> <b>Conclusions</b>: Our findings provide evidence for a diabetes subgroup with an early onset, a stronger association with cardiovascular death, and higher transgenerational transmission.

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study

2020 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Second Generation ◽  
Cardiovascular Death ◽  
Diabetes Risk ◽  
Coronary Death ◽  
Onset Diabetes ◽  
Heart Study

<b>Objective:</b> To assess the influence of type 2 diabetes occurring earlier (age <55 years) versus later in life, on the risk of cardiovascular death, and of diabetes in offspring. <p><b>Research Design and Methods: </b>In the Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5571 first- and second-generation participants with mortality data; and 2123 initially non-diabetic second-generation participants with data on parental diabetes status. We assessed cause of death in a case (cardiovascular death) - control (non-cardiovascular death) design, and incident diabetes in offspring in relation to parental early-onset diabetes. </p> <p><b>Results:</b> Of the participants in two generations (N=5571), there were 1822 cardiovascular deaths (including 961 coronary deaths). The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). Compared with persons who never developed diabetes, early-onset diabetes conferred a 1.81-fold odds (95% confidence interval [CI] 1.10-2.97, <i>P=</i>0.02) of cardiovascular death and 1.75-fold (0.96-3.21,<i> P=</i>0.07) odds of coronary death, whereas later-onset diabetes was not associated with greater risk for either (<i>P</i>=0.09 for cardiovascular death; <i>P=</i>0.51 for coronary death). In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).</p> <b>Conclusions</b>: Our findings provide evidence for a diabetes subgroup with an early onset, a stronger association with cardiovascular death, and higher transgenerational transmission.

Early-Onset Subgroup of Type 2 Diabetes and Risk of Dementia, Alzheimer’s disease and Stroke: A Cohort Study

2021 ◽  
pp. 1-6
Author(s):  
K. Wang ◽  
H. Liu
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Glycemic Status ◽  
Community Based ◽  
Diabetes Onset ◽  
Onset Diabetes ◽  
Heart Study ◽  
Increased Risk ◽  
Onset Of Diabetes

BACKGROUND: This study aimed to assess the relation of early-onset type 2 diabetes (age<55years) versus later in life to the risk of dementia, Alzheimer Disease (AD) dementia and stroke. Methods: This study was based on the Framingham Heart Study Offspring cohort (FHS-OS) which is a community-based prospective cohort. Glycemic status was ascertained at serial examinations over six decades among participants who initially did not have diabetes. Surveillance for incident events including dementia and stroke has been continued for approximately 30 years. Results: At baseline, there were 142 (5%) subjects with onset of diabetes prior to age 55 years, 172 (6%) subjects with 55-64 years, 349 (11%) subjects over 65 years and 2389 (78%) subjects without diabetes. The risk of dementia, AD and stroke increased with decreasing age of diabetes onset (P<0.05, for trend). Compared with never developing diabetes, early-onset diabetes conferred a higher risk of all dementia, AD dementia and stroke [HR 2.86(1.16-5.51) for dementia; HR 2.42(1.63-4.33) for AD; HR 2.85(1.37-3.98) for stroke]. Whereas later-onset diabetes was only associated with greater risk for stroke, neither dementia nor AD. Conclusion: Early-onset diabetes was stronger associated with an increased risk of all dementia, AD dementia and stroke than later-onset.

scholarly journals An Early-Onset Subgroup of Type 2 Diabetes: A Multigenerational, Prospective Analysis in the Framingham Heart Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (12) ◽  
pp. 3086-3093
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Teemu J. Niiranen ◽  
Elizabeth L. McCabe ◽  
Mir Henglin ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Framingham Heart Study ◽  
Prospective Analysis ◽  
Heart Study

scholarly journals Metabolic factors and genetic risk mediate familial type 2 diabetes risk in the Framingham Heart Study

Diabetologia ◽  
2015 ◽  
Vol 58 (5) ◽  
pp. 988-996 ◽  
Author(s):  
Sridharan Raghavan ◽  
Bianca Porneala ◽  
Nicola McKeown ◽  
Caroline S. Fox ◽  
Josée Dupuis ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Risk ◽  
Framingham Heart Study ◽  
Diabetes Risk ◽  
Metabolic Factors ◽  
Heart Study ◽  
Familial Type

Molecular and phenotypic characteristics of maturity-onset diabetes of the young compared with early onset type 2 diabetes in China

2015 ◽  
Vol 7 (6) ◽  
pp. 858-863 ◽  
Author(s):  
Manna Zhang ◽  
Jiao Jiao Zhou ◽  
Wenjie Cui ◽  
Yan Li ◽  
Peng Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Maturity Onset Diabetes ◽  
Phenotypic Characteristics ◽  
Onset Type ◽  
Onset Diabetes

A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1715-P
Author(s):  
SHYLAJA SRINIVASAN ◽  
AARON LEONG ◽  
MIRIAM UDLER ◽  
BIANCA C. PORNEALA ◽  
JAMES B. MEIGS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Framingham Heart Study ◽  
Genetic Risk Score ◽  
Heart Study

Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus

2009 ◽  
Vol 70 (6) ◽  
pp. 847-853 ◽  
Author(s):  
Nattachet Plengvidhya ◽  
Watip Boonyasrisawat ◽  
Nalinee Chongjaroen ◽  
Prapaporn Jungtrakoon ◽  
Sutin Sriussadaporn ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Early Onset ◽  
Maturity Onset Diabetes ◽  
Onset Type ◽  
Onset Diabetes

scholarly journals Identification of HNF4A Mutation p.T130I and HNF1A Mutations p.I27L and p.S487N in a Han Chinese Family with Early-Onset Maternally Inherited Type 2 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Yang ◽  
Tai-Cheng Zhou ◽  
Yong-Ying Liu ◽  
Xiao Li ◽  
Wen-Xue Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Late Onset ◽  
Positive Family History ◽  
Dominant Mode ◽  
Han Chinese ◽  
Chinese Family ◽  
Onset Diabetes ◽  
Age Of Diagnosis

Maturity-onset diabetes of the young (MODY) is characterized by the onset of diabetes before the age of 25 years, positive family history, high genetic predisposition, monogenic mutations, and an autosomal dominant mode of inheritance. Here, we aimed to investigate the mutations and to characterize the phenotypes of a Han Chinese family with early-onset maternally inherited type 2 diabetes. Detailed clinical assessments and genetic screening for mutations in theHNF4α,GCK,HNF-1α,IPF-1,HNF1β, andNEUROD1genes were carried out in this family. One HNF4A mutation (p.T130I) and two HNF1A polymorphisms (p.I27L and p.S487N) were identified. Mutation p.T130I was associated with both early-onset and late-onset diabetes and caused downregulatedHNF4Aexpression, whereas HNF1A polymorphisms p.I27L and p.S487N were associated with the age of diagnosis of diabetes. We demonstrated that mutation p.T130I in HNF4A was pathogenic as were the predicted polymorphisms p.I27L and p.S487N in HNF1A by genetic and functional analysis. Our results show that mutations inHNF4AandHNF1Agenes might account for this early-onset inherited type 2 diabetes.

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