scholarly journals Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy

Diabetes Care ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 656-661 ◽  
Author(s):  
S. S. Kim ◽  
S. H. Song ◽  
I. J. Kim ◽  
Y. K. Jeon ◽  
B. H. Kim ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Tubular Proteinuria ◽  
Urinary Cystatin C

scholarly journals Assessment of Cystatin C and Microalbumin as Biomarkers for Nephropathy in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 10 (25) ◽  
pp. 1866-1870
Author(s):  
Bhuneshwar Yadav ◽  
Shashidhar K.N ◽  
Raveesha A ◽  
Muninarayana C.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Elevated Serum ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin

BACKGROUND Increased levels of urinary biomarkers can be detected in type 2 diabetic patients before the onset of significant albuminuria and may be used as an early marker of renal injury in diabetic nephropathy (DN) which would play a significant role for the effective management and treatment approaches in diabetic care. We wanted to evaluate cystatin C and microalbumin as effective early biomarkers in assessing nephropathy in patients with type 2 diabetes mellitus in this study. METHODS A cross-sectional study was conducted among 180 subjects grouped into healthy controls, clinically proven T2DM without nephropathy and type 2 DM with nephropathy comprising 60 participants in each group. Fasting and postprandial blood samples and urine samples were collected and analysed by standard methods. eGFR was calculated using CKD-EPI 2012 equation. IBM - SPSS version 20 was used for statistical analysis. RESULTS Diabetic nephropathy patients had significantly elevated serum cystatin C and microalbumin (2.43 ± 0.59, 700.5 ± 591.8 mg / L, respectively), compared to T2DM (0.98 ± 0.26, 63.7 ± 102.9 mg / L, respectively), and the control study subjects (0.81 ± 0.16, 11.15 ± 8.9 mg / L, respectively). Serum cystatin C showed AUC of 0.994 (95 % CI, 0.986 - 1.00) whereas microalbumin showed 0.944 (95 % CI, 0.907 - 0.981). Serum cystatin C showed a sensitivity of 96.7 % and a specificity of 91.7 % at a cutoff point of 1.34 mg / L whereas at a cut-off point of 138.5 mg / L for microalbumin, the sensitivity and specificity were 90 % and 83.3 % respectively. CONCLUSIONS Serum cystatin C and microalbumin both could be considered as markers for early detection of nephropathy in T2DM patients. The more prominent rise in serum cystatin C values provide an earlier diagnosis of diabetic nephropathy among T2DM patients. KEY WORDS Biomarker, Type 2 Diabetes Mellitus, Cystatin C, Diabetic Nephropathy, Microalbumin

scholarly journals Assessment of urinary cystatin C levels in HIV-1-infected patients with preserved kidney function

2018 ◽  
Vol 17 (4) ◽  
pp. 236-242
Author(s):  
Aleksandra Szymczak ◽  
Anna Szymanek-Pasternak ◽  
Małgorzata Zalewska ◽  
Krzysztof Małyszczak ◽  
Weronika Rymer ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Urinary Cystatin C ◽  
Hiv 1

A Simple Method to Evaluate Residual Renal Function by Spot Urinary Cystatin C-to-Creatinine Ratio in Peritoneal Dialysis Patients

2010 ◽  
Vol 30 (4) ◽  
pp. 464-467 ◽  
Author(s):  
Yoko Adachi ◽  
Akira Nishio
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Cystatin C ◽  
Screening Method ◽  
Residual Renal Function ◽  
Urine Collection ◽  
Creatinine Ratio ◽  
Simple Method ◽  
Spot Urine ◽  
Urinary Cystatin C

Residual renal function (RRF) is a key element in the management of chronic peritoneal dialysis (PD) patients, and 24-hour creatinine clearance (24-h Ccr) and arithmetic mean of creatinine and urea nitrogen clearances [24-h (Ccr+Curea)/2] are still standard clinical techniques for the assessment of glomerular filtration rate (GFR) to represent RRF. However, it is sometimes difficult to monitor urine collection for 24 hours, especially in outpatients, and it requires serum sampling. Therefore, we devised a new and simple method to measure RRF in prevalent PD patients. Levels of urinary cystatin C (Cys-C) and creatinine in spot urine samples [24-h (Ccr+Curea)/2] were measured in 15 stable Japanese PD patients. Although no statistical correlation was seen between Cys-C and 24-h (Ccr+Curea)/2 values, a strong correlation was found between the spot urine Cys-C-to-creatinine ratio [U (Cys-C/Cr)] and 24-h (Ccr+Curea)/2. By simple linear regression analysis, the following regression equation was derived: y = 17.0 – 6.1x, where x = log 10000*U (Cys-C/Cr) ratio and y = 24-h (Ccr+Curea)/2. Measurement of U (Cys-C/Cr) ratio does not require serum sampling or 24-hour urine collection but requires only a spot urine sample. We suggest that the U (Cys-C/Cr) ratio is a simple and easy screening method to estimate GFR in PD patients.

Urinary cystatin C as a specific marker of tubular dysfunction

2006 ◽  
Vol 44 (3) ◽  
Author(s):  
Marc Conti ◽  
Stéphane Moutereau ◽  
Mokhtar Zater ◽  
Karim Lallali ◽  
Antoine Durrbach ◽  
...  
Keyword(s):  
Cystatin C ◽  
Specific Marker ◽  
Tubular Dysfunction ◽  
Urinary Cystatin C

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