Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats

2013 ◽  
Vol 65 (5) ◽  
pp. 615-622 ◽  
Author(s):  
Yuko Togashi ◽  
Yohei Miyamoto
Keyword(s):  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Immunohistochemical Localization ◽  
Zdf Rats ◽  
Urinary Cystatin C

scholarly journals Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy

Diabetes Care ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 656-661 ◽  
Author(s):  
S. S. Kim ◽  
S. H. Song ◽  
I. J. Kim ◽  
Y. K. Jeon ◽  
B. H. Kim ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Tubular Proteinuria ◽  
Urinary Cystatin C

scholarly journals Assessment of Cystatin C and Microalbumin as Biomarkers for Nephropathy in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 10 (25) ◽  
pp. 1866-1870
Author(s):  
Bhuneshwar Yadav ◽  
Shashidhar K.N ◽  
Raveesha A ◽  
Muninarayana C.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Elevated Serum ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin

BACKGROUND Increased levels of urinary biomarkers can be detected in type 2 diabetic patients before the onset of significant albuminuria and may be used as an early marker of renal injury in diabetic nephropathy (DN) which would play a significant role for the effective management and treatment approaches in diabetic care. We wanted to evaluate cystatin C and microalbumin as effective early biomarkers in assessing nephropathy in patients with type 2 diabetes mellitus in this study. METHODS A cross-sectional study was conducted among 180 subjects grouped into healthy controls, clinically proven T2DM without nephropathy and type 2 DM with nephropathy comprising 60 participants in each group. Fasting and postprandial blood samples and urine samples were collected and analysed by standard methods. eGFR was calculated using CKD-EPI 2012 equation. IBM - SPSS version 20 was used for statistical analysis. RESULTS Diabetic nephropathy patients had significantly elevated serum cystatin C and microalbumin (2.43 ± 0.59, 700.5 ± 591.8 mg / L, respectively), compared to T2DM (0.98 ± 0.26, 63.7 ± 102.9 mg / L, respectively), and the control study subjects (0.81 ± 0.16, 11.15 ± 8.9 mg / L, respectively). Serum cystatin C showed AUC of 0.994 (95 % CI, 0.986 - 1.00) whereas microalbumin showed 0.944 (95 % CI, 0.907 - 0.981). Serum cystatin C showed a sensitivity of 96.7 % and a specificity of 91.7 % at a cutoff point of 1.34 mg / L whereas at a cut-off point of 138.5 mg / L for microalbumin, the sensitivity and specificity were 90 % and 83.3 % respectively. CONCLUSIONS Serum cystatin C and microalbumin both could be considered as markers for early detection of nephropathy in T2DM patients. The more prominent rise in serum cystatin C values provide an earlier diagnosis of diabetic nephropathy among T2DM patients. KEY WORDS Biomarker, Type 2 Diabetes Mellitus, Cystatin C, Diabetic Nephropathy, Microalbumin

scholarly journals Assessment of urinary cystatin C levels in HIV-1-infected patients with preserved kidney function

2018 ◽  
Vol 17 (4) ◽  
pp. 236-242
Author(s):  
Aleksandra Szymczak ◽  
Anna Szymanek-Pasternak ◽  
Małgorzata Zalewska ◽  
Krzysztof Małyszczak ◽  
Weronika Rymer ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Urinary Cystatin C ◽  
Hiv 1
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