483-P: Key Biochemical and Histopathological Markers of Diabetic Nephropathy Correlate with Hypertension in the Renin-AAV Uninephrectomized db/db Mouse Model

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 483-P
Author(s):  
METTE V. ØSTERGAARD ◽  
IDA R. SØRENSEN ◽  
ANNEMARIE A. PEDERSEN ◽  
THOMAS SECHER ◽  
FREDERIKKE E. SEMBACH ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model

Diabetic kidney disease in thedb/dbmouse

2003 ◽  
Vol 284 (6) ◽  
pp. F1138-F1144 ◽  
Author(s):  
Kumar Sharma ◽  
Peter McCue ◽  
Stephen R. Dunn
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Mouse Model ◽  
Renal Disease ◽  
Mouse Models ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Matrix Expansion ◽  
Stage Renal Disease ◽  
End Stage

Diabetic nephropathy is increasing in incidence and is now the number one cause of end-stage renal disease in the industrialized world. To gain insight into the genetic susceptibility and pathophysiology of diabetic nephropathy, an appropriate mouse model of diabetic nephropathy would be critical. A large number of mouse models of diabetes have been identified and their kidney disease characterized to various degrees. Perhaps the best characterized and most intensively investigated model is the db/ db mouse. Because this model appears to exhibit the most consistent and robust increase in albuminuria and mesangial matrix expansion, it has been used as a model of progressive diabetic renal disease. In this review, we present the findings from various studies on the renal pathology of the db/ db mouse model of diabetes in the context of human diabetic nephropathy. Furthermore, we discuss shortfalls of assessing functional renal disease in mouse models of diabetic kidney disease.

Pathogenesis and Treatment of Type 2 Diabetic Nephropathy: Lessons from the Spontaneous KK/Ta Mouse Model

2005 ◽  
Vol 1 (3) ◽  
pp. 281-286 ◽  
Author(s):  
Yasuhiko Tomino ◽  
Mitsuo Tanimoto ◽  
Toshihide Shike ◽  
Kenji Shiina ◽  
Qiuling Fan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Type 2 Diabetic

Softened food reduces weight loss in the streptozotocin-induced male mouse model of diabetic nephropathy

2018 ◽  
Vol 52 (4) ◽  
pp. 373-383 ◽  
Author(s):  
Sisse A Nørgaard ◽  
Fredrik W Sand ◽  
Dorte B Sørensen ◽  
Klas SP Abelson ◽  
Henrik Søndergaard
Keyword(s):  
Weight Loss ◽  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Diabetic Mouse ◽  
Diabetic Mice ◽  
Reduce Weight Loss ◽  
Normal Chow ◽  
Corticosterone Metabolites ◽  
Reducing Stress ◽  
Humane Endpoint

The streptozotocin (STZ)-induced diabetic mouse is a widely used model of diabetes and diabetic nephropathy (DN). However, it is a well-known issue that this model is challenged by high weight loss, which despite supportive measures often results in high euthanization rates. To overcome these issues, we hypothesized that supplementing STZ-induced diabetic mice with water-softened chow in addition to normal chow would reduce weight loss, lower the need for supportive treatment, and reduce the number of mice reaching the humane endpoint of 20% weight loss. In a 15 week STZ-induced DN study we demonstrated that diabetic male mice receiving softened chow had reduced acute weight loss following STZ treatment ( p = 0.045) and additionally fewer mice were euthanized due to weight loss. By supplementing the diabetic mice with softened chow, no mice reached 20% weight loss whereas 37.5% of the mice without this supplement reached this humane endpoint ( p = 0.0027). Excretion of corticosterone metabolites in faeces was reduced in diabetic mice on softened chow ( p = 0.0007), suggesting lower levels of general stress. Finally, it was demonstrated that the water-softened chow supplement did not significantly affect the induction of key disease parameters, i.e. %HbA1C and albuminuria nor result in abnormal teeth wear. In conclusion, supplementation of softened food is refining the STZ-induced diabetic mouse model significantly by reducing stress, weight loss and the number of animals sacrificed due to humane endpoints, while maintaining the key phenotypes of diabetes and nephropathy.

scholarly journals Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy

Diabetes ◽  
2009 ◽  
Vol 58 (10) ◽  
pp. 2365-2375 ◽  
Author(s):  
T. Nasu ◽  
Y. Maeshima ◽  
M. Kinomura ◽  
K. Hirokoshi-Kawahara ◽  
K. Tanabe ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Negative Feedback ◽  
Feedback Regulator

scholarly journals Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy

Diabetes ◽  
2011 ◽  
Vol 60 (9) ◽  
pp. 2386-2396 ◽  
Author(s):  
F. Barutta ◽  
F. Piscitelli ◽  
S. Pinach ◽  
G. Bruno ◽  
R. Gambino ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Cannabinoid Receptor ◽  
Protective Role ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2

scholarly journals The effects of dual PPARα /γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy

2017 ◽  
Vol 5 (5) ◽  
pp. e13186 ◽  
Author(s):  
Anette Ericsson ◽  
Pernilla Tonelius ◽  
Mark Lal ◽  
Alan Sabirsh ◽  
Gerhard Böttcher ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Ace Inhibition

Low‐Dose Metformin Treatment Ameliorates Renal Dysfunction and Fibrosis in a Mouse Model of Diabetic Nephropathy

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Shankar Munusamy ◽  
Christopher Karch ◽  
Ronald Frantz ◽  
Kevin Carnevale
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Renal Dysfunction ◽  
Low Dose ◽  
Metformin Treatment
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